4,5-dihydroxypyrimidine carboxamides and N-alkyl-5-hydroxypyrimidinone carboxamides are potent, selective HIV integrase inhibitors with good pharmacokinetic profiles in preclinical species.
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M. Rowley | V. Summa | A. Petrocchi | V. Matassa | R. Laufer | P. Pace | E. Muraglia | Cristina Gardelli | O. G. Paz | E. Monteagudo