ACSL4 promotes microglia-mediated neuroinflammation by regulating lipid metabolism and VGLL4 expression

[1]  C. Trautwein,et al.  ACSL4-dependent ferroptosis does not represent a tumor-suppressive mechanism but ACSL4 rather promotes liver cancer progression , 2022, Cell Death & Disease.

[2]  Jian-ning Zhang,et al.  Endoplasmic Reticulum Stress-Associated Neuronal Death and Innate Immune Response in Neurological Diseases , 2022, Frontiers in Immunology.

[3]  E. Wohleb,et al.  The semantics of microglia activation: neuroinflammation, homeostasis, and stress , 2021, Journal of Neuroinflammation.

[4]  Xianlin Han,et al.  Myeloid-Specific Deficiency of Long-Chain Acyl CoA Synthetase 4 Reduces Inflammation by Remodeling Phospholipids and Reducing Production of Arachidonic Acid-Derived Proinflammatory Lipid Mediators. , 2021, Journal of immunology.

[5]  Yongyu Wang,et al.  Upregulation of KDM6B contributes to lipopolysaccharide-induced anxiety-like behavior via modulation of VGLL4 in mice , 2021, Behavioural Brain Research.

[6]  Yuanchen Cui,et al.  ACSL4 exacerbates ischemic stroke by promoting ferroptosis-induced brain injury and neuroinflammation , 2021, Brain, Behavior, and Immunity.

[7]  Haiyang Xie,et al.  ACSL4 reprograms fatty acid metabolism in hepatocellular carcinoma via c-Myc/SREBP1 pathway. , 2020, Cancer letters.

[8]  S. Koh,et al.  Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes , 2020, Translational Neurodegeneration.

[9]  M. Kornberg,et al.  The Role of Metabolic Enzymes in the Regulation of Inflammation , 2020, Metabolites.

[10]  Rohit Reja,et al.  Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPβ in Microglia , 2020, Cell.

[11]  N. Yamaguchi.  Multiple Roles of Vestigial-Like Family Members in Tumor Development , 2020, Frontiers in Oncology.

[12]  C. Limatola,et al.  Metabolic Reprograming of Microglia in the Regulation of the Innate Inflammatory Response , 2020, Frontiers in Immunology.

[13]  John H. Zhang,et al.  Glial Cells: Role of the Immune Response in Ischemic Stroke , 2020, Frontiers in Immunology.

[14]  M. Shibanuma,et al.  Long-chain acyl-CoA synthetase 4 participates in the formation of highly unsaturated fatty acid-containing phospholipids in murine macrophages. , 2019, Biochimica et biophysica acta. Molecular and cell biology of lipids.

[15]  Jinhui Li,et al.  Dual function of VGLL4 in muscle regeneration , 2019, The EMBO journal.

[16]  Ying Sun,et al.  NG2 glia regulate brain innate immunity via TGF-β2/TGFBR2 axis , 2019, BMC Medicine.

[17]  B. Joseph,et al.  TET2 regulates the neuroinflammatory response in microglia , 2019, bioRxiv.

[18]  S. Duan,et al.  CD73-derived adenosine controls inflammation and neurodegeneration by modulating dopamine signalling , 2019, Brain : a journal of neurology.

[19]  H. Ji,et al.  VGLL4 plays a critical role in heart valve development and homeostasis , 2019, PLoS genetics.

[20]  D. Choi,et al.  Cellular phenotypes as inflammatory mediators in Parkinson's disease: Interventional targets and role of natural products. , 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[21]  Thijs J. Hagenbeek,et al.  The Hippo pathway effector TAZ induces TEAD-dependent liver inflammation and tumors , 2018, Science Signaling.

[22]  Yongyi Ye,et al.  A lincRNA-p21/miR-181 family feedback loop regulates microglial activation during systemic LPS- and MPTP- induced neuroinflammation , 2018, Cell Death & Disease.

[23]  Lin Fang,et al.  VGLL4 is a transcriptional cofactor acting as a novel tumor suppressor via interacting with TEADs. , 2018, American journal of cancer research.

[24]  D. Gibson,et al.  Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines , 2018, Front. Immunol..

[25]  L. Sevenich.  Brain-Resident Microglia and Blood-Borne Macrophages Orchestrate Central Nervous System Inflammation in Neurodegenerative Disorders and Brain Cancer , 2018, Front. Immunol..

[26]  L. Du,et al.  Role of Microglia in Neurological Disorders and Their Potentials as a Therapeutic Target , 2017, Molecular Neurobiology.

[27]  Mikko T. Huuskonen,et al.  DHCR24 exerts neuroprotection upon inflammation-induced neuronal death , 2017, Journal of Neuroinflammation.

[28]  Zhaocai Zhou,et al.  VGLL4 targets a TCF4–TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer , 2017, Nature Communications.

[29]  Souvarish Sarkar,et al.  Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease , 2016, Neurobiology of Disease.

[30]  G. Katona,et al.  Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke , 2016, Nature Communications.

[31]  P. Carmeliet,et al.  Deletion or Inhibition of the Oxygen Sensor PHD1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism. , 2016, Cell metabolism.

[32]  G. Pavesi,et al.  miR-17-92 fine-tunes MYC expression and function to ensure optimal B cell lymphoma growth , 2015, Nature Communications.

[33]  N. Færgeman,et al.  Long-chain acyl-CoA esters in metabolism and signaling: Role of acyl-CoA binding proteins. , 2015, Progress in lipid research.

[34]  Vellareddy Anantharam,et al.  Fyn Kinase Regulates Microglial Neuroinflammatory Responses in Cell Culture and Animal Models of Parkinson's Disease , 2014, The Journal of Neuroscience.

[35]  W. Le,et al.  Jmjd3 is essential for the epigenetic modulation of microglia phenotypes in the immune pathogenesis of Parkinson’s disease , 2013, Cell Death and Differentiation.

[36]  W. Shao,et al.  Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αB-crystallin , 2012, Nature.

[37]  Joshua A. Smith,et al.  Neuroprotective effects of genistein in VSC4.1 motoneurons exposed to activated microglial cytokines , 2011, Neurochemistry International.

[38]  S. Sakoda,et al.  SIK2 Is a Key Regulator for Neuronal Survival after Ischemia via TORC1-CREB , 2011, Neuron.

[39]  S. Lehnardt,et al.  Innate immunity and neuroinflammation in the CNS: The role of microglia in Toll‐like receptor‐mediated neuronal injury , 2009, Glia.

[40]  F. Gage,et al.  A Nurr1/CoREST Pathway in Microglia and Astrocytes Protects Dopaminergic Neurons from Inflammation-Induced Death , 2009, Cell.

[41]  F. Crews,et al.  Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration , 2007, Glia.

[42]  S. Lorenzl,et al.  A pivotal role of matrix metalloproteinase‐3 activity in dopaminergic neuronal degeneration via microglial activation , 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[43]  M. Vila,et al.  MPTP as a Mitochondrial Neurotoxic Model of Parkinson's Disease , 2004, Journal of bioenergetics and biomembranes.

[44]  M. Vila,et al.  NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[45]  Ted M. Dawson,et al.  Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease , 1999, Nature Medicine.

[46]  P. Damier,et al.  Glial cells and inflammation in parkinson's disease: A role in neurodegeneration? , 1998, Annals of neurology.

[47]  A. Walch,et al.  ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. , 2017, Nature chemical biology.

[48]  R. Thangavel,et al.  Neuroinflammation Induces Neurodegeneration. , 2016, Journal of neurology, neurosurgery and spine.

[49]  Q. Yuan,et al.  Differential IL-4/Stat6 activities correlate with differential expression of regulatory genes SOCS-1, SHP-1, and PP2A in colon cancer cells , 2008, Journal of Cancer Research and Clinical Oncology.