Successful HLA-identical Unrelated Allogeneic Bone Marrow Transplantation with a very Low Dose of Stem Cells for a Patient with Chronic Myeloid Leukemia in Blast Crisis

The important factors affecting engraftment after bone marrow transplantation (BMT) include infused stem cell dose [1,2], HLA matching [3], stem cell source [4] and T-cell-depletion of graft [5]. BMT with a low dose of marrow cells is at a high risk for graft failure [1,2]. Here we describe a patient who underwent an allogeneic BMT with a very low dose of infused nucleated cells for chronic myeloid leukemia (CML) in blast crisis and achieved delayed engraftment and durable molecular remission.

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