Fungal Biosurfactants from Mortierella alpina.

The zygomycete Mortierella alpina is a well-known producer of polyunsaturated fatty acids in the food industry. Two series of its secondary metabolites are reported: Malpinins, a family of amphiphilic acetylated hexapeptides, were chemically characterized and serve as natural emulsifiers during lipid secretion. Additionally, hydrophobic cyclopentapeptides, malpibaldins, were structurally elucidated by NMR experiments, and their absolute stereochemistry was elucidated through chemical derivatization and synthesis. This work highlights lower fungi as a novel reservoir for natural products.

[1]  F. Rahimi,et al.  Lecithin soybean phospholipid nano‐transfersomes as potential carriers for transdermal delivery of the human growth hormone , 2018, Journal of cellular biochemistry.

[2]  H. Kikukawa,et al.  Arachidonic acid production by the oleaginous fungus Mortierella alpina 1S-4: A review , 2018, Journal of advanced research.

[3]  Ling Jiang,et al.  The Role of Lipid Droplets in Mortierella alpina Aging Revealed by Integrative Subcellular and Whole-Cell Proteome Analysis , 2017, Scientific Reports.

[4]  K. Shin‐ya,et al.  Novel arginine-containing peptides MBJ-0173 and MBJ-0174 from Mortierella alpina f28740 , 2016, The Journal of Antibiotics.

[5]  T. Papp,et al.  15 Genetic and Metabolic Aspects of Primary and Secondary Metabolism of the Zygomycetes , 2016 .

[6]  M. Ohnishi-Kameyama,et al.  Isolation and structure determination of new siderophore albachelin from Amycolatopsis alba , 2015, BioMetals.

[7]  L. Rosa,et al.  Isolation and biological activities of an endophytic Mortierella alpina strain from the Antarctic moss Schistidium antarctici , 2013, Extremophiles.

[8]  P. Hassan,et al.  Self assembled materials: design strategies and drug delivery perspectives. , 2013, Physical chemistry chemical physics : PCCP.

[9]  Hao Zhang,et al.  Genome Characterization of the Oleaginous Fungus Mortierella alpina , 2011, PloS one.

[10]  S. Ōmura,et al.  Calpinactam, a new anti-mycobacterial agent, produced by Mortierella alpina FKI-4905 , 2010, The Journal of Antibiotics.

[11]  S. Ōmura,et al.  Structure and total synthesis of fungal calpinactam, a new antimycobacterial agent. , 2010, Organic letters.

[12]  M. Marahiel,et al.  Erythrochelin – a hydroxamate‐type siderophore predicted from the genome of Saccharopolyspora erythraea , 2010, The FEBS journal.

[13]  C. Schimek,et al.  Carotene derivatives in sexual communication of zygomycete fungi. , 2009, Phytochemistry.

[14]  N. Keller,et al.  Regulation of secondary metabolite production in filamentous ascomycetes. , 2008, Mycological research.

[15]  K. Otrubova,et al.  Synthesis of second-generation sansalvamide A derivatives: novel templates as potential antitumor agents. , 2007, The Journal of organic chemistry.

[16]  K. Otrubova,et al.  Synthesis and novel structure-activity relationships of potent sansalvamide A derivatives. , 2006, Chemical communications.

[17]  S. Reis,et al.  Noninvasive methods to determine the critical micelle concentration of some bile acid salts. , 2004, Analytical biochemistry.

[18]  P. Luisi,et al.  Lecithin organogel as matrix for transdermal transport of drugs. , 1992, Journal of pharmaceutical sciences.

[19]  T. Kamiyama,et al.  Ro 09-1679, a novel thrombin inhibitor. , 1992, The Journal of antibiotics.