Micropump based on electroosmosis of the second kind

A microfluidic pump based on electroosmosis of the second kind was designed and fabricated. Experimental results using DC and AC voltages showed a close to second‐order relationship between flow and voltage, in good agreement with theory. The experimental flow rates were considerably lower than the predicted maximum for the micropumps, which can be attributed to the hydrodynamic resistance of the channel network. This also indicates that higher flow velocities are obtainable for modified pump designs.

[1]  Michael J. Pikal,et al.  The role of electroosmotic flow in transdermal iontophoresis , 1992 .

[2]  M. Bazant,et al.  Induced-charge electro-osmosis , 2003, Journal of Fluid Mechanics.

[3]  L. White,et al.  Lateral separation of colloids or cells by dielectrophoresis augmented by AC electroosmosis. , 2005, Journal of colloid and interface science.

[4]  Purnendu K. Dasgupta,et al.  Electroosmosis: A reliable fluid propulsion system for flow injection analysis , 1994 .

[5]  Hsueh-Chia Chang,et al.  Electrokinetic mixing vortices due to electrolyte depletion at microchannel junctions. , 2003, Journal of colloid and interface science.

[6]  C. Desruisseaux,et al.  Pulsed‐field trapping electrophoresis: A computer simulation study , 1996, Electrophoresis.

[7]  Ulrich Tallarek,et al.  Nonequilibrium electrokinetic effects in beds of ion-permselective particles. , 2004, Langmuir : the ACS journal of surfaces and colloids.

[8]  J. Masliyah,et al.  Oscillating laminar electrokinetic flow in infinitely extended circular microchannels. , 2003, Journal of colloid and interface science.

[9]  F. Ding,et al.  Oscillatory electroosmosis-enhanced intra/inter-particle liquid transport and its primary applications in the preparative electrochromatography of proteins. , 2001, Journal of chromatography. A.

[10]  Stephen C. Jacobson,et al.  Open channel electrochromatography on a microchip , 1994 .

[11]  B. Weigl,et al.  Lab-on-a-chip for drug development. , 2003, Advanced drug delivery reviews.

[12]  S. Dukhin,et al.  Electrophoresis of solid particles at large Peclet numbers , 2002, Electrophoresis.

[13]  N. Mishchuk,et al.  Nonstationary electroosmotic flow in closed cylindrical capillaries , 2006, Electrophoresis.

[14]  A. Dash,et al.  Therapeutic applications of implantable drug delivery systems. , 1998, Journal of pharmacological and toxicological methods.

[15]  M. D. Luque de Castro,et al.  Propelling devices: The heart of flow injection approaches , 2002 .

[16]  M. Bazant,et al.  Induced-charge electrokinetic phenomena: theory and microfluidic applications. , 2003, Physical review letters.

[17]  M. Mpholo,et al.  Low voltage plug flow pumping using anisotropic electrode arrays , 2003 .

[18]  Ivo Nischang,et al.  Perspective on concentration polarization effects in electrochromatographic separations , 2005, Electrophoresis.

[19]  R. Penn,et al.  Cancer pain relief using chronic morphine infusion. Early experience with a programmable implanted drug pump. , 1984, Journal of neurosurgery.

[20]  V. Studer,et al.  An integrated AC electrokinetic pump in a microfluidic loop for fast and tunable flow control. , 2004, The Analyst.

[21]  P. Ellaiah,et al.  Effect of low frequency AC electric fields on urokinase production by MPGN kidney cells , 2003 .

[22]  S. Dukhin,et al.  Intensification of electrodialysis based on electroosmosis of the second kind , 1993 .

[23]  N. Mishchuk,et al.  Electroosmosis of the second kind , 1995 .

[24]  Carl D. Meinhart,et al.  Experimental analysis of particle and fluid motion in ac electrokinetics , 2005 .

[25]  D. DeVoe,et al.  An electrohydrodynamic polarization micropump for electronic cooling , 2001 .

[26]  U. Tallarek,et al.  Effect of Intraparticle Porosity and Double Layer Overlap on Electrokinetic Mobility in Multiparticle Systems , 2003 .

[27]  M. A. Northrup,et al.  Functional integration of PCR amplification and capillary electrophoresis in a microfabricated DNA analysis device. , 1996, Analytical chemistry.

[28]  W. Ehrfeld Electrochemistry and microsystems , 2003 .

[29]  P. Serwer,et al.  Progress in developing improved programs for pulsed field agarose gel electrophoresis of DNA , 1993, Electrophoresis.

[30]  H. Morgan,et al.  Pumping of liquids with traveling-wave electroosmosis , 2005 .

[31]  R. Roberts,et al.  Wave-enhanced interfacial transfer , 2000 .

[32]  Shili Wang,et al.  Electroosmotic pumps and their applications in microfluidic systems , 2009, Microfluidics and nanofluidics.

[33]  J. Eijkel,et al.  An AC electroosmotic micropump for circular chromatographic applications. , 2004, Lab on a chip.

[34]  Ping Wang,et al.  Electrokinetic micropump and micromixer design based on ac faradaic polarization , 2004 .

[35]  E. Lai,et al.  Pulsed field separation of large supercoiled and open‐circular DNAs and its application to bacterial artificial chromosome cloning , 1995, Electrophoresis.

[36]  Honggang Zhu,et al.  Effects of electrophoresis and electroosmosis during alternating current iontophoresis across human epidermal membrane. , 2005, Journal of pharmaceutical sciences.

[37]  S C Jakeway,et al.  Miniaturized total analysis systems for biological analysis , 2000, Fresenius' journal of analytical chemistry.

[38]  Purnendu K. Dasgupta,et al.  Auxiliary electroosmotic pumping in capillary electrophoresis , 1994 .

[39]  Juan G. Santiago,et al.  A planar electroosmotic micropump , 2002 .

[40]  J. Lyklema,et al.  Dynamic Aspects of Electrophoresis and Electroosmosis: A New Fast Method for Measuring Particle Mobilities , 1997 .

[41]  Paul C. H. Li,et al.  Transport, manipulation, and reaction of biological cells on-chip using electrokinetic effects. , 1997, Analytical chemistry.