The effect of motion correction on pharmacokinetic parameter estimation in dynamic-contrast-enhanced MRI

A Dynamic Contrast Enhanced MRI dataset consists of many imaging frames, often both before and after contrast injection Due to the length of image acquisition, patient motion is likely and image re-alignment or registration is required before further analysis such as pharmacokinetic model-fitting Non-rigid image registration procedures may be use to correct motion artefacts, however careful choice of registration strategy is required to reduce mis-registration artefacts associated with enhancing features This work compares the results of two model-fitting algorithms with two registration methods Results show changes to the fitted parameters after motion correction within enhancing regions This preliminary work indicates the importance of careful registration algorithm selection.

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