Chiral Recognition Based on Calixarene by NMR

Calixarens are an important class of host compounds and have extensive applications in host-guest recognition. Especially, chiral calixarene is one of the most interesting research fields in calix- arene chemistry because of its excellent chiral recognition, enantiomer separation and asymmetrical cataly- sis. In the study of chiral recognition, NMR spectrum is the most widely investigated measurement for de- termining ee values and assigning absolute configurations of chiral compounds due to its advantages of convenience, intuition and marked effect, etc. Herein, this paper deals with the latest research progress in the synthesis of chiral receptors based on calixarenes and their applications in the chiral recognition by NMR spectroscopy. In addition, the application prospects of chiral calixarenes are also discussed.