Prevalence and characteristics of anemia in new cases of pulmonary tuberculosis in a tertiary care hospital in Uttarakhand, India

Background : Anemia and tuberculosis (TB) are major public health problems worldwide. The prevalence and characteristics of anemia in TB differ in various studies. The prevalence, type and predictors of anemia in newly diagnosed patients with pulmonary tuberculosis (PTB) and correlation between anemia and various variables concerning PTB were studied. Methods : In this observational, cross-sectional study, 1769 presumptive patients with tuberculosis attending a tertiary care hospital in Uttarakhand, India, were investigated and 242 newly diagnosed (109 sputum-positive and 133 sputum-negative) patients with PTB were selected for further work-up for anemia. Results : Anemia was seen in 72.7% patients and was mild in 44.2%. Anemia of chronic disease was seen in 58.5%, iron deficiency anemia in 26.7%, megaloblastic anemia in 12.5% and dimorphic anemia in 2.2% patients. Both anemia and its severity had significant associations with body mass index (BMI) (p 0.05 each). BMI (r=0.705, p<0.0001) and age (r=0.135, p=0.017) correlated significantly with hemoglobin levels but only BMI was an independent predictor (p<0.0001) of hemoglobin levels. Conclusion : Anemia is common in new patients with PTB and occurs mostly due to chronic disease. It correlates with age and BMI but is only BMI-dependent.

[1]  P. Minchella,et al.  Complex anemia in tuberculosis: the need to consider causes and timing when designing interventions. , 2015, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[2]  A. Mohamedani,et al.  ANEMIA AMONG PATIENTS WITH PULMONARY TUBERCULOSIS IN PORT SUDAN, , 2015 .

[3]  Tsegaye Sewunet,et al.  Immunological Markers and Hematological Parameters among Newly Diagnosed Tuberculosis Patients at Jimma University Specialized Hospital , 2014, Ethiopian journal of health sciences.

[4]  T. Kl.  A Pilot Study on the Detection of Multidrug Resistant Tuberculosis in Hospital Based Population of Chennai, India , 2014 .

[5]  A. Kritski,et al.  Anemia in hospitalized patients with pulmonary tuberculosis , 2014, Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia.

[6]  W. Fawzi,et al.  Anemia at the Initiation of Tuberculosis Therapy Is Associated with Delayed Sputum Conversion among Pulmonary Tuberculosis Patients in Dar-es-Salaam, Tanzania , 2014, PloS one.

[7]  W. Willett,et al.  Iron deficiency and anemia predict mortality in patients with tuberculosis. , 2012, The Journal of nutrition.

[8]  L. Poon,et al.  Body Mass Index Is Associated with Dietary Patterns and Health Conditions in Georgia Centenarians , 2011, Journal of aging research.

[9]  Mahavir Singh,et al.  Comparison of serological responses in two different populations with pulmonary tuberculosis. , 2008, Memorias do Instituto Oswaldo Cruz.

[10]  J. Yim,et al.  The Prevalence and Evolution of Anemia Associated with Tuberculosis , 2006, Journal of Korean medical science.

[11]  Sinha,et al.  DISSEMINATED TUBERCULOSIS AND ABNORMAL HAEMOPOIETIC RESPONSES , 2006 .

[12]  H. Daneschvar,et al.  How to interpret and pursue an abnormal complete blood cell count in adults. , 2005, Mayo Clinic proceedings.

[13]  M. Irfan,et al.  Clinical characteristics of 110 miliary tuberculosis patients from a low HIV prevalence country. , 2004, The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.

[14]  Rajesh Kumar,et al.  Prevalence of anemia in adult rural population of north India. , 2004, The Journal of the Association of Physicians of India.

[15]  A. Tefferi.  Anemia in adults: a contemporary approach to diagnosis. , 2003, Mayo Clinic proceedings.

[16]  H L Rieder,et al.  Global trends in resistance to antituberculosis drugs. World Health Organization-International Union against Tuberculosis and Lung Disease Working Group on Anti-Tuberculosis Drug Resistance Surveillance. , 2001, The New England journal of medicine.

[17]  J. Groopman,et al.  Chemotherapy-induced anemia in adults: incidence and treatment. , 1999, Journal of the National Cancer Institute.

[18]  A. Mansouri,et al.  Anemia in the elderly patient. , 1992, The Medical clinics of North America.

[19]  S. D. Voropaeva.  [Clinical microbiology]. , 2020, Laboratornoe delo.

[20]  M. Hojo,et al.  DIAGNOSTIC AND THERAPEUTIC IMPLICATIONS , 1978 .

[21]  R. Walker,et al.  The significance of hematologic abnormalities in patients with tuberculosis. , 1970, Archives of internal medicine.

[22]  M. G. Nelson,et al.  Disseminated tuberculosis with associated haematological disorders. A report of six cases. , 1969, Irish Journal of Medical Science.