Immunoproliferative Small Intestinal Disease - A Case Report

Malignant lymphomas of the small intestine are relatively common in certain geographic areas and they seem to be particularly so in developing countries, especially in the Middle East and North Africa1.These lymphomas can be divided into 3 subtypes 2 Burkitt lymphoma, Western type of Non-Hodgkin lymphoma and the so called Mediterranean lymphoma. The term Mediterranean lymphoma is a misnomer. The disease mostly occurs in Mediterranean basin but not always3. It was also felt that the disease in its early stages does not appear to be truly malignant lymphoma. So in 1978, WHO recommended the term Immunoproliferative small intestinal disease (IPSID) for the syndrome associated with Mediterranean lymphoma4. Generally, IPSID is considered as a variant of mucosa-associated lymphoid tissue (MALT) lymphoma5. In recent WHO classification, IPSID is listed with heavy chain diseases as a special variant of extra nodal marginal zone B cell lymphoma (MALT) 6.

[1]  T. Al-Saleem,et al.  Immunoproliferative small intestinal disease (IPSID): a model for mature B-cell neoplasms. , 2005, Blood.

[2]  P. Isaacson,et al.  Bacterial infection and MALT lymphoma. , 2004, The New England journal of medicine.

[3]  K. D. Fine,et al.  α-heavy chain disease, Mediterranean lymphoma, and immunoproliferative small intestinal disease: A review of clinicopathological features, pathogenesis, and differential diagnosis , 1999 .

[4]  W. Schmitt,et al.  [Alpha-heavy chain disease--Mediterranean lymphoma]. , 1994, Leber, Magen, Darm.

[5]  J. Spencer,et al.  Immunoproliferative small-intestinal disease. An immunohistochemical study. , 1989, The American journal of surgical pathology.

[6]  D. Dent,et al.  Immunoproliferative Small‐Intestinal Disease: Clinical Features and Outcome in 30 Cases , 1987, Medicine.

[7]  T. Macdonald.  Immunopathology of the Small Intestine , 1987 .

[8]  H. Al-Mondhiry.  Primary lymphomas of the small intestine: East‐west contrast , 1986, American journal of hematology.

[9]  T. Al-Saleem,et al.  Clinical and pathologic subtypes of primary intestinal lymphoma. Experience with 132 patients over a 14‐year period , 1983, Cancer.

[10]  P. Isaacson,et al.  Malignant lymphoma of mucosa‐associated lymphoid tissue. A distinctive type of B‐cell lymphoma , 1983, Cancer.

[11]  I. Zardawi,et al.  Primary lymphomas of the small intestine in Iraq: a pathological study of 145 cases , 1979, Histopathology.

[12]  W. Doe.  Alpha chain disease clinicopathological features and relationship to so-called Mediterranean lymphoma. , 1975, The British journal of cancer. Supplement.

[13]  J. Preud’homme,et al.  Alpha-Chain Disease: A New Immunoglobulin Abnormality , 1968, Science.

[14]  J. Bubis,et al.  MALABSORPTION SYNDROME IN LYMPHOMA OF SMALL INTESTINE. A STUDY OF 13 CASES. , 1965, Israel journal of medical sciences.

[15]  C. Catoi,et al.  TUMORS OF HEMATOPOIETIC AND LYMPHOID TISSUES , 2007 .

[16]  A. Tsapis,et al.  Immunoproliferative small intestinal disease (IPSID): Relationships with α-chain disease and “Mediterranean” lymphomas , 2004, Springer Seminars in Immunopathology.

[17]  P. Isaacson,et al.  Gastrointestinal lymphoma. , 1994, Human pathology.

[18]  J. Rambaud.  Small intestinal lymphomas and alpha-chain disease. , 1983, Clinics in gastroenterology.

[19]  Alpha-chain disease and related small-intestinal lymphoma: a memorandum. , 1976, Bulletin of the World Health Organization.

[20]  H. A. Azar,et al.  Cancer in Lebanon and the near east , 1962, Cancer.

[21]  A. Videbaek.  Malignant lymphoma. , 1950, Acta medica Scandinavica. Supplementum.