Studies on Antifungal Activities of Econazole

T. mentagrophytes conidia were inoculated to the depilated skin of approximate 3cm in diameter on the back of guinea pigs. Topical treatment with a 2% econazole suspension in polyethylene glycol was started 5 days after infection, which was continued 2 weeks. Under such experimental conditions and also in the case of treatment with a 0.5% econazole suspension, a complete cure was attained both clinically and mycologically; lesions developed disappeared, accompanied by becoming negative upon culture as early as almost simultaneously with the completion of treatment. This effect of econazole was equivalent to clotrimazole when compared using their 1% formulation. One percent formulation in cream base also showed a similar potency in this experimental system.

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