Microneedle-based sensors for medical diagnosis.

Recently microneedles have been explored for transdermal monitoring of biomarkers with the goal to achieve time-sensitive clinical information for routine point-of-care health monitoring. In this highlight we provide a general overview of recent progress in microneedle-based sensing research, including: (a) glucose monitoring, (b) ex vitro microneedle diagnostic systems for general health monitoring with an emphasis on sensor construction, and (c) in vivo use of microneedle sensors.

[1]  C. Saudek,et al.  Timing of changes in interstitial and venous blood glucose measured with a continuous subcutaneous glucose sensor. , 2003, Diabetes.

[2]  Mark R Prausnitz,et al.  Minimally invasive extraction of dermal interstitial fluid for glucose monitoring using microneedles. , 2005, Diabetes technology & therapeutics.

[3]  Evgeny Katz,et al.  Bicomponent Microneedle Array Biosensor for Minimally‐Invasive Glutamate Monitoring , 2011 .

[4]  Maelíosa T. C. McCrudden,et al.  Hydrogel-forming microneedles increase in volume during swelling in skin, but skin barrier function recovery is unaffected. , 2014, Journal of pharmaceutical sciences.

[5]  Ronen Polsky,et al.  Multiplexed microneedle-based biosensor array for characterization of metabolic acidosis. , 2012, Talanta.

[6]  Roger Narayan,et al.  Microneedle array-based carbon paste amperometric sensors and biosensors. , 2011, The Analyst.

[7]  Beelee Chua,et al.  Design, Development, and Evaluation of a Novel Microneedle Array-based Continuous Glucose Monitor , 2014, Journal of diabetes science and technology.

[8]  Giuseppe Barillaro,et al.  Microneedles for Transdermal Biosensing: Current Picture and Future Direction , 2015, Advanced healthcare materials.

[9]  Beelee Chua,et al.  Effect of microneedles shape on skin penetration and minimally invasive continuous glucose monitoring in vivo , 2013 .

[10]  Jung-Hwan Park,et al.  Microneedles for drug and vaccine delivery. , 2012, Advanced drug delivery reviews.

[11]  Ronen Polsky,et al.  Integrated carbon fiber electrodes within hollow polymer microneedles for transdermal electrochemical sensing. , 2011, Biomicrofluidics.

[12]  Jacob W. Coffey,et al.  Surface modified microprojection arrays for the selective extraction of the dengue virus NS1 protein as a marker for disease. , 2012, Analytical chemistry.

[13]  Do Hee Keum,et al.  Cancer Detection: Microneedle Biosensor for Real‐Time Electrical Detection of Nitric Oxide for In Situ Cancer Diagnosis During Endomicroscopy (Adv. Healthcare Mater. 8/2015) , 2015 .

[14]  S. D. Collins,et al.  Microneedle array for transdermal biological fluid extraction and in situ analysis , 2004 .

[15]  N. Oliver,et al.  Use of microneedle array devices for continuous glucose monitoring: a review. , 2013, Diabetes technology & therapeutics.

[16]  Benjamin C. Tang,et al.  Microneedle Electrodes Toward an Amperometric Glucose‐Sensing Smart Patch , 2014, Advanced healthcare materials.

[17]  Mark G. Allen,et al.  Lack of pain associated with microfabricated microneedles. , 2001 .

[18]  Roger Narayan,et al.  Microneedle‐Based Transdermal Sensor for On‐Chip Potentiometric Determination of K+ , 2014, Advanced healthcare materials.

[19]  Min-Gon Kim,et al.  One-touch-activated blood multidiagnostic system using a minimally invasive hollow microneedle integrated with a paper-based sensor. , 2015, Lab on a chip.

[20]  Simon R Corrie,et al.  Surface-modified microprojection arrays for intradermal biomarker capture, with low non-specific protein binding. , 2010, Lab on a chip.

[21]  Mark R. Prausnitz,et al.  Collection of Analytes from Microneedle Patches , 2014, Analytical chemistry.

[22]  M. Allen,et al.  Microfabricated microneedles: a novel approach to transdermal drug delivery. , 1998, Journal of pharmaceutical sciences.

[23]  Jacob W. Coffey,et al.  Capture of the circulating Plasmodium falciparum biomarker HRP2 in a multiplexed format, via a wearable skin patch. , 2014, Analytical chemistry.

[24]  R. Potts,et al.  Physiological differences between interstitial glucose and blood glucose measured in human subjects. , 2003, Diabetes care.