Magnesium Level Changes and its Possible Effects on the Outcome of Patients Admitted to Intensive Care Unit

Background: Hypomagnesemia is a usual finding in patients admitted to intensive care unit (ICU) that is usually the result of magnesium (Mg) loss from renal or gastrointestinal (GI) tracts. Objectives: The current study aimed at evaluating the relationship between the level of Mg in serum and outcome of patients admitted to ICU. Methods: The current cross sectional, descriptive study was performed on patients admitted to ICU for 1 year. All of the patients stayed at least 2 days in ICU. Data on the underlying disease were collected based on a check list. All patients were followed-up until the discharge time. Parametric and non-parametric tests were used for the statistical analyses using SPSS software ver. 18.0. Results: One hundred one patients (52 males and 49 females) were enrolled in the current study. Most of the underlying diseases in patients were pulmonary (31.7) and renal (24.8) diseases. Hypomagnesemia and hypermagnesemia were observed in 31.7 and 17.8 of the patients, respectively. Hypomagnesemia was mostly observed in patients with gastrointestinal (50) and renal diseases (36). Among the 101 patients, 71 (70.3) cases died and 30 (29.7) cases were discharged from the hospital. Hypomagnesaemia was observed in 28.1 of dead patients and 40 of the discharged ones. There was no significant correlation between the serum level of Mg and patients outcome. Conclusions: Further studies should be conducted on the total serum Mg and ionized level of Mg in serum, and their correlation with the outcome of patients admitted to ICU. © 2017, Nephrology and Urology Research Center.

[1]  S. Torabian,et al.  Comparison of Serum Levels of Magnesium and Potassium in Stroke Patient and Healthy Controls , 2011 .

[2]  D. Spiegel.  Magnesium in Chronic Kidney Disease: Unanswered Questions , 2011, Blood Purification.

[3]  Philip A Carvil,et al.  Magnesium and Implications on Muscle Function , 2010 .

[4]  J. Hoenderop,et al.  Molecular determinants of magnesium homeostasis: insights from human disease. , 2008, Journal of the American Society of Nephrology : JASN.

[5]  R. Mogulkoc,et al.  Adrenocorticotropic Hormone and Cortisol Levels in Athletes and Sedentary Subjects at Rest and Exhaustion: Effects of Magnesium Supplementation , 2008, Biological Trace Element Research.

[6]  R. Mogulkoc,et al.  Effect of Magnesium Supplementation on Some Plasma Elements in Athletes at Rest and Exhaustion , 2007, Biological Trace Element Research.

[7]  H. Lukaski,et al.  Update on the relationship between magnesium and exercise. , 2006, Magnesium research.

[8]  Y. Arabi,et al.  Magnesium supplementation and the potential association with mortality rates among critically ill non-cardiac patients. , 2006, Saudi medical journal.

[9]  Melvin H. Williams,et al.  Dietary Supplements and Sports Performance: Amino Acids , 2005, Journal of the International Society of Sports Nutrition.

[10]  J. Miller,et al.  Lower serum magnesium levels are associated with more rapid decline of renal function in patients with diabetes mellitus type 2. , 2005, Clinical nephrology.

[11]  R. Rude,et al.  Magnesium Deficiency in Critical Illness , 2005, Journal of intensive care medicine.

[12]  R. Touyz.  Magnesium in clinical medicine. , 2004, Frontiers in bioscience : a journal and virtual library.

[13]  F. Pont,et al.  A compartmental model of magnesium metabolism in healthy men based on two stable isotope tracers. , 2003, American journal of physiology. Regulatory, integrative and comparative physiology.

[14]  T. Ozgurtas,et al.  Monitoring of serum ionized magnesium in neurosurgical intensive care unit: preliminary results. , 2003, Clinica chimica acta; international journal of clinical chemistry.

[15]  Amadeo J Pesce,et al.  Reference intervals: an update. , 2003, Clinica chimica acta; international journal of clinical chemistry.

[16]  H. M. Soliman,et al.  Development of ionized hypomagnesemia is associated with higher mortality rates , 2003, Critical care medicine.

[17]  S. Volpe,et al.  Magnesium and Exercise , 2002, Critical reviews in food science and nutrition.

[18]  I. Nishimoto,et al.  Hypomagnesemia in critically ill cancer patients: a prospective study of predictive factors. , 2000, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

[19]  G T Sanders,et al.  Magnesium levels in critically ill patients. What should we measure? , 2000, American journal of clinical pathology.

[20]  H. Lukaski.  Magnesium, zinc, and chromium nutriture and physical activity. , 2000, The American journal of clinical nutrition.

[21]  K. Geisinger,et al.  Diagnosis and subclassification of primary and recurrent lymphoma. The usefulness and limitations of combined fine-needle aspiration cytomorphology and flow cytometry. , 2000, American journal of clinical pathology.

[22]  M. Van Loan,et al.  The effects of zinc depletion on peak force and total work of knee and shoulder extensor and flexor muscles. , 1999, International journal of sport nutrition.

[23]  L. Tosiello.  Hypomagnesemia and diabetes mellitus. A review of clinical implications. , 1996, Archives of internal medicine.

[24]  M. Graber,et al.  Magnesium deficiency: pathophysiologic and clinical overview. , 1995, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[25]  R. Rude.  Magnesium metabolism and deficiency. , 1993, Endocrinology and metabolism clinics of North America.

[26]  R. Carlson,et al.  Association of Hypomagnesemia and mortality in acutely ill medical patients , 1993, Critical care medicine.

[27]  V. Hoellerich,et al.  Hypomagnesemia in patients in postoperative intensive care. , 1989, Chest.

[28]  E. Fiaccadori,et al.  Muscle and serum magnesium in pulmonary intensive care unit patients. , 1988, Critical care medicine.

[29]  P. W. Wagers,et al.  Magnesium deficiency in a medical ICU population , 1985, Critical care medicine.

[30]  C. Christiansen,et al.  Renal hypomagnesaemia in human diabetes mellitus: its relation to glucose homeostasis , 1982, European journal of clinical investigation.

[31]  G. Utermann.  Genetic disorders of high‐density lipoprotein metabolism and atherosclerosis—what can we learn? , 1982, European journal of clinical investigation.

[32]  W. Henrich,et al.  Recent advances in the prevention and management of intradialytic hypotension. , 2008, Journal of the American Society of Nephrology : JASN.

[33]  S. Bandinelli,et al.  Magnesium and muscle performance in older persons: the InCHIANTI study. , 2006, The American journal of clinical nutrition.

[34]  S. Al-deeb.  Saudi Medical Journal. Maintaining the previous, achieving more PROGRESS , 2006 .

[35]  V. Martínez-Vizcaíno,et al.  Total and ionized serum magnesium in critically ill patients , 2004, Intensive Care Medicine.

[36]  C. Franklin.  Pediatric do-not-resuscitate orders. , 1993, Critical care medicine.

[37]  M. Maguire,et al.  Magnesium as a regulatory cation: criteria and evaluation. , 1987, Magnesium.