Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1.
暂无分享,去创建一个
H. Yamazaki | T. Shimada | S. Amin | F. Guengerich | S. Hecht | T. Sutter | C. L. Hayes | S. Hecht
[1] S. Amin,et al. Tumorigenicity in newborn mice of fjord region and other sterically hindered diol epoxides of benzo[g]chrysene, dibenzo[a,l]pyrene (dibenzo[def,p]chrysene), 4H-cyclopenta[def]chrysene and fluoranthene. , 1995, Carcinogenesis.
[2] S. Amin,et al. Mammary carcinogenicity in female CD rats of fjord region diol epoxides of benzo[c]phenanthrene, benzo[g]chrysene and dibenzo[a,l]pyrene. , 1995, Carcinogenesis.
[3] S. Amin,et al. Mammary carcinogenicity in female CD rats of a diol epoxide metabolite of fluoranthene, a commonly occurring environmental pollutant. , 1995, Carcinogenesis.
[4] G. Clark,et al. Rat CYP1B1: an adrenal cytochrome P450 that exhibits sex-dependent expression in livers and kidneys of TCDD-treated animals. , 1995, Carcinogenesis.
[5] S. Otto,et al. Identification of a rat adrenal cytochrome P450 active in polycyclic hydrocarbon metabolism as rat CYP1B1. Demonstration of a unique tissue- specific pattern of hormonal and aryl hydrocarbon receptor-linked regulation , 1995, The Journal of Biological Chemistry.
[6] R. Tukey,et al. Activation of procarcinogens by human cytochrome P450 enzymes expressed in Escherichia coli. Simplified bacterial systems for genotoxicity assays. , 1994, Carcinogenesis.
[7] T. Shimada,et al. Possible occurrence of P450 related to P450 HFLb in extrahepatic tissues of human fetuses and its contribution to metabolic activation of promutagens. , 1994, Mutation research.
[8] R. Tukey,et al. Expression of modified human cytochrome P450 1A1 in Escherichia coli: effects of 5' substitution, stabilization, purification, spectral characterization, and catalytic properties. , 1994, Archives of biochemistry and biophysics.
[9] H. Yamazaki,et al. Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. , 1994, The Journal of pharmacology and experimental therapeutics.
[10] C. Jefcoate,et al. Mouse cytochrome P-450EF, representative of a new 1B subfamily of cytochrome P-450s. Cloning, sequence determination, and tissue expression. , 1994, The Journal of biological chemistry.
[11] E. Jabs,et al. Complete cDNA sequence of a human dioxin-inducible mRNA identifies a new gene subfamily of cytochrome P450 that maps to chromosome 2. , 1994, The Journal of biological chemistry.
[12] C. Jefcoate,et al. Co-expression of human CYP1A1 and a human analog of cytochrome P450-EF in response to 2,3,7,8-tetrachloro-dibenzo-p-dioxin in the human mammary carcinoma-derived MCF-7 cells. , 1994, Carcinogenesis.
[13] S. Amin,et al. Synthesis of Fjord region diol epoxides as potential ultimate carcinogens of dibenzo[a,l]pyrene. , 1994, Chemical research in toxicology.
[14] R. Tukey,et al. Expression of modified human cytochrome P450 1A2 in Escherichia coli: stabilization, purification, spectral characterization, and catalytic activities of the enzyme. , 1994, Archives of biochemistry and biophysics.
[15] S. Amin,et al. Potent mammary carcinogenicity in female CD rats of a fjord region diol-epoxide of benzo[c]phenanthrene compared to a bay region diol-epoxide of benzo[a]pyrene. , 1994, Cancer research.
[16] P. Beaune,et al. Recombinant yeast in drug metabolism. , 1993, Toxicology.
[17] C. Jefcoate,et al. Mouse endometrium stromal cells express a polycyclic aromatic hydrocarbon-inducible cytochrome P450 that closely resembles the novel P450 in mouse embryo fibroblasts (P450EF). , 1993, Carcinogenesis.
[18] F. Guengerich,et al. Expression of modified human cytochrome P450 3A4 in Escherichia coli and purification and reconstitution of the enzyme. , 1993, Archives of biochemistry and biophysics.
[19] J. Raucy,et al. The expression of xenobiotic-metabolizing cytochromes P450 in fetal tissues. , 1993, Journal of pharmacological and toxicological methods.
[20] C. Jefcoate,et al. Polycyclic aromatic hydrocarbon metabolism in rat adrenal, ovary, and testis microsomes is catalyzed by the same novel cytochrome P450 (P450RAP). , 1992, Endocrinology.
[21] Stephen Naylor,et al. Fluoranthene metabolism: human and rat liver microsomes display different stereoselective formation of the trans-2,3-dihydrodiol. , 1992, Chemical research in toxicology.
[22] P. Beaune,et al. Characterization of human lung microsomal cytochrome P-450 1A1 and its role in the oxidation of chemical carcinogens. , 1992, Molecular pharmacology.
[23] S. Amin,et al. Dimethylchrysene diol epoxides: mutagenicity in Salmonella typhimurium, tumorigenicity in newborn mice, and reactivity with deoxyadenosine in DNA. , 1992, Chemical research in toxicology.
[24] F. Gonzalez,et al. Human cytochromes P450: problems and prospects. , 1992, Trends in pharmacological sciences.
[25] T. Shimada,et al. Activation of Amino-α-carboline, 2-Amino-1-methyl-6-phenylimidazo[4,5- b ]pyridine, and a Copper Phthalocyanine Cellulose Extract of Cigarette Smoke Condensate by Cytochrome P-450 Enzymes in Rat and Human Liver Microsomes , 1991 .
[26] G. Pari,et al. Multiple CArG boxes in the human cardiac actin gene promoter required for expression in embryonic cardiac muscle cells developing in vitro from embryonal carcinoma cells , 1991, Molecular and cellular biology.
[27] T. Shimada,et al. Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes. , 1991, Chemical research in toxicology.
[28] S. Amin,et al. An improved synthesis of anti-benzo[c]phenanthrene-3,4-diol 1,2-epoxide via 4-methoxybenzo[c]phenanthrene , 1990 .
[29] C. Jefcoate,et al. Characterization of a novel cytochrome P450 from the transformable cell line, C3H/10T1/2. , 1990, Carcinogenesis.
[30] L. Marnett,et al. Roles of individual human cytochrome P-450 enzymes in the bioactivation of benzo(a)pyrene, 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and other dihydrodiol derivatives of polycyclic aromatic hydrocarbons. , 1989, Cancer research.
[31] M. Butler,et al. Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines. , 1989, Proceedings of the National Academy of Sciences of the United States of America.
[32] T. Shimada,et al. Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver. , 1989, Proceedings of the National Academy of Sciences of the United States of America.
[33] F. Guengerich. Roles of cytochrome P-450 enzymes in chemical carcinogenesis and cancer chemotherapy. , 1988, Cancer research.
[34] S. Amin,et al. Reactivity with DNA bases and mutagenicity toward Salmonella typhimurium of methylchrysene diol epoxide enantiomers. , 1988, Cancer research.
[35] S. Amin,et al. Oxidation of polynuclear aromatic hydrocarbons with ceric ammonium sulfate: preparation of quinones and lactones , 1988 .
[36] S. Amin,et al. Formation and tumorigenicity of benzo[b]fluoranthene metabolites in mouse epidermis. , 1987, Carcinogenesis.
[37] S. Amin,et al. Enhancing effect of a bay region methyl group on tumorigenicity in newborn mice and mouse skin of enantiomeric bay region diol epoxides formed stereoselectively from methylchrysenes in mouse epidermis. , 1987, Cancer research.
[38] S. Amin,et al. Synthesis of 6-methylchrysene-1,2-diol-3,4-epoxides and comparison of their mutagenicity to 5-methylchrysene-1,2-diol-3,4-epoxides. , 1986, Carcinogenesis.
[39] R. Harvey. Synthesis of the Dihydrodiol and Diol Epoxide Metabolites of Carcinogenic Polycyclic Hydrocarbons , 1986 .
[40] D. Jerina,et al. Tumorigenicity of optical isomers of the diastereomeric bay-region 3,4-diol-1,2-epoxides of benzo(c)phenanthrene in murine tumor models. , 1986, Cancer research.
[41] S. Amin,et al. Effects of 6-nitro substitution on 5-methylchrysene tumorigenicity, mutagenicity and metabolism. , 1986, Carcinogenesis.
[42] R. Tukey,et al. Cloning and isolation of human cytochrome P-450 cDNAs homologous to dioxin-inducible rabbit mRNAs encoding P-450 4 and P-450 6. , 1985, DNA.
[43] D. Nebert,et al. Human dioxin-inducible cytochrome P1-450: complementary DNA and amino acid sequence. , 1985, Science.
[44] R. Harvey,et al. Carcinogenic metabolites of 5-methylchrysene. , 1983, Carcinogenesis.
[45] M. J. Coon,et al. The effect of epoxide hydratase on benzo[a]pyrene diol epoxide hydrolysis and binding to DNA and mixed-function oxidase proteins. , 1981, Molecular pharmacology.
[46] D. Jerina,et al. Mutagenicity and tumorigenicity of phenanthrene and chrysene epoxides and diol epoxides. , 1979, Cancer research.
[47] N. Lauersen,et al. Aryl hydrocarbon hydroxylase activity and microsomal cytochrome content of human fetal tissues. , 1978, Cancer research.
[48] O. Pelkonen. Differential inhibition of aryl hydrocarbon hydroxylase in human foetal liver, adrenal gland and placenta*. , 2009, Acta pharmacologica et toxicologica.
[49] Y. Yasukochi,et al. Some properties of a detergent-solubilized NADPH-cytochrome c(cytochrome P-450) reductase purified by biospecific affinity chromatography. , 1976, The Journal of biological chemistry.
[50] T. Omura,et al. THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE. , 1964, The Journal of biological chemistry.
[51] O. H. Lowry,et al. Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.