Basis for a ubiquitin-like protein thioester switch toggling E1–E2 affinity

[1]  Soichi Wakatsuki,et al.  Ubiquitin-binding domains — from structures to functions , 2009, Nature Reviews Molecular Cell Biology.

[2]  M. Hochstrasser,et al.  Modification of proteins by ubiquitin and ubiquitin-like proteins. , 2006, Annual review of cell and developmental biology.

[3]  A. Haas,et al.  Pleiotropic Effects of ATP·Mg2+ Binding in the Catalytic Cycle of Ubiquitin-activating Enzyme* , 2006, Journal of Biological Chemistry.

[4]  Scott D Emr,et al.  The ESCRT complexes: structure and mechanism of a membrane-trafficking network. , 2006, Annual review of biophysics and biomolecular structure.

[5]  R. Mahley,et al.  Putting cholesterol in its place: apoE and reverse cholesterol transport. , 2006, The Journal of clinical investigation.

[6]  C. Pickart,et al.  Molecular determinants of polyubiquitin linkage selection by an HECT ubiquitin ligase , 2006, The EMBO journal.

[7]  J. Kastelein,et al.  Cholesteryl ester transfer protein (CETP) inhibition beyond raising high-density lipoprotein cholesterol levels: pathways by which modulation of CETP activity may alter atherogenesis. , 2006, Arteriosclerosis, thrombosis, and vascular biology.

[8]  J. Wade Harper,et al.  Structural Complexity in Ubiquitin Recognition , 2006, Cell.

[9]  D. Hoyt,et al.  A UbcH5/ubiquitin noncovalent complex is required for processive BRCA1-directed ubiquitination. , 2006, Molecular cell.

[10]  M. Bamberger,et al.  Description of the torcetrapib series of cholesteryl ester transfer protein inhibitors, including mechanism of actions⃞ , 2006, Journal of Lipid Research.

[11]  M. Hochstrasser.  Lingering Mysteries of Ubiquitin-Chain Assembly , 2006, Cell.

[12]  Brian Kuhlman,et al.  E2 conjugating enzymes must disengage from their E1 enzymes before E3-dependent ubiquitin and ubiquitin-like transfer , 2005, Nature Structural &Molecular Biology.

[13]  James H. Hurley,et al.  Structural mechanism for sterol sensing and transport by OSBP-related proteins , 2005, Nature.

[14]  P. Linsel-Nitschke,et al.  HDL as a target in the treatment of atherosclerotic cardiovascular disease , 2005, Nature Reviews Drug Discovery.

[15]  C. Tomasetto,et al.  Give lipids a START: the StAR-related lipid transfer (START) domain in mammals , 2005, Journal of Cell Science.

[16]  M. Bochtler,et al.  Crystal Structure of a Fragment of Mouse Ubiquitin-activating Enzyme* , 2005, Journal of Biological Chemistry.

[17]  David Reverter,et al.  Insights into E3 ligase activity revealed by a SUMO–RanGAP1–Ubc9–Nup358 complex , 2005, Nature.

[18]  Johnf . Thompson,et al.  Cholesteryl Ester Transfer Protein Variants Have Differential Stability but Uniform Inhibition by Torcetrapib* , 2005, Journal of Biological Chemistry.

[19]  L. V. Van Gaal,et al.  Nicotinic acid in the management of dyslipidaemia associated with diabetes and metabolic syndrome: a position paper developed by a European Consensus Panel , 2005, Current medical research and opinion.

[20]  C. Lima,et al.  Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1 , 2005, The EMBO journal.

[21]  J. Holton,et al.  Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1. , 2005, Molecular cell.

[22]  C. Pickart,et al.  Ubiquitin: structures, functions, mechanisms. , 2004, Biochimica et biophysica acta.

[23]  Xiayang Qiu,et al.  Structure of apo acyl carrier protein and a proposal to engineer protein crystallization through metal ions. , 2004, Acta crystallographica. Section D, Biological crystallography.

[24]  Dinshaw J. Patel,et al.  Structural basis for glycosphingolipid transfer specificity , 2004, Nature.

[25]  David W. Miller,et al.  A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8 , 2004, Nature Structural &Molecular Biology.

[26]  J. Hamilton.  Fatty acid interactions with proteins: what X-ray crystal and NMR solution structures tell us. , 2004, Progress in lipid research.

[27]  D. Rader,et al.  Effects of an inhibitor of cholesteryl ester transfer protein on HDL cholesterol. , 2004, The New England journal of medicine.

[28]  T. Sand,et al.  Raising High-Density Lipoprotein in Humans Through Inhibition of Cholesteryl Ester Transfer Protein: An Initial Multidose Study of Torcetrapib , 2004, Arteriosclerosis, thrombosis, and vascular biology.

[29]  Randy J Read,et al.  Electronic Reprint Biological Crystallography Likelihood-enhanced Fast Rotation Functions Biological Crystallography Likelihood-enhanced Fast Rotation Functions , 2003 .

[30]  B. Peter,et al.  BAR Domains as Sensors of Membrane Curvature: The Amphiphysin BAR Structure , 2004, Science.

[31]  Yi Hou,et al.  A Novel Missense Mutation (L296Q) in Cholesteryl Ester Transfer Protein Gene Related to Coronary Heart Disease , 2004 .

[32]  W. Sundquist,et al.  Retrovirus budding. , 2004, Annual review of cell and developmental biology.

[33]  David W. Miller,et al.  The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1. , 2003, Molecular cell.

[34]  L. Beamer.  Structure of human BPI (bactericidal/permeability-increasing protein) and implications for related proteins. , 2003, Biochemical Society transactions.

[35]  A. Haas,et al.  Conservation in the Mechanism of Nedd8 Activation by the Human AppBp1-Uba3 Heterodimer* , 2003, Journal of Biological Chemistry.

[36]  Bostjan Kobe,et al.  Crystal structures of fusion proteins with large‐affinity tags , 2003, Protein science : a publication of the Protein Society.

[37]  B. Schulman,et al.  Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8 , 2003, Nature.

[38]  D. Rader,et al.  Cholesteryl Ester Transfer Protein: A Novel Target for Raising HDL and Inhibiting Atherosclerosis , 2003, Arteriosclerosis, thrombosis, and vascular biology.

[39]  C. Slaughter,et al.  Identification of a Multifunctional Binding Site on Ubc9p Required for Smt3p Conjugation* , 2002, The Journal of Biological Chemistry.

[40]  C. Ptak,et al.  Structure of a conjugating enzyme-ubiquitin thiolester intermediate reveals a novel role for the ubiquitin tail. , 2001, Structure.

[41]  L. Hicke.  A New Ticket for Entry into Budding Vesicles—Ubiquitin , 2001, Cell.

[42]  W. Boden.  High-density lipoprotein cholesterol as an independent risk factor in cardiovascular disease: assessing the data from Framingham to the Veterans Affairs High--Density Lipoprotein Intervention Trial. , 2000, The American journal of cardiology.

[43]  Alexander Varshavsky,et al.  The ubiquitin system. , 1998, Annual review of biochemistry.

[44]  A. Tall,et al.  Cholesteryl Ester Transfer Protein and Phospholipid Transfer Protein Have Nonoverlapping Functions in Vivo * , 2000, The Journal of Biological Chemistry.

[45]  M. Hochstrasser.  All in the Ubiquitin Family , 2000, Science.

[46]  K. Wakitani,et al.  A cholesteryl ester transfer protein inhibitor attenuates atherosclerosis in rabbits , 2000, Nature.

[47]  T. Wilt,et al.  Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group. , 1999, The New England journal of medicine.

[48]  H. Senn,et al.  Characterization of the binding interface between ubiquitin and class I human ubiquitin-conjugating enzyme 2b by multidimensional heteronuclear NMR spectroscopy in solution. , 1999, Journal of molecular biology.

[49]  R. Morton,et al.  Lipid transfer inhibitor protein defines the participation of lipoproteins in lipid transfer reactions: CETP has no preference for cholesteryl esters in HDL versus LDL. , 1999, Arteriosclerosis, thrombosis, and vascular biology.

[50]  C. Hill,et al.  Crystal Structure of the Human Ubiquitin-like Protein NEDD8 and Interactions with Ubiquitin Pathway Enzymes* , 1998, The Journal of Biological Chemistry.

[51]  R J Read,et al.  Crystallography & NMR system: A new software suite for macromolecular structure determination. , 1998, Acta crystallographica. Section D, Biological crystallography.

[52]  A. Tall,et al.  The implications of the structure of the bactericidal/permeability-increasing protein on the lipid-transfer function of the cholesteryl ester transfer protein. , 1998, Current opinion in structural biology.

[53]  H. Kawasaki,et al.  A new NEDD8-ligating system for cullin-4A. , 1998, Genes & development.

[54]  M. Luo,et al.  Crystal structure of the Saccharomyces cerevisiae phosphatidylinositol- transfer protein , 1998, Nature.

[55]  D Eisenberg,et al.  Crystal structure of human BPI and two bound phospholipids at 2.4 angstrom resolution. , 1997, Science.

[56]  D. Connolly,et al.  Physical and kinetic characterization of recombinant human cholesteryl ester transfer protein. , 1996, The Biochemical journal.

[57]  M. Boguski,et al.  Point mutagenesis of positively charged amino acids of cholesteryl ester transfer protein: conserved residues within the lipid transfer/lipopolysaccharide binding protein gene family essential for function. , 1995, Biochemistry.

[58]  A. Tall,et al.  Molecular determinants of plasma cholesteryl ester transfer protein binding to high density lipoproteins , 1995, The Journal of Biological Chemistry.

[59]  C. Kay,et al.  Modulation of substrate selectivity in plasma lipid transfer protein reaction over structural variation of lipid particle. , 1995, Biochimica et biophysica acta.

[60]  A. Tall,et al.  Defective Binding of Neutral Lipids by a Carboxyl-terminal Deletion Mutant of Cholesteryl Ester Transfer Protein , 1995, The Journal of Biological Chemistry.

[61]  S. Yokoyama,et al.  Triglyceride transfer is required for net cholesteryl ester transfer between lipoproteins in plasma by lipid transfer protein. Evidence for a hetero-exchange transfer mechanism demonstrated by using novel monoclonal antibodies. , 1994, The Journal of biological chemistry.

[62]  Collaborative Computational,et al.  The CCP4 suite: programs for protein crystallography. , 1994, Acta crystallographica. Section D, Biological crystallography.

[63]  C. Pickart,et al.  Substrate properties of site-specific mutant ubiquitin protein (G76A) reveal unexpected mechanistic features of ubiquitin-activating enzyme (E1). , 1994, The Journal of biological chemistry.

[64]  S. Jentsch.  The ubiquitin-conjugation system. , 1992, Annual review of genetics.

[65]  J. Zou,et al.  Improved methods for building protein models in electron density maps and the location of errors in these models. , 1991, Acta crystallographica. Section A, Foundations of crystallography.

[66]  R. Morton,et al.  Concentration of neutral lipids in the phospholipid surface of substrate particles determines lipid transfer protein activity. , 1990, Journal of lipid research.

[67]  D. Gordon,et al.  High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies. , 1989, Circulation.

[68]  A. Haas,et al.  Functional diversity among putative E2 isozymes in the mechanism of ubiquitin-histone ligation. , 1988, The Journal of biological chemistry.

[69]  C. Bugg,et al.  Structure of ubiquitin refined at 1.8 A resolution. , 1987, Journal of molecular biology.

[70]  I. A. Rose,et al.  Functional heterogeneity of ubiquitin carrier proteins. , 1985, The Journal of biological chemistry.

[71]  D. Small,et al.  Surface-to-core and interparticle equilibrium distributions of triglyceride-rich lipoprotein lipids. , 1983, The Journal of biological chemistry.

[72]  J. Hamilton,et al.  Solubilization of triolein and cholesteryl oleate in egg phosphatidylcholine vesicles. , 1983, The Journal of biological chemistry.

[73]  D. B. Zilversmit,et al.  Inter-relationship of lipids transferred by the lipid-transfer protein isolated from human lipoprotein-deficient plasma. , 1983, The Journal of biological chemistry.

[74]  A. Ciechanover,et al.  Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown. , 1983, The Journal of biological chemistry.

[75]  E. Käs,et al.  Deletion of the diploid dihydrofolate reductase locus from cultured mammalian cells , 1983, Cell.

[76]  A. Ciechanover,et al.  Components of Ubiquitin-Protein Ligase System , 1983 .

[77]  A. Haas,et al.  The mechanism of ubiquitin activating enzyme. A kinetic and equilibrium analysis. , 1982, The Journal of biological chemistry.

[78]  J. Hamilton,et al.  Solubilization and localization of cholesteryl oleate in egg phosphatidylcholine vesicles. A carbon 13 NMR study. , 1982, The Journal of biological chemistry.

[79]  A. Hershko,et al.  Ubiquitin-activating enzyme. Mechanism and role in protein-ubiquitin conjugation. , 1982, The Journal of biological chemistry.

[80]  A. Ciechanover,et al.  "Covalent affinity" purification of ubiquitin-activating enzyme. , 1982, The Journal of biological chemistry.

[81]  A. Tall,et al.  Plasma cholesteryl ester transfer protein. , 1993, Journal of lipid research.