Multi-compound polarization by DNP allows simultaneous assessment of multiple enzymatic activities in vivo.

[1]  Sarah E Bohndiek,et al.  Production of hyperpolarized [1,4-13C2]malate from [1,4-13C2]fumarate is a marker of cell necrosis and treatment response in tumors , 2009, Proceedings of the National Academy of Sciences.

[2]  John Kurhanewicz,et al.  Hyperpolarized [2-13C]-fructose: a hemiketal DNP substrate for in vivo metabolic imaging. , 2009, Journal of the American Chemical Society.

[3]  G. Radda,et al.  Real‐time assessment of Krebs cycle metabolism using hyperpolarized C magnetic resonance spectroscopy , 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[4]  Albert P. Chen,et al.  Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading. , 2008, Cancer research.

[5]  F. Gallagher,et al.  13C MR spectroscopy measurements of glutaminase activity in human hepatocellular carcinoma cells using hyperpolarized 13C‐labeled glutamine , 2008, Magnetic resonance in medicine.

[6]  John Kurhanewicz,et al.  Feasibility of using hyperpolarized [1-13C]lactate as a substrate for in vivo metabolic 13C MRSI studies. , 2008, Magnetic resonance imaging.

[7]  Pernille R. Jensen,et al.  Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate , 2008, Nature.

[8]  Craig R. Malloy,et al.  Hyperpolarized 13C allows a direct measure of flux through a single enzyme-catalyzed step by NMR , 2007, Proceedings of the National Academy of Sciences.

[9]  John M Pauly,et al.  Double spin-echo sequence for rapid spectroscopic imaging of hyperpolarized 13C. , 2007, Journal of magnetic resonance.

[10]  S J Kohler,et al.  In vivo 13carbon metabolic imaging at 3T with hyperpolarized 13C‐1‐pyruvate , 2007, Magnetic resonance in medicine.

[11]  Jan Henrik Ardenkjaer-Larsen,et al.  Metabolic imaging by hyperpolarized 13C magnetic resonance imaging for in vivo tumor diagnosis. , 2006, Cancer research.

[12]  E. T. Gawlinski,et al.  Acid-mediated tumor invasion: a multidisciplinary study. , 2006, Cancer research.

[13]  R. Gillies,et al.  Why do cancers have high aerobic glycolysis? , 2004, Nature Reviews Cancer.

[14]  O. Warburg Über die Entstehung der Krebszellen , 1956, Naturwissenschaften.

[15]  J. Ardenkjær-Larsen,et al.  Increase in signal-to-noise ratio of > 10,000 times in liquid-state NMR , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[16]  Jan H. Ardenkjær-Larsen,et al.  Molecular imaging with endogenous substances , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[17]  J S Petersson,et al.  Molecular imaging using hyperpolarized 13C. , 2003, The British journal of radiology.

[18]  J. Kurhanewicz,et al.  Combined magnetic resonance imaging and spectroscopic imaging approach to molecular imaging of prostate cancer , 2002, Journal of magnetic resonance imaging : JMRI.

[19]  S. Nelson,et al.  What is the role of MR spectroscopy in the evaluation and treatment of brain neoplasms? , 1999, AJNR. American journal of neuroradiology.

[20]  A. Palamara,et al.  Loss of GSH, Oxidative Stress, and Decrease of Intracellular pH as Sequential Steps in Viral Infection* , 1997, The Journal of Biological Chemistry.

[21]  S. Simon,et al.  Defective pH regulation of acidic compartments in human breast cancer cells (MCF-7) is normalized in adriamycin-resistant cells (MCF-7adr). , 1996, Biochemistry.

[22]  F. Anet,et al.  The shielding tensor part II: Understanding its strange effects on relaxation , 1992 .

[23]  K A Hossmann,et al.  Imaging of brain tissue pH and metabolites. A new approach for the validation of volume‐selective NMR spectroscopy , 1989, NMR in biomedicine.

[24]  J. Baron,et al.  Tomographic Mapping of Brain Intracellular pH and Extracellular Water Space in Stroke Patients , 1985, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[25]  J. Blicharski Nuclear Magnetic Relaxation by Anisotropy of the Chemical Shift , 1972 .

[26]  O. Warburg [Origin of cancer cells]. , 1956, Oncologia.