The interplay of Hrd3 and the molecular chaperone system ensures efficient degradation of malfolded secretory proteins

A central ubiquitin ligase involved in endoplasmic reticulum (ER)–associated protein degradation is the HRD-ligase. The ER-luminal subunit Hrd3 cooperates with the cochaperone Scj1 in clearing misfolded proteins from the ER.

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