Landfill leachate as a mirror of today's disposable society: Pharmaceuticals and other contaminants of emerging concern in final leachate from landfills in the conterminous United States

Final leachates (leachate after storage or treatment processes) from 22 landfills in 12 states were analyzed for 190 pharmaceuticals and other contaminants of emerging concern (CECs), which were detected in every sample, with the number of CECs ranging from 1 to 58 (median = 22). In total, 101 different CECs were detected in leachate samples, including 43 prescription pharmaceuticals, 22 industrial chemicals, 15 household chemicals, 12 nonprescription pharmaceuticals, 5 steroid hormones, and 4 animal/plant sterols. The most frequently detected CECs were lidocaine (91%, local anesthetic), cotinine (86%, nicotine degradate), carisoprodol (82%, muscle relaxant), bisphenol A (77%, component of plastics and thermal paper), carbamazepine (77%, anticonvulsant), and N,N-diethyltoluamide (68%, insect repellent). Concentrations of CECs spanned 7 orders of magnitude, ranging from 2.0 ng/L (estrone) to 17,200,000 ng/L (bisphenol A). Concentrations of household and industrial chemicals were the greatest (∼1000-1,000,000 ng/L), followed by plant/animal sterols (∼1000-100,000 ng/L), nonprescription pharmaceuticals (∼100-10,000 ng/L), prescription pharmaceuticals (∼10-10,000 ng/L), and steroid hormones (∼10-100 ng/L). The CEC concentrations in leachate from active landfills were significantly greater than those in leachate from closed, unlined landfills (p = 0.05). The CEC concentrations were significantly greater (p < 0.01) in untreated leachate compared with treated leachate. The CEC concentrations were significantly greater in leachate disposed to wastewater treatment plants from modern lined landfills than in leachate released to groundwater from closed, unlined landfills (p = 0.04). The CEC concentrations were significantly greater (p = 0.06) in the fresh leachate (leachate before storage or treatment) reported in a previous study compared with the final leachate sampled for the present study.

[1]  Karen A Kidd,et al.  Collapse of a fish population after exposure to a synthetic estrogen , 2007, Proceedings of the National Academy of Sciences.

[2]  William L. Rathje,et al.  The world's largest landfill , 1992 .

[3]  W. J. Andrews,et al.  Emerging Contaminants at a Closed and an Operating Landfill in Oklahoma , 2012 .

[4]  M. Gavrilescu,et al.  Emerging pollutants in the environment: present and future challenges in biomonitoring, ecological risks and bioremediation. , 2015, New biotechnology.

[5]  L. Barber,et al.  Determination of Steroid Hormones and Related Compounds in Filtered and Unfiltered Water by Solid-Phase Extraction, Derivatization, and Gas Chromatography with Tandem Mass Spectrometry , 2014 .

[6]  C. Richter,et al.  Atrazine reduces reproduction in fathead minnow (Pimephales promelas). , 2010, Aquatic toxicology.

[7]  K. Kümmerer Pharmaceuticals in the Environment , 2001 .

[8]  Michael R. Templeton,et al.  Assessing Exposure and Health Consequences of Chemicals in Drinking Water: Current State of Knowledge and Research Needs , 2013, Environmental health perspectives.

[9]  Ruthann A Rudel,et al.  Pharmaceuticals, perfluorosurfactants, and other organic wastewater compounds in public drinking water wells in a shallow sand and gravel aquifer. , 2014, The Science of the total environment.

[10]  J. Fick,et al.  Dilute Concentrations of a Psychiatric Drug Alter Behavior of Fish from Natural Populations , 2013, Science.

[11]  Ralf Littke,et al.  Occurrence and alteration of organic contaminants in seepage and leakage water from a waste deposit landfill. , 2002, Water research.

[12]  D. Calamari,et al.  Effects of a complex mixture of therapeutic drugs at environmental levels on human embryonic cells. , 2006, Environmental science & technology.

[13]  L. Kong,et al.  Monitoring of 1300 organic micro-pollutants in surface waters from Tianjin, North China. , 2015, Chemosphere.

[14]  C. Martinez,et al.  Assessment of domestic landfill leachate toxicity to the Asian clam Corbicula fluminea via biomarkers. , 2014, Ecotoxicology and environmental safety.

[15]  Jonathon C. Scott,et al.  Chemical mixtures in untreated water from public-supply wells in the U.S.--occurrence, composition, and potential toxicity. , 2012, The Science of the total environment.

[16]  Michael P. Schroeder,et al.  Methods of analysis by the U.S. Geological Survey National Water Quality Laboratory--Determination of wastewater compounds by polystyrene-divinylbenzene solid-phase extraction and capillary-column gas chromatography/mass spectrometry , 2002 .

[17]  E. Furlong,et al.  Determination of human-use pharmaceuticals in filtered water by direct aqueous injection: high-performance liquid chromatography/tandem mass spectrometry , 2014 .

[18]  Kelly R Munkittrick,et al.  Prioritizing contaminants of emerging concern for ecological screening assessments , 2011, Environmental toxicology and chemistry.

[19]  D. Helsel,et al.  Statistical methods in water resources , 2020, Techniques and Methods.

[20]  Heiko L Schoenfuss,et al.  Effects of biologically-active chemical mixtures on fish in a wastewater-impacted urban stream. , 2011, The Science of the total environment.

[21]  J. Fick,et al.  Antihistamines and aquatic insects: bioconcentration and impacts on behavior in damselfly larvae (Zygoptera). , 2014, The Science of the total environment.

[22]  T. Royer,et al.  Pharmaceuticals suppress algal growth and microbial respiration and alter bacterial communities in stream biofilms. , 2013, Ecological applications : a publication of the Ecological Society of America.

[23]  J. Böhlke,et al.  Biogeochemical Evolution of a Landfill Leachate Plume, Norman, Oklahoma , 2011, Ground water.

[24]  A. Ledin,et al.  Xenobiotic organic compounds in leachates from ten Danish MSW landfills--chemical analysis and toxicity tests. , 2004, Water research.

[25]  M I Vasquez,et al.  Environmental side effects of pharmaceutical cocktails: what we know and what we should know. , 2014, Journal of hazardous materials.

[26]  U. Welander Identification by gas chromatography of organic constituents in leachates from sanitary landfills , 1997 .

[27]  N. Paxéus Organic compounds in municipal landfill leachates , 2000 .

[28]  C. Metcalfe,et al.  Interaction of Galaxolide® with the human and trout estrogen receptor-α. , 2010, The Science of the total environment.

[29]  Kyungho Choi,et al.  Pharmaceuticals and Personal Care Products in the Environment: What Are the Big Questions? , 2012, Environmental health perspectives.

[30]  Morton A Barlaz,et al.  Quantitative determination of fluorochemicals in municipal landfill leachates. , 2011, Chemosphere.

[31]  M. Wong,et al.  Pharmaceuticals and personal care products (PPCPs): a review on environmental contamination in China. , 2013, Environment international.

[32]  I. Cozzarelli,et al.  Spatial and Temporal Migration of a Landfill Leachate Plume in Alluvium , 2015, Water, Air, & Soil Pollution.

[33]  R. Klaper,et al.  Metformin Exposure at Environmentally Relevant Concentrations Causes Potential Endocrine Disruption in Adult Male Fish , 2014, Environmental toxicology and chemistry.

[34]  M. Matejczyk,et al.  Estimation of the environmental risk posed by landfills using chemical, microbiological and ecotoxicological testing of leachates. , 2011, Chemosphere.

[35]  M. Reinhard,et al.  Impacts of emerging organic contaminants on freshwater resources: review of recent occurrences, sources, fate and effects. , 2010, The Science of the total environment.

[36]  D. Kolpin,et al.  Pharmaceuticals and Other Organic Waste Water Contaminants Within a Leachate Plume Downgradient of a Municipal Landfill , 2004 .

[37]  Trine Eggen,et al.  Municipal landfill leachates: a significant source for new and emerging pollutants. , 2010, The Science of the total environment.

[38]  P. Fong,et al.  The antidepressants venlafaxine ("Effexor") and fluoxetine ("Prozac") produce different effects on locomotion in two species of marine snail, the oyster drill (Urosalpinx cinerea) and the starsnail (Lithopoma americanum). , 2015, Marine environmental research.

[39]  K. Joseph,et al.  Hazardous organic compounds in urban municipal solid waste from a developing country. , 2008, Journal of hazardous materials.

[40]  I. Cozzarelli,et al.  Contaminants of emerging concern in fresh leachate from landfills in the conterminous United States. , 2014, Environmental science. Processes & impacts.

[41]  Mark Engle,et al.  Discharges of produced waters from oil and gas extraction via wastewater treatment plants are sources of disinfection by-products to receiving streams. , 2014, The Science of the total environment.

[42]  Alon Tal,et al.  Why endocrine disrupting chemicals (EDCs) challenge traditional risk assessment and how to respond. , 2015, Journal of hazardous materials.

[43]  S. Snyder,et al.  The occurrence and fate of chemicals of emerging concern in coastal urban rivers receiving discharge of treated municipal wastewater effluent , 2014, Environmental toxicology and chemistry.

[44]  V. Blazer,et al.  Transgenic Zebrafish Reveal Tissue-Specific Differences in Estrogen Signaling in Response to Environmental Water Samples , 2014, Environmental health perspectives.

[45]  D. Kolpin,et al.  Waste-Indicator and Pharmaceutical Compounds in Landfill-Leachate-Affected Ground Water near Elkhart, Indiana, 2000–2002 , 2009, Bulletin of environmental contamination and toxicology.

[46]  F. Wilcoxon Individual Comparisons by Ranking Methods , 1945 .