TITLE: Integrated assessment of diclofenac biotransformation, pharmacokinetics, and omics-based toxicity in a 3D human liver-immunocompetent co-culture system
暂无分享,去创建一个
D. Lauffenburger | M. Cirit | Dinelia Rivera-Burgos | E. Large | K. Ravindra | Jiajie Yu | J. Wishnok | Steven R. Tannenbaum | Ujjal Sarkar | Carissa L. Young | Jiajie Yu | David J. Hughes | Linda | G. Griffith
[1] David J Hughes,et al. Three-dimensional perfused human in vitro model of non-alcoholic fatty liver disease , 2017, World journal of gastroenterology.
[2] L. Griffith,et al. Modeling Therapeutic Antibody–Small Molecule Drug-Drug Interactions Using a Three-Dimensional Perfusable Human Liver Coculture Platform , 2016, Drug Metabolism and Disposition.
[3] S. Strom,et al. Addition of Dexamethasone Alters the Bile Acid Composition by Inducing CYP8B1 in Primary Cultures of Human Hepatocytes. , 2016, Journal of clinical and experimental hepatology.
[4] Frank Jacobs,et al. In Vitro Model for Hepatotoxicity Studies Based on Primary Human Hepatocyte Cultivation in a Perfused 3D Bioreactor System , 2016, International journal of molecular sciences.
[5] Hong Liang,et al. Structural Basis of Non‐Steroidal Anti‐Inflammatory Drug Diclofenac Binding to Human Serum Albumin , 2015, Chemical biology & drug design.
[6] Georg Damm,et al. Subtoxic Concentrations of Hepatotoxic Drugs Lead to Kupffer Cell Activation in a Human In Vitro Liver Model: An Approach to Study DILI , 2015, Mediators of inflammation.
[7] W. Wong,et al. Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. , 2015, Chemical research in toxicology.
[8] G. Szabo,et al. Inflammasome activation and function in liver disease , 2015, Nature Reviews Gastroenterology &Hepatology.
[9] L. Griffith,et al. Metabolite Profiling and Pharmacokinetic Evaluation of Hydrocortisone in a Perfused Three-Dimensional Human Liver Bioreactor , 2015, Drug Metabolism and Disposition.
[10] Chitra Kanchagar,et al. Establishment of a Hepatocyte-Kupffer Cell Coculture Model for Assessment of Proinflammatory Cytokine Effects on Metabolizing Enzymes and Drug Transporters , 2015, Drug Metabolism and Disposition.
[11] L. Griffith,et al. Spontaneous dormancy of metastatic breast cancer cells in an all human liver microphysiologic system , 2014, British Journal of Cancer.
[12] Adam S. Hayward,et al. Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME , 2013, Archives of Toxicology.
[13] J. Kelm,et al. Multi-cell type human liver microtissues for hepatotoxicity testing , 2012, Archives of Toxicology.
[14] K. Kodys,et al. IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice. , 2012, The Journal of clinical investigation.
[15] Melvin E. Andersen,et al. Organotypic liver culture models: Meeting current challenges in toxicity testing , 2012, Critical reviews in toxicology.
[16] P. Mandrekar,et al. An essential role for monocyte chemoattractant protein‐1 in alcoholic liver injury: Regulation of proinflammatory cytokines and hepatic steatosis in mice , 2011, Hepatology.
[17] J. Houston,et al. Prediction of Human Metabolic Clearance from In Vitro Systems: Retrospective Analysis and Prospective View , 2010, Pharmaceutical Research.
[18] Wajahat Mehal1,et al. Cell Death and Fibrogenesis , 2010, Seminars in liver disease.
[19] Walker Inman,et al. Liver tissue engineering in the evaluation of drug safety , 2009, Expert opinion on drug metabolism & toxicology.
[20] C. Dinarello,et al. Immunological and inflammatory functions of the interleukin-1 family. , 2009, Annual review of immunology.
[21] Pornpimol Charoentong,et al. ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks , 2009, Bioinform..
[22] Albert P. Li,et al. Human hepatocytes: isolation, cryopreservation and applications in drug development. , 2007, Chemico-biological interactions.
[23] J Brian Houston,et al. Evaluation of Cryopreserved Human Hepatocytes as an Alternative in Vitro System to Microsomes for the Prediction of Metabolic Clearance , 2007, Drug Metabolism and Disposition.
[24] Ivan Rusyn,et al. Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesis. , 2006, Toxicological sciences : an official journal of the Society of Toxicology.
[25] K. Sen,et al. Binding of diclofenac sodium with bovine serum albumin at different temperatures, pH and ionic strengths. , 2006, Indian journal of experimental biology.
[26] M. T. Donato,et al. Human hepatocytes in primary culture: the choice to investigate drug metabolism in man. , 2004, Current drug metabolism.
[27] U. Boelsterli,et al. Diclofenac-induced liver injury: a paradigm of idiosyncratic drug toxicity. , 2003, Toxicology and applied pharmacology.
[28] Wei Tang. The metabolism of diclofenac--enzymology and toxicology perspectives. , 2003, Current drug metabolism.
[29] Silvio Albertini,et al. Modulation of gene and protein expression by carbon tetrachloride in the rat liver. , 2002, Toxicology and applied pharmacology.
[30] H. Blum. Molecular Targets for Prevention of Hepatocellular Carcinoma , 2002, Digestive Diseases.
[31] D. Russell,et al. Alternate pathways of bile acid synthesis in the cholesterol 7alpha-hydroxylase knockout mouse are not upregulated by either cholesterol or cholestyramine feeding. , 2001, Journal of lipid research.
[32] I. Björkhem,et al. Bile acid synthesis in cultured human hepatocytes: support for an alternative biosynthetic pathway to cholic acid , 2000, Hepatology.
[33] R. Obach,et al. Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes. , 1999, Drug metabolism and disposition: the biological fate of chemicals.
[34] A Boobis,et al. Hepatic metabolism of diclofenac: role of human CYP in the minor oxidative pathways. , 1999, Biochemical pharmacology.
[35] D J Rance,et al. The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data. , 1997, The Journal of pharmacology and experimental therapeutics.
[36] Tim Morris,et al. Physiological Parameters in Laboratory Animals and Humans , 1993, Pharmaceutical Research.
[37] C. Dinarello,et al. Effect of interleukin-1 (IL-1) blockade on cytokine synthesis: I. IL-1 receptor antagonist inhibits IL-1-induced cytokine synthesis and blocks the binding of IL-1 to its type II receptor on human monocytes. , 1992, Blood.
[38] V. A. Skoutakis,et al. Review of Diclofenac and Evaluation of its Place in Therapy as a Nonsteroidal Antiinflammatory Agent , 1988, Drug intelligence & clinical pharmacy.
[39] R. N. Brogden,et al. Diclofenac Sodium: A Review of its Pharmacological Properties and Therapeutic Use in Rheumatic Diseases and Pain of Varying Origin , 1980, Drugs.
[40] Brad T. Sherman,et al. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources , 2008, Nature Protocols.