to the activation mechanism

Nicolas Le NoveÁ re, Pierre Jean Corringer, Stuart Edelstein, and Jean-Pierre Changeux, Institut Pasteur, URA 2182 CNRS `ReÂcepteurs et Cognition', DeÂpartement des Biotechnologies, 25 rue du Dr Roux, 75724 Paris cedex 15, Universite Pierre et Marie Curie, UMR 7102 CNRS `Neurobiologie des Processus Adaptatifs', 7 quai St Bernard, 75005 Paris, France and DeÂpartement de Biochimie, Universite de GeneÁve, 30 quai Ernest-Ansermet, CH-1211 Geneva 4, Switzerland

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