Physical limits of cell migration: Control by ECM space and nuclear deformation and tuning by proteolysis and traction force

The physical limits of cell migration in dense porous environments are dependent upon the available space and the deformability of the nucleus and are modulated by matrix metalloproteinases, integrins and actomyosin function.

[1]  Olga Ilina,et al.  Two-photon laser-generated microtracks in 3D collagen lattices: principles of MMP-dependent and -independent collective cancer cell invasion , 2011, Physical biology.

[2]  T. Mayadas,et al.  Mac-1 (CD11b/CD18) is essential for Fc receptor-mediated neutrophil cytotoxicity and immunologic synapse formation. , 2001, Blood.

[3]  Frederick Grinnell,et al.  Cell motility and mechanics in three-dimensional collagen matrices. , 2010, Annual review of cell and developmental biology.

[4]  Peter Friedl,et al.  Proteolytic interstitial cell migration: a five-step process , 2009, Cancer and Metastasis Reviews.

[5]  Mikala Egeblad,et al.  Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling , 2009, Cell.

[6]  M. Piel,et al.  Confinement-Optimized 3-Dimensional T cell Amoeboid Motility is Modulated via Myosin IIA-Regulated Adhesions , 2010, Nature Immunology.

[7]  Rachel E. Factor,et al.  The nuclear envelope environment and its cancer connections , 2012, Nature Reviews Cancer.

[8]  P. Friedl,et al.  Intravital third harmonic generation microscopy of collective melanoma cell invasion , 2012, Intravital.

[9]  M. Ringuette,et al.  MT1-MMP is the critical determinant of matrix degradation and invasion by ovarian cancer cells , 2007, British Journal of Cancer.

[10]  A. Huttenlocher,et al.  Adhesion in cell migration. , 1995, Current opinion in cell biology.

[11]  G. Borisy,et al.  Cell Migration: Integrating Signals from Front to Back , 2003, Science.

[12]  Stephen J. Weiss,et al.  Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited , 2009, The Journal of cell biology.

[13]  S. Rizzi,et al.  Elucidating the role of matrix stiffness in 3D cell migration and remodeling. , 2011, Biophysical journal.

[14]  H. Gaub,et al.  Interlaboratory round robin on cantilever calibration for AFM force spectroscopy. , 2011, Ultramicroscopy.

[15]  L. Sander,et al.  An algorithm for extracting the network geometry of three‐dimensional collagen gels , 2008, Journal of microscopy.

[16]  Valerie M. Weaver,et al.  A tense situation: forcing tumour progression , 2009, Nature Reviews Cancer.

[17]  Zhuang Liu,et al.  Drug delivery with carbon nanotubes for in vivo cancer treatment , 2008, 0808.2070.

[18]  Yohei Tanaka,et al.  Long-term histological comparison between near-infrared irradiated skin and scar tissues , 2010, Clinical, cosmetic and investigational dermatology.

[19]  E. Bröcker,et al.  Reconstructing leukocyte migration in 3D extracellular matrix by time-lapse videomicroscopy and computer-assisted tracking. , 2004, Methods in molecular biology.

[20]  D. C. Lin,et al.  Robust strategies for automated AFM force curve analysis-II: adhesion-influenced indentation of soft, elastic materials. , 2007, Journal of biomechanical engineering.

[21]  S. Weiss,et al.  Membrane Type I Matrix Metalloproteinase Usurps Tumor Growth Control Imposed by the Three-Dimensional Extracellular Matrix , 2003, Cell.

[22]  M. Goldberg,et al.  Filaments made from A- and B-type lamins differ in structure and organization , 2008, Journal of Cell Science.

[23]  K. Kadler,et al.  Electron microscopy of collagen fibril structure in vitro and in vivo including three-dimensional reconstruction. , 2008, Methods in cell biology.

[24]  Pierre Validire,et al.  Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors. , 2012, The Journal of clinical investigation.

[25]  K. Yamauchi,et al.  Development of real-time subcellular dynamic multicolor imaging of cancer-cell trafficking in live mice with a variable-magnification whole-mouse imaging system. , 2006, Cancer research.

[26]  Leonard J Foster,et al.  Pseudopodial actin dynamics control epithelial-mesenchymal transition in metastatic cancer cells. , 2010, Cancer research.

[27]  Amber N. Stratman,et al.  MT1-MMP- and Cdc42-dependent signaling co-regulate cell invasion and tunnel formation in 3D collagen matrices , 2009, Journal of Cell Science.

[28]  D. Lauffenburger,et al.  Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[29]  L. Kaufman,et al.  Rheology and confocal reflectance microscopy as probes of mechanical properties and structure during collagen and collagen/hyaluronan self-assembly. , 2009, Biophysical journal.

[30]  Dennis E Discher,et al.  Matrix elasticity, cytoskeletal forces and physics of the nucleus: how deeply do cells ‘feel’ outside and in? , 2010, Journal of Cell Science.

[31]  Claudio G. Rolli,et al.  Impact of Tumor Cell Cytoskeleton Organization on Invasiveness and Migration: A Microchannel-Based Approach , 2010, PloS one.

[32]  Michael P. Sheetz,et al.  The mechanical integrin cycle , 2009, Journal of Cell Science.

[33]  Steven C George,et al.  Noninvasive assessment of collagen gel microstructure and mechanics using multiphoton microscopy. , 2007, Biophysical journal.

[34]  F. Lovat,et al.  The Tumor Suppressor Functions of p27kip1 Include Control of the Mesenchymal/Amoeboid Transition , 2009, Molecular and Cellular Biology.

[35]  F. Grinnell,et al.  The differential regulation of cell motile activity through matrix stiffness and porosity in three dimensional collagen matrices. , 2010, Biomaterials.

[36]  A. Strongin,et al.  Tumor cell invasion through matrigel is regulated by activated matrix metalloproteinase-2. , 1997, Anticancer Research.

[37]  Stephanie Alexander,et al.  Cancer Invasion and the Microenvironment: Plasticity and Reciprocity , 2011, Cell.

[38]  Stefan Schinkinger,et al.  The regulatory role of cell mechanics for migration of differentiating myeloid cells , 2009, Proceedings of the National Academy of Sciences.

[39]  P. Friedl,et al.  The Journal of Cell Biology , 2002 .

[40]  L. Kaufman,et al.  Pore size variable type I collagen gels and their interaction with glioma cells. , 2010, Biomaterials.

[41]  S. Weiss,et al.  Navigating ECM barriers at the invasive front: the cancer cell-stroma interface. , 2009, Annual review of cell and developmental biology.

[42]  Robert D. Goldman,et al.  Actin, microtubules, and vimentin intermediate filaments cooperate for elongation of invadopodia , 2010, The Journal of cell biology.

[43]  N. Romani,et al.  A close-up view of migrating Langerhans cells in the skin. , 2002, The Journal of investigative dermatology.

[44]  Peter Friedl,et al.  Amoeboid shape change and contact guidance: T-lymphocyte crawling through fibrillar collagen is independent of matrix remodeling by MMPs and other proteases. , 2003, Blood.

[45]  M. Ringuette,et al.  Collagen I but not Matrigel matrices provide an MMP-dependent barrier to ovarian cancer cell penetration , 2008, BMC Cancer.

[46]  K. Kaibuchi,et al.  Disruption of Rho signal transduction upon cell detachment , 2004, Journal of Cell Science.

[47]  P. Friedl,et al.  Extracellular matrix determinants of proteolytic and non-proteolytic cell migration. , 2011, Trends in cell biology.

[48]  Steven Shapiro,et al.  Tumor cell traffic through the extracellular matrix is controlled by the membrane-anchored collagenase MT1-MMP , 2004, The Journal of cell biology.

[49]  H. Dvorak,et al.  Neutrophils Emigrate from Venules by a Transendothelial Cell Pathway in Response to FMLP , 1998, The Journal of experimental medicine.

[50]  M. Stack,et al.  Modulation of the Membrane Type 1 Matrix Metalloproteinase Cytoplasmic Tail Enhances Tumor Cell Invasion and Proliferation in Three-dimensional Collagen Matrices* , 2009, The Journal of Biological Chemistry.

[51]  Miguel Vicente-Manzanares,et al.  Segregation and activation of myosin IIB creates a rear in migrating cells , 2008, The Journal of cell biology.

[52]  Dennis E Discher,et al.  The nuclear envelope lamina network has elasticity and a compressibility limit suggestive of a molecular shock absorber , 2004, Journal of Cell Science.

[53]  G. Gerlitz,et al.  The role of chromatin structure in cell migration. , 2011, Trends in cell biology.

[54]  E. Sahai,et al.  Rac Activation and Inactivation Control Plasticity of Tumor Cell Movement , 2008, Cell.

[55]  P. Friedl,et al.  Migration of highly aggressive MV3 melanoma cells in 3-dimensional collagen lattices results in local matrix reorganization and shedding of alpha2 and beta1 integrins and CD44. , 1997, Cancer research.

[56]  Meng Yang,et al.  Real-time in vivo dual-color imaging of intracapillary cancer cell and nucleus deformation and migration. , 2005, Cancer research.

[57]  Coldplay,et al.  X/Y , 2020, The A–Z of Intermarriage.

[58]  Stephanie Alexander,et al.  Dynamic imaging of cancer growth and invasion: a modified skin-fold chamber model , 2008, Histochemistry and Cell Biology.

[59]  K. Stroka,et al.  Physical confinement alters tumor cell adhesion and migration phenotypes , 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[60]  D. Helseth,et al.  Collagen self-assembly in vitro. Differentiating specific telopeptide-dependent interactions using selective enzyme modification and the addition of free amino telopeptide. , 1981, The Journal of biological chemistry.

[61]  David C Lin,et al.  Robust strategies for automated AFM force curve analysis--I. Non-adhesive indentation of soft, inhomogeneous materials. , 2007, Journal of biomechanical engineering.

[62]  Stephen J. Weiss,et al.  Regulation of Cell Invasion and Morphogenesis in a Three-Dimensional Type I Collagen Matrix by Membrane-Type Matrix Metalloproteinases 1, 2, and 3 , 2000, The Journal of cell biology.

[63]  Jacco van Rheenen,et al.  Collagen-based cell migration models in vitro and in vivo. , 2009, Seminars in cell & developmental biology.

[64]  M. Sixt,et al.  Rapid leukocyte migration by integrin-independent flowing and squeezing , 2008, Nature.

[65]  Matthew R. Dallas,et al.  Chemotaxis of Cell Populations through Confined Spaces at Single-Cell Resolution , 2012, PloS one.

[66]  Christopher Beadle,et al.  The role of myosin II in glioma invasion of the brain. , 2008, Molecular biology of the cell.

[67]  Peter Friedl,et al.  Compensation mechanism in tumor cell migration , 2003, The Journal of cell biology.

[68]  Josef A. Käs,et al.  Cell migration through small gaps , 2006, European Biophysics Journal.

[69]  Kenneth M. Yamada,et al.  Direct visualization of protease activity on cells migrating in three-dimensions. , 2009, Matrix Biology.

[70]  M. Stack,et al.  Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion , 2007, Nature Cell Biology.

[71]  S. Nourshargh,et al.  Monocytes and Neutrophils Exhibit Both Distinct and Common Mechanisms in Penetrating the Vascular Basement Membrane In Vivo , 2009, Arteriosclerosis, thrombosis, and vascular biology.

[72]  Jan Lammerding,et al.  Nuclear mechanics during cell migration. , 2011, Current opinion in cell biology.

[73]  Paolo P. Provenzano,et al.  Collagen reorganization at the tumor-stromal interface facilitates local invasion , 2006, BMC medicine.

[74]  D. Weitz,et al.  A blind spot in confocal reflection microscopy: the dependence of fiber brightness on fiber orientation in imaging biopolymer networks. , 2010, Biophysical journal.

[75]  Jennifer L West,et al.  Enhancing mechanical properties of tissue-engineered constructs via lysyl oxidase crosslinking activity. , 2003, Journal of biomedical materials research. Part A.

[76]  Y. Hasegawa,et al.  EGFR-TKI resistance due to BIM polymorphism can be circumvented in combination with HDAC inhibition. , 2013, Cancer research.

[77]  G. Wahl,et al.  Cellular Dynamics Visualized in Live Cells in Vitro and in Vivo by Differential Dual-Color Nuclear-Cytoplasmic Fluorescent-Protein Expression , 2004, Cancer Research.