Extending lifespan by modulating the growth hormone/insulin-like growth factor-1 axis: coming of age

[1]  L. Redman,et al.  Calorie Restriction and Aging in Humans. , 2020, Annual review of nutrition.

[2]  H. Werner,et al.  Effects of GH/IGF on the Aging Mitochondria , 2020, Cells.

[3]  E. Hascup,et al.  Lifespan of long‐lived growth hormone receptor knockout mice was not normalized by housing at 30°C since weaning , 2020, Aging cell.

[4]  Corby K. Martin,et al.  Calorie restriction for enhanced longevity: The role of novel dietary strategies in the present obesogenic environment , 2020, Ageing Research Reviews.

[5]  A. J. van der Lely,et al.  The position of combined medical treatment in acromegaly , 2019, Archives of endocrinology and metabolism.

[6]  F. Aujard,et al.  Caloric restriction, longevity and aging: Recent contributions from human and non-human primate studies , 2019, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[7]  M. Kinter,et al.  Disparate Central and Peripheral Effects of Circulating IGF-1 Deficiency on Tissue Mitochondrial Function , 2019, Molecular Neurobiology.

[8]  M. Blagosklonny Rapamycin for longevity: opinion article , 2019, Aging.

[9]  J. Kopchick,et al.  The effects of growth hormone on therapy resistance in cancer , 2019, Cancer drug resistance.

[10]  E. Davis,et al.  Growth Hormone Upregulates Melanocyte-Inducing Transcription Factor Expression and Activity via JAK2-STAT5 and SRC Signaling in GH Receptor-Positive Human Melanoma , 2019, Cancers.

[11]  V. Loeschcke,et al.  Sex and age specific reduction in stress resistance and mitochondrial DNA copy number in Drosophila melanogaster , 2019, Scientific Reports.

[12]  H. Werner,et al.  Genome-Wide Profiling of Laron Syndrome Patients Identifies Novel Cancer Protection Pathways , 2019, Cells.

[13]  M. Bogue,et al.  Glycine supplementation extends lifespan of male and female mice , 2019, Aging cell.

[14]  B. Miller,et al.  Taming expectations of metformin as a treatment to extend healthspan , 2019, GeroScience.

[15]  S. Melmed,et al.  Excess growth hormone suppresses DNA damage repair in epithelial cells. , 2019, JCI insight.

[16]  G. Fadini,et al.  Modulation of Obesity and Insulin Resistance by the Redox Enzyme and Adaptor Protein p66Shc , 2019, International journal of molecular sciences.

[17]  T. Slaga,et al.  Acarbose improves health and lifespan in aging HET3 mice , 2019, Aging cell.

[18]  C. Sellitto,et al.  Connexin43 mutations linked to skin disease have augmented hemichannel activity , 2019, Scientific Reports.

[19]  A. Dwivedi,et al.  Silencing growth hormone receptor inhibits estrogen receptor negative breast cancer through ATP-binding cassette sub-family G member 2 , 2019, Experimental & Molecular Medicine.

[20]  Emily J. Davis,et al.  Female XX sex chromosomes increase survival and extend lifespan in aging mice , 2018, Aging cell.

[21]  H. Ashida,et al.  Calorie Restriction Mimetics: Upstream-Type Compounds for Modulating Glucose Metabolism , 2018, Nutrients.

[22]  H. Werner,et al.  Mitochondrial Function Is Compromised in Cortical Bone Osteocytes of Long‐Lived Growth Hormone Receptor Null Mice , 2018, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[23]  The Lancet Diabetes & Endocrinology Opening the door to treating ageing as a disease. , 2018, The lancet. Diabetes & endocrinology.

[24]  P. Chanson,et al.  A Consensus Statement on acromegaly therapeutic outcomes , 2018, Nature Reviews Endocrinology.

[25]  J. Gaillard,et al.  Sex gap in aging and longevity: can sex chromosomes play a role? , 2018, Biology of sex differences.

[26]  M. Beibel,et al.  TORC1 inhibition enhances immune function and reduces infections in the elderly , 2018, Science Translational Medicine.

[27]  D. Allison,et al.  Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice , 2018, Nature Communications.

[28]  P. Silveyra,et al.  Sex-specific microRNA expression networks in an acute mouse model of ozone-induced lung inflammation , 2018, Biology of Sex Differences.

[29]  T. Curiel,et al.  A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort: Immunological, physical performance, and cognitive effects , 2018, Experimental Gerontology.

[30]  Zengyi Ma,et al.  Impact of Long-Acting Somatostatin Analogues on Glucose Metabolism in Acromegaly: A Hospital-Based Study , 2018, International journal of endocrinology.

[31]  Xiaowo Wang,et al.  Calorie restriction is the most reasonable anti-ageing intervention: a meta-analysis of survival curves , 2018, Scientific Reports.

[32]  Martha Franco,et al.  Glycine Increases Insulin Sensitivity and Glutathione Biosynthesis and Protects against Oxidative Stress in a Model of Sucrose-Induced Insulin Resistance , 2018, Oxidative medicine and cellular longevity.

[33]  S. Campanaro,et al.  Interplay between gut microbiota and p66Shc affects obesity‐associated insulin resistance , 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[34]  J. Kopchick,et al.  MECHANISMS IN ENDOCRINOLOGY: Lessons from growth hormone receptor gene-disrupted mice: are there benefits of endocrine defects? , 2018, European journal of endocrinology.

[35]  Jie Chen,et al.  Effects of rapamycin on growth hormone receptor knockout mice , 2018, Proceedings of the National Academy of Sciences.

[36]  Mette D. E. Jepsen,et al.  Development of a genetically encodable FRET system using fluorescent RNA aptamers , 2018, Nature Communications.

[37]  C. Boguszewski Update on GH therapy in adults , 2017, F1000Research.

[38]  P. Kapahi,et al.  Dietary restriction and lifespan: Lessons from invertebrate models , 2017, Ageing Research Reviews.

[39]  J. Tower Sex-Specific Gene Expression and Life Span Regulation , 2017, Trends in Endocrinology & Metabolism.

[40]  P. Even,et al.  Disrupting IGF Signaling in Adult Mice Conditions Leanness, Resilient Energy Metabolism, and High Growth Hormone Pulses , 2017, Endocrinology.

[41]  C. Conover,et al.  Inducible knockdown of pregnancy‐associated plasma protein‐A gene expression in adult female mice extends life span , 2017, Aging cell.

[42]  Z. Ungvari,et al.  IGF-1 has sexually dimorphic, pleiotropic, and time-dependent effects on healthspan, pathology, and lifespan , 2017, GeroScience.

[43]  Z. Ungvari,et al.  The GH/IGF-1 axis in a critical period early in life determines cellular DNA repair capacity by altering transcriptional regulation of DNA repair-related genes: implications for the developmental origins of cancer , 2017, GeroScience.

[44]  Amy E. Morgan,et al.  Modelling the molecular mechanisms of aging , 2017, Bioscience reports.

[45]  Zhenguo Liu,et al.  Gender difference in oxidative stress: a new look at the mechanisms for cardiovascular diseases , 2016, Journal of cellular and molecular medicine.

[46]  Randy Strong,et al.  NIA Interventions Testing Program: Investigating Putative Aging Intervention Agents in a Genetically Heterogeneous Mouse Model , 2015, EBioMedicine.

[47]  M. Maghnie,et al.  Classical and non-classical causes of GH deficiency in the paediatric age. , 2016, Best practice & research. Clinical endocrinology & metabolism.

[48]  J. Kopchick,et al.  Disruption of the GH Receptor Gene in Adult Mice Increases Maximal Lifespan in Females. , 2016, Endocrinology.

[49]  L. Philipson,et al.  Growth Hormone-Releasing Hormone in Diabetes , 2016, Front. Endocrinol..

[50]  Dudley Lamming,et al.  Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α‐glucosidase inhibitor or a Nrf2‐inducer , 2016, Aging cell.

[51]  S. Melmed,et al.  Growth hormone is permissive for neoplastic colon growth , 2016, Proceedings of the National Academy of Sciences.

[52]  N. Chevreau Protandim Treatment Causes Reversible Nuclear Translocation of Nrf‐2 and Activation of the Antioxidant Response Element , 2016 .

[53]  Alexandra H. Roberts,et al.  The Effect of Protandim® Supplementation on Athletic Performance and Oxidative Blood Markers in Runners , 2016, PloS one.

[54]  R. de Cabo,et al.  Measures of Healthspan as Indices of Aging in Mice-A Recommendation. , 2016, The journals of gerontology. Series A, Biological sciences and medical sciences.

[55]  P. Ramírez,et al.  Immunosuppressive potency of mechanistic target of rapamycin inhibitors in solid-organ transplantation. , 2016, World journal of transplantation.

[56]  A. Yabluchanskiy,et al.  Differential effects of IGF-1 deficiency during the life span on structural and biomechanical properties in the tibia of aged mice , 2016, AGE.

[57]  S. Simpson,et al.  The impact of low-protein high-carbohydrate diets on aging and lifespan , 2016, Cellular and Molecular Life Sciences.

[58]  R. Granata Peripheral activities of growth hormone-releasing hormone , 2016, Journal of Endocrinological Investigation.

[59]  ALSUntangled No. 31: Protandim , 2016, Amyotrophic lateral sclerosis & frontotemporal degeneration.

[60]  Alaattin Kaya,et al.  Methionine restriction and life‐span control , 2016, Annals of the New York Academy of Sciences.

[61]  S. Bornstein,et al.  Beneficial effects of growth hormone-releasing hormone agonists on rat INS-1 cells and on streptozotocin-induced NOD/SCID mice , 2015, Proceedings of the National Academy of Sciences.

[62]  A. Avogaro,et al.  p66Shc deletion or deficiency protects from obesity but not metabolic dysfunction in mice and humans , 2015, Diabetologia.

[63]  R. de Cabo,et al.  GH Receptor Deficiency in Ecuadorian Adults Is Associated With Obesity and Enhanced Insulin Sensitivity. , 2015, The Journal of clinical endocrinology and metabolism.

[64]  S. Austad,et al.  Sex Differences in Longevity and in Responses to Anti-Aging Interventions: A Mini-Review , 2015, Gerontology.

[65]  M. Vinciguerra,et al.  Interventions to Slow Aging in Humans: Are We Ready? , 2015, Aging cell.

[66]  C. Wrenzycki,et al.  The somatotropic axis during the physiological estrus cycle in dairy heifers--Effect on hepatic expression of GHR and SOCS2. , 2015, Journal of dairy science.

[67]  E. D. de Vries,et al.  Cancer-drug induced insulin resistance: innocent bystander or unusual suspect. , 2015, Cancer treatment reviews.

[68]  H. Warner NIA’s intervention testing program at 10 years of age , 2015, AGE.

[69]  A. J. van der Lely,et al.  Long-term treatment with pegvisomant as monotherapy in patients with acromegaly: experience from ACROSTUDY. , 2015, Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.

[70]  J. Kopchick,et al.  Regulation of mTOR activity in Snell dwarf and GH receptor gene-disrupted mice. , 2015, Endocrinology.

[71]  A. Giustina Optimal use of pegvisomant in acromegaly: are we getting there? , 2015, Endocrine.

[72]  J. DiNicolantonio,et al.  Acarbose, lente carbohydrate, and prebiotics promote metabolic health and longevity by stimulating intestinal production of GLP-1 , 2015, Open Heart.

[73]  J. Praestgaard,et al.  mTOR inhibition improves immune function in the elderly , 2014, Science Translational Medicine.

[74]  Dudley Lamming Diminished mTOR signaling: a common mode of action for endocrine longevity factors , 2014, SpringerPlus.

[75]  James M. Flegal,et al.  Nordihydroguaiaretic Acid Extends the Lifespan of Drosophila and Mice, Increases Mortality-Related Tumors and Hemorrhagic Diathesis, and Alters Energy Homeostasis in Mice , 2014, The journals of gerontology. Series A, Biological sciences and medical sciences.

[76]  J. Kopchick,et al.  Growth hormone signaling is necessary for lifespan extension by dietary methionine , 2014, Aging cell.

[77]  S. Swoap,et al.  Chronic rapamycin treatment causes diabetes in male mice. , 2014, American journal of physiology. Regulatory, integrative and comparative physiology.

[78]  Lilian Chuaire-Noack,et al.  Revisiting the X-Chromosome Inactivation and Its Impact on Female Longevity , 2014 .

[79]  Jihua Tian,et al.  Rapamycin Slows IgA Nephropathy Progression in the Rat , 2014, American Journal of Nephrology.

[80]  M. Levine,et al.  Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. , 2014, Cell metabolism.

[81]  J. Boehm,et al.  Age and cancer risk: a potentially modifiable relationship. , 2014, American journal of preventive medicine.

[82]  Z. D. Sharp,et al.  Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction , 2014, Aging cell.

[83]  B. Ames,et al.  Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males , 2013, Aging cell.

[84]  M. Blagosklonny Immunosuppressants in cancer prevention and therapy , 2013, Oncoimmunology.

[85]  Yimin Fang,et al.  Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice , 2013, eLife.

[86]  S. Melmed,et al.  Growth hormone is a cellular senescence target in pituitary and nonpituitary cells , 2013, Proceedings of the National Academy of Sciences.

[87]  C. Conover,et al.  Inducible knock out of pregnancy-associated plasma protein-a gene expression in the adult mouse: effect on vascular injury response. , 2013, Endocrinology.

[88]  J. Kopchick,et al.  The GH/IGF-1 axis in ageing and longevity , 2013, Nature Reviews Endocrinology.

[89]  Jie Chen,et al.  Duration of rapamycin treatment has differential effects on metabolism in mice. , 2013, Cell metabolism.

[90]  C. Rosak,et al.  Critical evaluation of the role of acarbose in the treatment of diabetes: patient considerations , 2012, Diabetes, metabolic syndrome and obesity : targets and therapy.

[91]  Linda Partridge,et al.  Ageing as a Risk Factor for Disease , 2012, Current Biology.

[92]  H. Brown-Borg,et al.  Expression of oxidative phosphorylation components in mitochondria of long-living Ames dwarf mice , 2012, AGE.

[93]  R. DeFronzo,et al.  Does Reduced IGF-1R Signaling in Igf1r +/− Mice Alter Aging? , 2011, PloS one.

[94]  A. Bartke Pleiotropic effects of growth hormone signaling in aging , 2011, Trends in Endocrinology & Metabolism.

[95]  F. Schena,et al.  Lower Malignancy Rates in Renal Allograft Recipients Converted to Sirolimus-Based, Calcineurin Inhibitor-Free Immunotherapy: 24-Month Results From the CONVERT Trial , 2011, Transplantation.

[96]  K. Sjögren,et al.  Liver-Derived IGF-I Regulates Mean Life Span in Mice , 2011, PloS one.

[97]  Andrew T Chan,et al.  Long-term use of aspirin and the risk of gastrointestinal bleeding. , 2011, The American journal of medicine.

[98]  Z. Laron,et al.  Congenital IGF1 deficiency tends to confer protection against post-natal development of malignancies. , 2011, European journal of endocrinology.

[99]  J. Zweier,et al.  Protandim attenuates intimal hyperplasia in human saphenous veins cultured ex vivo via a catalase-dependent pathway. , 2011, Free radical biology & medicine.

[100]  Federica Madia,et al.  Growth Hormone Receptor Deficiency Is Associated with a Major Reduction in Pro-Aging Signaling, Cancer, and Diabetes in Humans , 2011, Science Translational Medicine.

[101]  R. de Cabo,et al.  Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. , 2011, The journals of gerontology. Series A, Biological sciences and medical sciences.

[102]  A. Waisman,et al.  Metabolic Impact of Adult-Onset, Isolated, Growth Hormone Deficiency (AOiGHD) Due to Destruction of Pituitary Somatotropes , 2011, PloS one.

[103]  A. Bartke Single-gene mutations and healthy ageing in mammals , 2011, Philosophical Transactions of the Royal Society B: Biological Sciences.

[104]  A. Bartke,et al.  Early life growth hormone treatment shortens longevity and decreases cellular stress resistance in long-lived mutant mice. , 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[105]  Y. Appelman,et al.  Gender differences in coronary heart disease , 2010, Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation.

[106]  J. Ramsey,et al.  Honoring Clive McCay and 75 years of calorie restriction research. , 2010, The Journal of nutrition.

[107]  P. Lin,et al.  Molecular mechanisms and clinical applications of nordihydroguaiaretic acid (NDGA) and its derivatives: an update. , 2010, Medical science monitor : international medical journal of experimental and clinical research.

[108]  Linda Partridge,et al.  Extending Healthy Life Span—From Yeast to Humans , 2010, Science.

[109]  Y. Deshaies,et al.  Chronic Rapamycin Treatment Causes Glucose Intolerance and Hyperlipidemia by Upregulating Hepatic Gluconeogenesis and Impairing Lipid Deposition in Adipose Tissue , 2010, Diabetes.

[110]  V. Longo,et al.  Insulin/IGF-I and Related Signaling Pathways Regulate Aging in Nondividing Cells: from Yeast to the Mammalian Brain , 2010, TheScientificWorldJournal.

[111]  H. Hsu,et al.  Long-term administration of rapamycin reduces adiposity, but impairs glucose tolerance in high-fat diet-fed KK/HlJ mice. , 2009, Basic & clinical pharmacology & toxicology.

[112]  S. Melmed,et al.  Rapid and sustained reduction of serum growth hormone and insulin-like growth factor-1 in patients with acromegaly receiving lanreotide Autogel® therapy: a randomized, placebo-controlled, multicenter study with a 52 week open extension , 2009, Pituitary.

[113]  Marco Pahor,et al.  Rapamycin fed late in life extends lifespan in genetically heterogeneous mice , 2009, Nature.

[114]  Liou Y Sun,et al.  Life-span extension in mice by preweaning food restriction and by methionine restriction in middle age. , 2009, The journals of gerontology. Series A, Biological sciences and medical sciences.

[115]  A. Bartke,et al.  Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice. , 2009, The journals of gerontology. Series A, Biological sciences and medical sciences.

[116]  Guohong Li,et al.  Protandim, a Fundamentally New Antioxidant Approach in Chemoprevention Using Mouse Two-Stage Skin Carcinogenesis as a Model , 2009, PloS one.

[117]  A. Bartke,et al.  Alterations in oxygen consumption, respiratory quotient, and heat production in long-lived GHRKO and Ames dwarf mice, and short-lived bGH transgenic mice. , 2009, The journals of gerontology. Series A, Biological sciences and medical sciences.

[118]  C Davatzikos,et al.  Postmenopausal hormone therapy and regional brain volumes , 2009, Neurology.

[119]  Kenneth L. Hensley,et al.  Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice , 2008, Aging cell.

[120]  C. Maldonado-Bernal,et al.  Glycine treatment decreases proinflammatory cytokines and increases interferon-γ in patients with Type 2 diabetes , 2008, Journal of endocrinological investigation.

[121]  P. Pinton,et al.  p66Shc, oxidative stress and aging: Importing a lifespan determinant into mitochondria , 2008, Cell cycle.

[122]  Kenneth L. Hensley,et al.  An aging Interventions Testing Program: study design and interim report , 2007, Aging cell.

[123]  Jianghua Chen,et al.  Rapamycin Prevents Early Steps of the Development of Diabetic Nephropathy in Rats , 2007, American Journal of Nephrology.

[124]  J. Wardlaw,et al.  A prospective, multicentre study to investigate the efficacy, safety and tolerability of octreotide LAR® (long-acting repeatable octreotide) in the primary therapy of patients with acromegaly , 2007, Clinical endocrinology.

[125]  M. Vaysberg,et al.  Rapamycin Inhibits Proliferation of Epstein-Barr Virus–Positive B-cell Lymphomas Through Modulation of Cell-Cycle Protein Expression , 2007, Transplantation.

[126]  Z. Laron,et al.  Patients with congenital deficiency of IGF-I seem protected from the development of malignancies: a preliminary report. , 2007, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

[127]  J. Manson,et al.  Hormone therapy and coronary heart disease: the role of time since menopause and age at hormone initiation. , 2006, Journal of women's health.

[128]  R. Balaban,et al.  The Mammalian Longevity-associated Gene Product p66shc Regulates Mitochondrial Metabolism* , 2006, Journal of Biological Chemistry.

[129]  J. Manson,et al.  Hormone Therapy and Coronary Heart Disease: The Role of Time since Menopause and Age at Hormone Initiation , 2006 .

[130]  G. Grunwald,et al.  The induction of human superoxide dismutase and catalase in vivo: a fundamentally new approach to antioxidant therapy. , 2006, Free radical biology & medicine.

[131]  A. Darweesh,et al.  Complete regression of visceral Kaposi's sarcoma after conversion to sirolimus. , 2005, Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation.

[132]  B. Kahan,et al.  Maintenance Immunosuppression with Target-of-Rapamycin Inhibitors is Associated with a Reduced Incidence of De Novo Malignancies , 2005, Transplantation.

[133]  S. Minucci,et al.  Electron Transfer between Cytochrome c and p66Shc Generates Reactive Oxygen Species that Trigger Mitochondrial Apoptosis , 2005, Cell.

[134]  N. Howell,et al.  Development of 17α‐Estradiol as a Neuroprotective Therapeutic Agent: Rationale and Results from a Phase I Clinical Study , 2005, Annals of the New York Academy of Sciences.

[135]  M. Lipsett,et al.  Disruption of growth hormone receptor gene causes diminished pancreatic islet size and increased insulin sensitivity in mice. , 2004, American journal of physiology. Endocrinology and metabolism.

[136]  R. Salvatori,et al.  A mouse with targeted ablation of the growth hormone-releasing hormone gene: a new model of isolated growth hormone deficiency. , 2004, Endocrinology.

[137]  K. Behar,et al.  Comparing adiposity profiles in three mouse models with altered GH signaling. , 2004, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

[138]  M. Holzenberger The GH/IGF-I axis and longevity. , 2004, European journal of endocrinology.

[139]  Z. Laron,et al.  Laron syndrome (primary growth hormone resistance or insensitivity): the personal experience 1958-2003. , 2004, The Journal of clinical endocrinology and metabolism.

[140]  Amy N Holland,et al.  Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span. , 2003, Endocrinology.

[141]  M. Tatar,et al.  The Endocrine Regulation of Aging by Insulin-like Signals , 2003, Science.

[142]  I. Merchenthaler,et al.  Estrogen prevents the loss of CA1 hippocampal neurons in gerbils after ischemic injury , 2003, Neuroscience.

[143]  K. Sjögren,et al.  Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2 , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[144]  J. Chromiak,et al.  Use of amino acids as growth hormone-releasing agents by athletes. , 2002, Nutrition.

[145]  J. Papaconstantinou,et al.  The Snell dwarf mutation Pit1 dw can increase life span in mice , 2002, Mechanisms of Ageing and Development.

[146]  M. Pollak,et al.  Reduced mammary gland carcinogenesis in transgenic mice expressing a growth hormone antagonist , 2001, British Journal of Cancer.

[147]  G. Striker,et al.  Low-Protein Diet Suppresses Serum Insulin-Like Growth Factor-1 and Decelerates the Progression of Growth Hormone-Induced Glomerulosclerosis , 2001, American Journal of Nephrology.

[148]  G. Pacini,et al.  Liver-derived IGF-I is of importance for normal carbohydrate and lipid metabolism. , 2001, Diabetes.

[149]  Richard A. Miller,et al.  Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[150]  E. Hafen,et al.  Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein , 2001, Science.

[151]  D. Clemmons,et al.  Assessment of growth parameters and life span of GHR/BP gene-disrupted mice. , 2000, Endocrinology.

[152]  Pier Paolo Pandolfi,et al.  The p66shc adaptor protein controls oxidative stress response and life span in mammals , 1999, Nature.

[153]  T. Onouchi,et al.  [Salicylic acid, aspirin]. , 1999, Nihon rinsho. Japanese journal of clinical medicine.

[154]  D. Leroith,et al.  Normal growth and development in the absence of hepatic insulin-like growth factor I. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[155]  K. Sjögren,et al.  Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[156]  A. Bode,et al.  Does growth hormone prevent or accelerate aging? , 1998, Experimental Gerontology.

[157]  T. Wagner,et al.  A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse). , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[158]  Andrzej Bartke,et al.  Dwarf mice and the ageing process , 1996, Nature.

[159]  M. Rosenfeld,et al.  The Ames dwarf gene is required for Pit-1 gene activation. , 1995, Developmental biology.

[160]  J. A. Zimmerman,et al.  Methionine restriction increases blood glutathione and longevity in F344 rats , 1994, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[161]  J. Baker,et al.  Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r) , 1993, Cell.

[162]  R. Wanke,et al.  Effects of long-term elevated serum levels of growth hormone on life expectancy of mice: Lessons from transgenic animal models , 1993, Mechanisms of Ageing and Development.

[163]  J. A. Zimmerman,et al.  Low methionine ingestion by rats extends life span. , 1993, The Journal of nutrition.

[164]  Larry W. Swanson,et al.  Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1 , 1990, Nature.

[165]  J. Jansson,et al.  Sexual dimorphism in the control of growth hormone secretion. , 1985, Endocrine reviews.

[166]  P. Uotila,et al.  Aspirin inhibits arachidonic acid metabolism via lipoxygenase and cyclo-oxygenase in hamster isolated lungs. , 1982, Prostaglandins.

[167]  H. Shiina,et al.  Glycine stimulated growth hormone release in man. , 1980, Acta endocrinologica.

[168]  W. Beamer,et al.  Inherited ateliotic dwarfism in mice. Characteristics of the mutation, little, on chromosome 6. , 1976, The Journal of heredity.

[169]  J. Hamilton,et al.  Mortality and survival: comparison of eunuchs with intact men and women in a mentally retarded population. , 1969, Journal of gerontology.

[170]  Z. Laron,et al.  Pituitary dwarfism with high serum levels of growth hormone. , 1968, Israel journal of medical sciences.

[171]  A. Pertzelan,et al.  Genetic pituitary dwarfism with high serum concentation of growth hormone--a new inborn error of metabolism? , 1966, Israel journal of medical sciences.

[172]  C M McCay,et al.  The effect of retarded growth upon the length of life span and upon the ultimate body size. 1935. , 1935, Nutrition.

[173]  G. Snell DWARF, A NEW MENDELIAN RECESSIVE CHARACTER OF THE HOUSE MOUSE. , 1929, Proceedings of the National Academy of Sciences of the United States of America.

[174]  R. Strong,et al.  NIA Interventions Testing Program: A collaborative approach for investigating interventions to promote healthy aging , 2021, Handbook of the Biology of Aging.

[175]  N. Barzilai,et al.  Dissecting the Mechanisms Underlying Unusually Successful Human Health Span and Life Span. , 2015, Cold Spring Harbor perspectives in medicine.

[176]  Min-Yu Chung,et al.  Two-year body composition analyses of long-lived GHR null mice. , 2010, The journals of gerontology. Series A, Biological sciences and medical sciences.

[177]  Rapamycin hits the target , 2008, Nature Reviews Cancer.

[178]  A. Bartke,et al.  13 Extended Life Span in Mice with Reduction in the GH/IGF-1 Axis , 2008 .

[179]  P. Kelly,et al.  Roles of the lactogens and somatogens in perinatal and postnatal metabolism and growth: studies of a novel mouse model combining lactogen resistance and growth hormone deficiency. , 2005, Endocrinology.

[180]  J. Wright DIABETES MELLITUS | Treatment and Management , 2003 .

[181]  Paul Finglas,et al.  Encyclopedia of food sciences and nutrition , 2003 .

[182]  G. Striker,et al.  Protection against diabetes-induced nephropathy in growth hormone receptor/binding protein gene-disrupted mice. , 2000, Endocrinology.

[183]  G. Striker,et al.  Protection against Diabetes-Induced Nephropathy in Growth Hormone Receptor/Binding Protein Gene-Disrupted Mice1. , 2000, Endocrinology.

[184]  J. Kopchick,et al.  Transgenic models of growth hormone action. , 1999, Annual review of nutrition.