Proteomic characterization of the possible molecular targets of pyrrolizidine alkaloid isoline-induced hepatotoxicity.

[1]  Zhengtao Wang,et al.  The gender-dependent difference of liver GSH antioxidant system in mice and its influence on isoline-induced liver injury. , 2011, Toxicology.

[2]  Zheng-Tao Wang,et al.  Glucuronidation, a new metabolic pathway for pyrrolizidine alkaloids. , 2010, Chemical research in toxicology.

[3]  Zheng-Tao Wang,et al.  In Vitro Metabolism of Isoline, a Pyrrolizidine Alkaloid from Ligularia duciformis, by Rodent Liver Microsomal Esterase and Enhanced Hepatotoxicity by Esterase Inhibitors , 2007, Drug Metabolism and Disposition.

[4]  F. Witzmann,et al.  Two-dimensional gels for toxicological drug discovery applications , 2006, Expert opinion on drug metabolism & toxicology.

[5]  D. Kloor,et al.  Characterization of glycine N-methyltransferase from rabbit liver. , 2004, Biochemistry and cell biology = Biochimie et biologie cellulaire.

[6]  Stewart Bryant,et al.  Toward the identification of liver toxicity markers: A proteome study in human cell culture and rats , 2003, Proteomics.

[7]  NorioNakamura,et al.  Two New Lactones Metabolized from Isoline by Rat Liver Microsomes , 2003 .

[8]  R. S. Sohal,et al.  Mechanisms of aging: an appraisal of the oxidative stress hypothesis. , 2002, Free radical biology & medicine.

[9]  Sandy Kennedy,et al.  Toxicoproteomics -- a new preclinical tool. , 2002, Drug discovery today.

[10]  S. Kennedy.  The role of proteomics in toxicology: identification of biomarkers of toxicity by protein expression analysis , 2002, Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.

[11]  Robert P Tonge,et al.  Genomics and proteomics analysis of acetaminophen toxicity in mouse liver. , 2002, Toxicological sciences : an official journal of the Society of Toxicology.

[12]  Freya Q. Schafer,et al.  Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. , 2001, Free radical biology & medicine.

[13]  Y.Z. Chen,et al.  Ligand–protein inverse docking and its potential use in the computer search of protein targets of a small molecule , 2001, Proteins.

[14]  R. F. Huang,et al.  Folate depletion and elevated plasma homocysteine promote oxidative stress in rat livers. , 2001, The Journal of nutrition.

[15]  M. Parvez,et al.  Structure revision of isoline (ruwenine), bisline and isolinecic acid. , 2000, Phytochemistry.

[16]  M. Stewart,et al.  Clinical and analytical aspects of pyrrolizidine poisoning caused by South African traditional medicines. , 2000, Therapeutic drug monitoring.

[17]  D. Hinshaw,et al.  ATP converts necrosis to apoptosis in oxidant-injured endothelial cells. , 1998, Free radical biology & medicine.

[18]  F. Takusagawa,et al.  Structure, function and physiological role of glycine N-methyltransferase. , 1998, The international journal of biochemistry & cell biology.

[19]  E. Roeder.  Medicinal plants in Europe containing pyrrolizidine alkaloids. , 1995, Die Pharmazie.

[20]  D. Hultquist,et al.  Flavin reductase: sequence of cDNA from bovine liver and tissue distribution. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[21]  T. Hartmann,et al.  Biosynthesis of pyrrolizidine alkaloids: putrescine and spermidine are essential substrates of enzymatic homospermidine formation , 1994 .

[22]  A. Seawright,et al.  Pyrrolizidine alkaloidosis in a two month old foal. , 1993, Zentralblatt fur Veterinarmedizin. Reihe A.

[23]  C. Kumana,et al.  Pyrrolizidine alkaloid composition of three Chinese medicinal herbs, Eupatorium cannabinum, E. japonicum and Crotalaria assamica. , 1992, The American journal of Chinese medicine.

[24]  J. Hrdlička,et al.  The identification of hepatotoxic pyrrolizidine alkaloid exposure in horses by the demonstration of sulphur-bound pyrrolic metabolites on their hemoglobin. , 1991, Veterinary and human toxicology.

[25]  M. Tamura,et al.  Characterization of a second form of NADPH-flavin reductase purified from human erythrocytes. , 1987, Biochemistry international.

[26]  M. Hørder,et al.  International Federation of Clinical Chemistry (IFCC) Scientific Committee, Analytical Section: approved recommendation (1985) on IFCC methods for the measurement of catalytic concentration of enzymes. Part 2. IFCC method for aspartate aminotransferase (L-aspartate: 2-oxoglutarate aminotransferase, , 1986 .

[27]  H. Jörnvall,et al.  Identification of three classes of cytosolic glutathione transferase common to several mammalian species: correlation between structural data and enzymatic properties. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[28]  R. Cook,et al.  Glycine N-methyltransferase is a folate binding protein of rat liver cytosol. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[29]  T. M. Devlin,et al.  Textbook of biochemistry: With clinical correlations , 1982 .

[30]  C. Culvenor,et al.  Plant sources of hepatotoxic pyrrolizidine alkaloids. , 1981, Journal of natural products.

[31]  H. Bergmeyer.  IFCC methods for the measurement of catalytic concentrations of enzymes: Part 3. IFCC method for alanine aminotransferase (L-alanine: 2-oxoglutarate aminotransferase, EC 2.6.1.2)☆ , 1980 .

[32]  M. M. Bradford.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. , 1976, Analytical biochemistry.

[33]  S. Orrenius,et al.  NADPH-dependent reductase solubilized from microsomes by peroxidation and its activity. , 1974, Biochemical and biophysical research communications.

[34]  F. Ismail-Beigi,et al.  The Mechanism of the Calorigenic Action of Thyroid Hormone , 1971, The Journal of general physiology.

[35]  A. Mattocks.  Toxicity of Pyrrolizidine Alkaloids , 1968, Nature.

[36]  G. C. Mills.  Hemoglobin catabolism. I. Glutathione peroxidase, an erythrocyte enzyme which protects hemoglobin from oxidative breakdown. , 1957, The Journal of biological chemistry.