Cross-species molecular dissection across alcohol behavioral domains.

[1]  J. Daunais,et al.  On the relationships in rhesus macaques between chronic ethanol consumption and the brain transcriptome , 2018, Addiction biology.

[2]  G. Koob,et al.  Genetic studies of alcohol dependence in the context of the addiction cycle , 2017, Neuropharmacology.

[3]  K. Grant,et al.  Studies using macaque monkeys to address excessive alcohol drinking and stress interactions , 2017, Neuropharmacology.

[4]  David E. Moorman,et al.  Stress Facilitates the Development of Cognitive Dysfunction After Chronic Ethanol Exposure , 2017, Alcoholism, clinical and experimental research.

[5]  Vladimir I. Vladimirov,et al.  Genomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Ethanol‐Response Behaviors in Model Organisms , 2017, Alcoholism, clinical and experimental research.

[6]  C. Harrington,et al.  Effects of selection for ethanol preference on gene expression in the nucleus accumbens of HS‐CC mice , 2017, Genes, brain, and behavior.

[7]  G. Koob,et al.  A Relationship between the aldosterone - mineralocorticoid receptor pathway and alcohol drinking: preliminary translational findings across rats, monkeys and humans , 2017, Molecular Psychiatry.

[8]  I. Deary,et al.  Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117) , 2017, Molecular Psychiatry.

[9]  M. Miles,et al.  The allostatic impact of chronic ethanol on gene expression: A genetic analysis of chronic intermittent ethanol treatment in the BXD cohort. , 2017, Alcohol.

[10]  Robert W. Williams,et al.  Variable effects of chronic intermittent ethanol exposure on ethanol drinking in a genetically diverse mouse cohort. , 2017, Alcohol.

[11]  Robert W. Williams,et al.  Preface to a special issue on genetic models of alcoholism and alcohol-stress interactions. , 2017, Alcohol.

[12]  Robert W. Williams,et al.  Genetic divergence in the transcriptional engram of chronic alcohol abuse: A laser-capture RNA-seq study of the mouse mesocorticolimbic system. , 2017, Alcohol.

[13]  Robert W. Williams,et al.  Initial genetic dissection of serum neuroactive steroids following chronic intermittent ethanol across BXD mouse strains. , 2017, Alcohol.

[14]  Robert W. Williams,et al.  Differential potassium channel gene regulation in BXD mice reveals novel targets for pharmacogenetic therapies to reduce heavy alcohol drinking. , 2017, Alcohol.

[15]  Peter K. Joshi,et al.  KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference , 2016, Proceedings of the National Academy of Sciences.

[16]  Alessandro Bertolino,et al.  Translating genome-wide association findings into new therapeutics for psychiatry , 2016, Nature Neuroscience.

[17]  A. Lasek.  Effects of Ethanol on Brain Extracellular Matrix: Implications for Alcohol Use Disorder. , 2016, Alcoholism, clinical and experimental research.

[18]  Marc Hafner,et al.  L1000CDS2: LINCS L1000 characteristic direction signatures search engine , 2016, npj Systems Biology and Applications.

[19]  H. Becker,et al.  Effect of different stressors on voluntary ethanol intake in ethanol-dependent and nondependent C57BL/6J mice. , 2016, Alcohol.

[20]  Robert W. Williams,et al.  Joint mouse–human phenome-wide association to test gene function and disease risk , 2016, Nature Communications.

[21]  Peter H. Sudmant,et al.  Meta-analysis of RNA-seq expression data across species, tissues and studies , 2015, Genome Biology.

[22]  J. Bettinger,et al.  Drosophila and Caenorhabditis elegans as Discovery Platforms for Genes Involved in Human Alcohol Use Disorder. , 2015, Alcoholism, clinical and experimental research.

[23]  Ralph Mazitschek,et al.  Treatment of Obesity with Celastrol , 2015, Cell.

[24]  Shannon K. McWeeney,et al.  Cosplicing network analysis of mammalian brain RNA-Seq data utilizing WGCNA and Mantel correlations , 2015, Front. Genet..

[25]  M. Bowers,et al.  Differential response of glial fibrillary acidic protein-positive astrocytes in the rat prefrontal cortex following ethanol self-administration. , 2015, Alcoholism, clinical and experimental research.

[26]  J. Bettinger,et al.  SWI/SNF chromatin remodeling regulates alcohol response behaviors in Caenorhabditis elegans and is associated with alcohol dependence in humans , 2015, Proceedings of the National Academy of Sciences.

[27]  K. Tye,et al.  From circuits to behaviour in the amygdala , 2015, Nature.

[28]  Ryan S. Poland,et al.  Rat Nucleus Accumbens Core Astrocytes Modulate Reward and the Motivation to Self-Administer Ethanol after Abstinence , 2014, Neuropsychopharmacology.

[29]  D. Arasappan,et al.  Transcriptome Organization for Chronic Alcohol Abuse in Human Brain , 2014, Molecular Psychiatry.

[30]  Suzana Herculano-Houzel,et al.  The glia/neuron ratio: How it varies uniformly across brain structures and species and what that means for brain physiology and evolution , 2014, Glia.

[31]  C. Spencer,et al.  Biological Insights From 108 Schizophrenia-Associated Genetic Loci , 2014, Nature.

[32]  S. Treue,et al.  Basic Neuroscience Research with Nonhuman Primates: A Small but Indispensable Component of Biomedical Research , 2014, Neuron.

[33]  J. Bettinger,et al.  Contrasting influences of Drosophila white/mini-white on ethanol sensitivity in two different behavioral assays. , 2014, Alcoholism, clinical and experimental research.

[34]  Robert W. Williams,et al.  Strains and Stressors: An Analysis of Touchscreen Learning in Genetically Diverse Mouse Strains , 2014, PloS one.

[35]  J. Crabbe.  The Genetic Complexity of Alcohol Drinking in Rodents , 2014 .

[36]  F. Collins,et al.  Policy: NIH plans to enhance reproducibility , 2014, Nature.

[37]  B. Grant,et al.  DSM-IV personality disorders and associations with externalizing and internalizing disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions. , 2013, Journal of psychiatric research.

[38]  G. Gessa,et al.  Effects of voluntary alcohol drinking on corticotropin-releasing factor and preprodynorphin mRNA levels in the central amygdala of Sardinian alcohol-preferring rats , 2013, Neuroscience Letters.

[39]  J. Crabbe,et al.  Selection for drinking in the dark alters brain gene coexpression networks. , 2013, Alcoholism, clinical and experimental research.

[40]  K. Mizuno,et al.  Dopamine D1 receptor signaling system regulates ryanodine receptor expression in ethanol physical dependence. , 2013, Alcoholism, clinical and experimental research.

[41]  D. Bottomly,et al.  Genes, behavior and next‐generation RNA sequencing , 2013, Genes, brain, and behavior.

[42]  J. Bettinger,et al.  Ethanol metabolism and osmolarity modify behavioral responses to ethanol in C. elegans. , 2012, Alcoholism, clinical and experimental research.

[43]  E. Tarragon,et al.  Dantrolene blockade of ryanodine receptor impairs ethanol-induced behavioral stimulation, ethanol intake and loss of righting reflex , 2012, Behavioural Brain Research.

[44]  J. Crabbe,et al.  Ethanol tolerance and withdrawal severity in high drinking in the dark selectively bred mice. , 2012, Alcoholism, clinical and experimental research.

[45]  Daniel Bottomly,et al.  Utilizing RNA-Seq data for de novo coexpression network inference , 2012, Bioinform..

[46]  J. Bettinger,et al.  Chloride intracellular channels modulate acute ethanol behaviors in Drosophila, Caenorhabditis elegans and mice , 2012, Genes, brain, and behavior.

[47]  J. Bettinger,et al.  Lipid Environment Modulates the Development of Acute Tolerance to Ethanol in Caenorhabditis elegans , 2012, PloS one.

[48]  Michael A. Langston,et al.  Genetic Dissection of Acute Ethanol Responsive Gene Networks in Prefrontal Cortex: Functional and Mechanistic Implications , 2012, PloS one.

[49]  Robert W. Williams,et al.  Complex Control of GABA(A) Receptor Subunit mRNA Expression: Variation, Covariation, and Genetic Regulation , 2012, PloS one.

[50]  Allan R. Jones,et al.  Transcriptional Architecture of the Primate Neocortex , 2012, Neuron.

[51]  Dardo Tomasi,et al.  Addiction circuitry in the human brain. , 2012, Annual review of pharmacology and toxicology.

[52]  Manuel Mattheisen,et al.  Genome‐wide significant association between alcohol dependence and a variant in the ADH gene cluster , 2012, Addiction biology.

[53]  A. Bahi,et al.  Involvement of tissue plasminogen activator “tPA” in ethanol-induced locomotor sensitization and conditioned-place preference , 2012, Behavioural Brain Research.

[54]  Sarah E. Medland,et al.  A Quantitative-Trait Genome-Wide Association Study of Alcoholism Risk in the Community: Findings and Implications , 2011, Biological Psychiatry.

[55]  K. Kendler,et al.  Alcohol dependence in men: reliability and heritability. , 2011, Alcoholism, clinical and experimental research.

[56]  B. Walker,et al.  Plasticity associated with escalated operant ethanol self-administration during acute withdrawal in ethanol-dependent rats requires intact matrix metalloproteinase systems , 2011, Neurobiology of Learning and Memory.

[57]  Alexander A. Morgan,et al.  Computational Repositioning of the Anticonvulsant Topiramate for Inflammatory Bowel Disease , 2011, Science Translational Medicine.

[58]  P. O’Reilly,et al.  Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption , 2011, Proceedings of the National Academy of Sciences.

[59]  I. Veldhuizen,et al.  Cardiovascular and demographic characteristics in whole blood and plasma donors: results from the Donor InSight study , 2011, Transfusion.

[60]  G. Koob,et al.  Preclinical studies of alcohol binge drinking , 2011, Annals of the New York Academy of Sciences.

[61]  M. Shibasaki,et al.  Regulation of ryanodine receptors by dopamine D1 receptors during methamphetamine‐induced place conditioning , 2010, Journal of neurochemistry.

[62]  Yun Li,et al.  METAL: fast and efficient meta-analysis of genomewide association scans , 2010, Bioinform..

[63]  W. Hao,et al.  The relationship between self-reported drinking and BAC level in emergency room injury cases: is it a straight line? , 2010, Alcoholism, clinical and experimental research.

[64]  Marc A Schuckit,et al.  Genome-wide association study of alcohol dependence implicates a region on chromosome 11. , 2010, Alcoholism, clinical and experimental research.

[65]  Raymond L. White,et al.  Human variation in alcohol response is influenced by variation in neuronal signaling genes. , 2010, Alcoholism, clinical and experimental research.

[66]  Robert W. Williams,et al.  Strain Differences in Stress Responsivity Are Associated with Divergent Amygdala Gene Expression and Glutamate-Mediated Neuronal Excitability , 2010, The Journal of Neuroscience.

[67]  K. Tye,et al.  Reduced Nucleus Accumbens SK Channel Activity Enhances Alcohol Seeking during Abstinence , 2010, Neuron.

[68]  E. Chesler,et al.  High-throughput behavioral phenotyping in the expanded panel of BXD recombinant inbred strains , 2010, Genes, brain, and behavior.

[69]  Robert W. Williams.  Herding Cats: The Sociology of Data Integration , 2009, Frontiers in Neuroscience.

[70]  S. Cichon,et al.  Genome-wide association study of alcohol dependence. , 2009, Archives of general psychiatry.

[71]  Lu Lu,et al.  Dissection of a QTL Hotspot on Mouse Distal Chromosome 1 that Modulates Neurobehavioral Phenotypes and Gene Expression , 2008, PLoS genetics.

[72]  A. Parrill,et al.  Ethanol Modulates BKCa Channels by Acting as an Adjuvant of Calcium , 2008, Molecular Pharmacology.

[73]  P. Janak,et al.  Nucleus accumbens AGS3 expression drives ethanol seeking through Gβγ , 2008, Proceedings of the National Academy of Sciences.

[74]  J. Bettinger,et al.  Loss of RAB‐3/A in Caenorhabditis elegans and the mouse affects behavioral response to ethanol , 2008, Genes, brain, and behavior.

[75]  Wei Wang,et al.  The polymorphism architecture of mouse genetic resources elucidated using genome-wide resequencing data: implications for QTL discovery and systems genetics , 2007, Mammalian Genome.

[76]  T. Thornton,et al.  Case-control association testing with related individuals: a more powerful quasi-likelihood score test. , 2007, American journal of human genetics.

[77]  P. Donnelly,et al.  A new multipoint method for genome-wide association studies by imputation of genotypes , 2007, Nature Genetics.

[78]  Elizabeth L. Ogburn,et al.  Prevalence, correlates, disability, and comorbidity of DSM-IV alcohol abuse and dependence in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions. , 2007, Archives of general psychiatry.

[79]  David N. Messina,et al.  Evolutionary and Biomedical Insights from the Rhesus Macaque Genome , 2007, Science.

[80]  Thomas A Trikalinos,et al.  Implications of small effect sizes of individual genetic variants on the design and interpretation of genetic association studies of complex diseases. , 2006, American journal of epidemiology.

[81]  Paul A Clemons,et al.  The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease , 2006, Science.

[82]  Michael O. Hengartner,et al.  Finding function in novel targets: C. elegans as a model organism , 2006, Nature Reviews Drug Discovery.

[83]  Megan K. Mulligan,et al.  Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[84]  Jean L. Chang,et al.  Initial sequence of the chimpanzee genome and comparison with the human genome , 2005, Nature.

[85]  Robert W. Williams,et al.  Complex genetics of interactions of alcohol and CNS function and behavior. , 2005, Alcoholism, clinical and experimental research.

[86]  G. Vogler,et al.  The Washington University Twin Study of alcoholism , 2005, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[87]  Robert W. Williams,et al.  Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function , 2005, Nature Genetics.

[88]  Sidney Strickland,et al.  Ethanol-withdrawal seizures are controlled by tissue plasminogen activator via modulation of NR2B-containing NMDA receptors. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[89]  J. Bettinger,et al.  Natural Variation in the npr-1 Gene Modifies Ethanol Responses of Wild Strains of C. elegans , 2004, Neuron.

[90]  Tod R. Thiele,et al.  A Central Role of the BK Potassium Channel in Behavioral Responses to Ethanol in C. elegans , 2003, Cell.

[91]  J. Sikela,et al.  A strategy for the integration of QTL, gene expression, and sequence analyses , 2003, Mammalian Genome.

[92]  J. Crabbe,et al.  Chromosomal loci influencing chronic alcohol withdrawal severity , 2003, Mammalian Genome.

[93]  Thomas A Trikalinos,et al.  Genetic associations in large versus small studies: an empirical assessment , 2003, The Lancet.

[94]  E. Lander,et al.  Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease , 2003, Nature Genetics.

[95]  J. Crabbe.  Alcohol and genetics: new models. , 2002, American journal of medical genetics.

[96]  J. Sikela,et al.  Quantitative trait loci affecting initial sensitivity and acute functional tolerance to ethanol-induced ataxia and brain cAMP signaling in BXD recombinant inbred mice. , 2002, The Journal of pharmacology and experimental therapeutics.

[97]  J. Belknap,et al.  The replicability of QTLs for murine alcohol preference drinking behavior across eight independent studies , 2001, Mammalian Genome.

[98]  J. Ioannidis,et al.  Replication validity of genetic association studies , 2001, Nature Genetics.

[99]  A. Bosserhoff,et al.  Induction of AP-2α Expression by Adenoviral Infection Involves Inactivation of the AP-2rep Transcriptional Corepressor CtBP1* , 2001, The Journal of Biological Chemistry.

[100]  D. J. Matthews,et al.  Using model-system genetics for drug-based target discovery. , 2001, Drug discovery today.

[101]  J. Crabbe,et al.  Genetics of mouse behavior: interactions with laboratory environment. , 1999, Science.

[102]  D. Brownlee,et al.  Exploring the neurotransmitter labyrinth in nematodes , 1999, Trends in Neurosciences.

[103]  Cori Bargmann.  Neurobiology of the Caenorhabditis elegans genome. , 1998, Science.

[104]  G. Mcclearn,et al.  High genetic susceptibility to ethanol withdrawal predicts low ethanol consumption , 1998, Mammalian Genome.

[105]  T. Smith,et al.  The relationship between Self-Rating of the Effects of alcohol and alcohol challenge results in ninety-eight young men. , 1997, Journal of studies on alcohol.

[106]  C. Robert Cloninger,et al.  Replication of the Stockholm Adoption Study of alcoholism. Confirmatory cross-fostering analysis. , 1996, Archives of general psychiatry.

[107]  N. R. Richardson,et al.  Progressive ratio schedules in drug self-administration studies in rats: a method to evaluate reinforcing efficacy , 1996, Journal of Neuroscience Methods.

[108]  G. Mcclearn,et al.  Alcohol acceptance, preference, and sensitivity in mice. I. Quantitative genetic analysis using BXD recombinant inbred strains. , 1994, Alcoholism, clinical and experimental research.

[109]  J. Crabbe,et al.  Localization of genes affecting alcohol drinking in mice. , 1994, Alcoholism, clinical and experimental research.

[110]  J. Nurnberger,et al.  A new, semi-structured psychiatric interview for use in genetic linkage studies: a report on the reliability of the SSAGA. , 1994, Journal of studies on alcohol.

[111]  R. Crowe.  Candidate genes in psychiatry: an epidemiological perspective. , 1993, American journal of medical genetics.

[112]  G. Mcclearn,et al.  Differences in Alcohol Preference among Inbred Strains of Mice , 1959 .

[113]  I. Deary,et al.  Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank , 2017 .

[114]  R. Harris,et al.  Genes and Alcohol Consumption: Studies with Mutant Mice. , 2016, International review of neurobiology.

[115]  L A Farrer,et al.  Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci , 2014, Molecular Psychiatry.

[116]  A. Smit,et al.  Neural ECM in addiction, schizophrenia, and mood disorder. , 2014, Progress in brain research.

[117]  M. Potenza,et al.  Similarities and differences between pathological gambling and substance use disorders: a focus on impulsivity and compulsivity , 2011, Psychopharmacology.

[118]  R. Hitzemann,et al.  Strategies To Study The Neuroscience of Alcoholism: Introduction , 2008, Alcohol Research and Health.

[119]  J. Crabbe,et al.  Polygenic and single-gene determination of responses to ethanol in BXD/Ty recombinant inbred mouse strains. , 1983, Neurobehavioral toxicology and teratology.

[120]  N S Cotton,et al.  The familial incidence of alcoholism: a review. , 1979, Journal of studies on alcohol.

[121]  HighWire Press,et al.  The journal of pharmacology and experimental therapeutics , 1909 .