Appendiceal Goblet Cell Carcinoid Tumour: A Case of Unexpected Lung Metastasis

Goblet cell carcinoid tumours are often considered a subset of appendiceal neuroendocrine tumours which behave more aggressively. They usually metastasize through transcoelomic/peritoneal invasion and common sites include the ovaries, peritoneum, and liver. Metastases may have goblet cell carcinoid, signet ring cell carcinoma or classic carcinoid histology. We report the first case in the literature of a patient with a goblet cell carcinoid with lung metastasis, which was associated with unfavourable outcome.

[1]  T. Gress,et al.  ENETS Consensus Guidelines for the Management of Patients with Neuroendocrine Neoplasms from the Jejuno-Ileum and the Appendix Including Goblet Cell Carcinomas , 2011, Neuroendocrinology.

[2]  D. Henson,et al.  Pathologic classification and clinical behavior of the spectrum of goblet cell carcinoid tumors of the appendix. , 2009, The American journal of surgical pathology.

[3]  K. Das,et al.  Cytology of metastatic appendiceal goblet cell carcinoid in pleural effusion fluid: A case report , 2008, Diagnostic cytopathology.

[4]  M. Falconi,et al.  Consensus Guidelines for the Management of Patients with Digestive Neuroendocrine Tumours: Well-Differentiated Tumour/Carcinoma of the Appendix and Goblet Cell Carcinoma , 2007, Neuroendocrinology.

[5]  R. Standish,et al.  Goblet Cell Carcinoid Tumors (Adenocarcinoid) of the Appendix , 2007, Diseases of the colon and rectum.

[6]  P. Sugarbaker,et al.  Treatment of peritoneal carcinomatosis from adenocarcinoid of appendiceal origin , 2004, The British journal of surgery.

[7]  J. Raoul,et al.  CASE REPORT: Adenocarcinoid of the Appendix Vermiformis: Complete and Persistent Remission After Chemotherapy (Folfox) of a Metastatic Case , 2002, Digestive Diseases and Sciences.

[8]  Xinjun Li,et al.  Incidence trends and risk factors of carcinoid tumors , 2001, Cancer.

[9]  R. Kanthan,et al.  Goblet cell carcinoids of the appendix: immunophenotype and ultrastructural study. , 2001, Archives of pathology & laboratory medicine.

[10]  P. Argani,et al.  Diagnosis of metastatic appendiceal adenocarcinoid in liver by fine‐needle aspiration cytology , 1995, Diagnostic cytopathology.

[11]  M. Fujimaki,et al.  [Goblet cell carcinoid of the appendix]. , 1986, Gan no rinsho. Japan journal of cancer clinics.

[12]  M. Cruickshank.  Carcinoid Tumour of the Appendix , 1937, The Indian medical gazette.

[13]  R. Zirkin,et al.  Adenocarcinoid of appendix presenting as bilateral ovarian tumors. A case report with histochemical and ultrastructural studies. , 1980, Diagnostic gynecology and obstetrics.