The Role of Interleukin-6 in the Failing Heart

[1]  Qin M. Chen,et al.  Apoptosis and Heart Failure , 2002, American journal of cardiovascular drugs : drugs, devices, and other interventions.

[2]  S. Makino,et al.  Interleukin-6 Family of Cytokines Mediate Angiotensin II-induced Cardiac Hypertrophy in Rodent Cardiomyocytes* , 2000, The Journal of Biological Chemistry.

[3]  Y. Fujio,et al.  Isolation and characterization of the murine cardiotrophin-1 gene: expression and norepinephrine-induced transcriptional activation. , 2000, Journal of molecular and cellular cardiology.

[4]  P. Kang,et al.  Apoptosis and heart failure: A critical review of the literature. , 2000, Circulation research.

[5]  R. A. Hunt,et al.  Cardiotrophin-1 increases angiotensinogen mRNA in rat cardiac myocytes through STAT3 : an autocrine loop for hypertrophy. , 2000, Hypertension.

[6]  G. Freeman,et al.  beta-adrenergic blockade in developing heart failure: effects on myocardial inflammatory cytokines, nitric oxide, and remodeling. , 2000, Circulation.

[7]  G. Sanz,et al.  Prognostic value of serum cytokines in patients with congestive heart failure. , 2000, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[8]  M. Neurath,et al.  Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: Evidence in Crohn disease and experimental colitis in vivo , 2000, Nature Medicine.

[9]  H. Drexler,et al.  Expression of angiotensin II and interleukin 6 in human coronary atherosclerotic plaques: potential implications for inflammation and plaque instability. , 2000, Circulation.

[10]  S. Ogawa,et al.  Autocrine/Paracrine secretion of IL-6 family cytokines causes angiotensin II-induced delayed STAT3 activation. , 2000, Biochemical and biophysical research communications.

[11]  M. Kinoshita,et al.  Angiotensin II type 1 receptor antagonist decreases plasma levels of tumor necrosis factor alpha, interleukin-6 and soluble adhesion molecules in patients with chronic heart failure. , 2000, Journal of the American College of Cardiology.

[12]  M. Bristow.  β-Adrenergic Receptor Blockade in Chronic Heart Failure , 2000 .

[13]  H. Philippou,et al.  Relationships between homocysteine, factor VIIa, and thrombin generation in acute coronary syndromes. , 2000, Circulation.

[14]  M. Redfield,et al.  Augmented cardiac cardiotrophin-1 in experimental congestive heart failure. , 2000, Circulation.

[15]  M. Bristow.  b-Adrenergic Receptor Blockade in Chronic Heart Failure , 2000 .

[16]  S. Frøland,et al.  Effect of high- versus low-dose angiotensin converting enzyme inhibition on cytokine levels in chronic heart failure. , 1999, Journal of the American College of Cardiology.

[17]  J. Young.  Angiotensin-converting enzyme inhibitors and cytokines in heart failure: dose and effect? , 1999, Journal of the American College of Cardiology.

[18]  T. Boone,et al.  Novel neurotrophin-1/B cell-stimulating factor-3: a cytokine of the IL-6 family. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[19]  I. Masuda,et al.  Involvement of cardiotrophin-1 in cardiac myocyte-nonmyocyte interactions during hypertrophy of rat cardiac myocytes in vitro. , 1999, Circulation.

[20]  H. Drexler,et al.  The renin-angiotensin system and experimental heart failure. , 1999, Cardiovascular research.

[21]  J. Davies,et al.  An immunoluminometric assay for cardiotrophin-1: a newly identified cytokine is present in normal human plasma and is increased in heart failure. , 1999, Biochemical and biophysical research communications.

[22]  I. Masuda,et al.  A heart-specific increase in cardiotrophin-1 gene expression precedes the establishment of ventricular hypertrophy in genetically hypertensive rats. , 1999, Journal of hypertension.

[23]  J. Thornby,et al.  Natural variability of circulating levels of cytokines and cytokine receptors in patients with heart failure: implications for clinical trials. , 1999, Journal of the American College of Cardiology.

[24]  S. Ogawa,et al.  Mechanical stretch activates the JAK/STAT pathway in rat cardiomyocytes. , 1999, Circulation research.

[25]  J. Ross,et al.  Loss of a gp130 Cardiac Muscle Cell Survival Pathway Is a Critical Event in the Onset of Heart Failure during Biomechanical Stress , 1999, Cell.

[26]  M. Runge,et al.  Angiotensin II induces interleukin-6 transcription in vascular smooth muscle cells through pleiotropic activation of nuclear factor-kappa B transcription factors. , 1999, Circulation research.

[27]  M. Entman,et al.  Cardiac myocytes produce interleukin-6 in culture and in viable border zone of reperfused infarctions. , 1999, Circulation.

[28]  S. Frøland,et al.  Cytokine network in congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. , 1999, The American journal of cardiology.

[29]  P. Heinrich,et al.  Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. , 1998, The Biochemical journal.

[30]  Y. Fujio,et al.  Activation of gp130 transduces hypertrophic signals via STAT3 in cardiac myocytes. , 1998, Circulation.

[31]  A. Matsumori,et al.  Cytokine gene expression after myocardial infarction in rat hearts: possible implication in left ventricular remodeling. , 1998, Circulation.

[32]  A. Lin,et al.  Opposing Effects of Jun Kinase and p38 Mitogen-Activated Protein Kinases on Cardiomyocyte Hypertrophy , 1998, Molecular and Cellular Biology.

[33]  B. Brar,et al.  Cardiotrophin-1 induces heat shock protein accumulation in cultured cardiac cells and protects them from stressful stimuli. , 1998, Journal of molecular and cellular cardiology.

[34]  D. Fukai,et al.  Interleukin-6 spillover in the peripheral circulation increases with the severity of heart failure, and the high plasma level of interleukin-6 is an important prognostic predictor in patients with congestive heart failure. , 1998, Journal of the American College of Cardiology.

[35]  S. Ogawa,et al.  Leukemia inhibitory factor, a potent cardiac hypertrophic cytokine, activates the JAK/STAT pathway in rat cardiomyocytes. , 1997, Circulation research.

[36]  K. Chien,et al.  Cardiotrophin-1 and the role of gp130-dependent signaling pathways in cardiac growth and development , 1997, Journal of Molecular Medicine.

[37]  Y. Fujio,et al.  Signals through gp130 upregulate bcl-x gene expression via STAT1-binding cis-element in cardiac myocytes. , 1997, The Journal of clinical investigation.

[38]  E. Lakatta,et al.  Increased cardiomyocyte apoptosis during the transition to heart failure in the spontaneously hypertensive rat. , 1997, The American journal of physiology.

[39]  C A Beltrami,et al.  Apoptosis in the failing human heart. , 1997, The New England journal of medicine.

[40]  G. MacGowan,et al.  Circulating interleukin-6 in severe heart failure. , 1997, The American journal of cardiology.

[41]  K. Chien,et al.  Cardiotrophin 1 (CT-1) Inhibition of Cardiac Myocyte Apoptosis via a Mitogen-activated Protein Kinase-dependent Pathway , 1997, The Journal of Biological Chemistry.

[42]  Y. Fujio,et al.  Activation of JAK-STAT and MAP kinases by leukemia inhibitory factor through gp130 in cardiac myocytes. , 1996, Circulation.

[43]  John Calvin Reed,et al.  Programmed myocyte cell death affects the viable myocardium after infarction in rats. , 1996, Experimental cell research.

[44]  J. Heath,et al.  Cardiotrophin-1 Activates a Distinct Form of Cardiac Muscle Cell Hypertrophy , 1996, The Journal of Biological Chemistry.

[45]  H. Oral,et al.  Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: a report from the Studies of Left Ventricular Dysfunction (SOLVD). , 1996, Journal of the American College of Cardiology.

[46]  M. Munger,et al.  Circulating concentrations of proinflammatory cytokines in mild or moderate heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. , 1996, The American journal of cardiology.

[47]  E. Wolf,et al.  The function of the soluble interleukin 6 (IL-6) receptor in vivo: sensitization of human soluble IL-6 receptor transgenic mice towards IL- 6 and prolongation of the plasma half-life of IL-6 , 1996, The Journal of experimental medicine.

[48]  P. Heinrich,et al.  Purification and characterization of the soluble interleukin-6 receptor from human plasma and identification of an isoform generated through alternative splicing. , 1996, European journal of biochemistry.

[49]  D. Mann,et al.  Tumor Necrosis Factor-α and Tumor Necrosis Factor Receptors in the Failing Human Heart , 1996 .

[50]  R. Black,et al.  A metalloprotease inhibitor blocks shedding of the IL-6 receptor and the p60 TNF receptor. , 1995, Journal of immunology.

[51]  S. Akira,et al.  Interleukin-6 family of cytokines and gp130. , 1995, Blood.

[52]  T. Kishimoto,et al.  Continuous activation of gp130, a signal-transducing receptor component for interleukin 6-related cytokines, causes myocardial hypertrophy in mice. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[53]  W. Wood,et al.  Cardiotrophin-1 , 1995, The Journal of Biological Chemistry.

[54]  A. Ogata,et al.  Hypoxic stress induces cardiac myocyte-derived interleukin-6. , 1995, Circulation.

[55]  K. Chien,et al.  Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[56]  K. Matsumoto,et al.  Endothelin-induced interleukin-6 production by rat aortic endothelial cells. , 1995, Endocrinology.

[57]  G. Yancopoulos,et al.  Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130. , 1993, Blood.

[58]  M. Hibi,et al.  Molecular cloning of a murine IL-6 receptor-associated signal transducer, gp130, and its regulated expression in vivo. , 1992, Journal of immunology.

[59]  David A. Williams,et al.  Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[60]  H. Thoenen,et al.  Molecular cloning, expression and regional distribution of rat ciliary neurotrophic factor , 1989, Nature.

[61]  H. Marquardt,et al.  Molecular cloning, sequence analysis, and functional expression of a novel growth regulator, oncostatin M , 1989, Molecular and cellular biology.

[62]  T. Hirano,et al.  Bacterial lipopolysaccharide and inflammatory mediators augment IL-6 secretion by human endothelial cells. , 1989, Journal of immunology.

[63]  A. Kelso,et al.  Molecular cloning and expression of cDNA encoding a murine myeloid leukaemia inhibitory factor (LIF). , 1987, The EMBO journal.

[64]  T. Taniguchi,et al.  Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin , 1986, Nature.

[65]  T. Hirano,et al.  Purification to homogeneity and characterization of human B-cell differentiation factor (BCDF or BSFp-2). , 1985, Proceedings of the National Academy of Sciences of the United States of America.