论文信息 - Shannon Entropy and Fractal Analysis for the 16S Ribosomal RNA and COX2 mt-DNA Sequences in Primates Including Neanderthal

Shannon Entropy and Fractal Analysis for the 16S Ribosomal RNA and COX2 mt-DNA Sequences in Primates Including Neanderthal

The primate mt-DNA 16S rRNA and COX2 sequences, including Neanderthal sequences, were studied using nucleotide frequency, monoand di-nucleotide entropy, and fractal dimension. The fractal dimension was computed with the Higuchi method when a nucleotide sequence is expressed as a numerical sequence where each nucleotide is assigned its proton number. The results shows that the C+G percent correlates with the fractal dimension with R-square value of around 0.88 (N = 8) for both gene sequences. The Diand mono-nucleotide entropy is also well correlated with similar R-square values. For the COX2 gene, the human and Neanderthal cluster at high entropy suggests that chimp, gorilla, and orangutan were subjected to a higher selection pressure for this gene. The human COX2 has less entropy than the Neanderthal COX2 consistent with the presence of some selection pressure.

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