Modulation of human platelet adenylate cyclase by prostacyclin (PGX).

[1]  J. Vane,et al.  Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric and coeliac ateries and inhibits platelet aggregation. , 1976, Prostaglandins.

[2]  R. A. Johnson,et al.  The chemical structure of prostaglandin X (prostacyclin). , 1976, Prostaglandins.

[3]  J. Vane,et al.  Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides. , 1976, Prostaglandins.

[4]  J. Vane,et al.  An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation , 1976, Nature.

[5]  P. Needleman,et al.  Thromboxanes: selective biosynthesis and distinct biological properties. , 1976, Science.

[6]  M. Hamberg,et al.  Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxides , 1976, Nature.

[7]  M. Hamberg,et al.  Inhibition of basal and hormone-stimulated adenylate cyclase in adipocyte ghosts by the prostaglandin endoperoxide prostaglandin H2. , 1975, The Journal of biological chemistry.

[8]  B. Molony,et al.  Flurbiprofen, a new potent inhibitor of platelet aggregation , 1973 .

[9]  M. Hamberg,et al.  Detection and isolation of an endoperoxide intermediate in prostaglandin biosynthesis. , 1973, Proceedings of the National Academy of Sciences of the United States of America.

[10]  E. Salzman,et al.  Cyclic 3',5'-adenosine monophosphate in human blood platelets. II. Effect of N6-2'-o-dibutyryl cyclic 3',5'-adenosine monophosphate on platelet function. , 1971, The Journal of clinical investigation.

[11]  J. Smith,et al.  The influence on platelet aggregation of drugs that affect the accumulation of adenosine 3':5'-cyclic monophosphate in platelets. , 1971, The Biochemical journal.

[12]  G. Drummond,et al.  Adenyl cyclase in cardiac tissue. , 1970, The Journal of biological chemistry.

[13]  R. Hartmann,et al.  Divergent effects of epinephrine and prostaglandin E1 on the level of cyclic AMP in human blood platelets , 1969 .

[14]  A. O'toole,et al.  Cyclic guanosine 3',5'-monophosphate in mammalian tissues and urine. , 1969, The Journal of biological chemistry.

[15]  L. Birnbaumer,et al.  Glucagon-Sensitive Adenyl Cylase in Plasma Membrane of Hepatic Parenchymal Cells , 1969, Science.

[16]  M. Rodbell.  Metabolism of isolated fat cells. V. Preparation of "ghosts" and their properties; adenyl cyclase and other enzymes. , 1967, The Journal of biological chemistry.