Plasma protein biomarkers of ALI and ARDS

Proteomics provides abundant information on the relationships between biological molecules and disease mechanisms. We selected 507 signaling proteins in the bloodstream using antibody microarray technology to identify the difference in protein expression between acute lung injury/acute respiratory distress syndrome (ALI/ARDS) patients and healthy subjects. Biological analysis of the 507 proteins revealed systemic dysregulation of inflammation, immune responses and apoptosis in ARDS. Protein-protein networks that were involved in ALI/ARDS are described. The most important signaling pathways related to ALI/ARDS are cytokine-cytokine receptor interactions and chemokine signaling pathways. IL-23, glypican 3, and leptin R (receptor) might be potential predictors for ALI/ ARDS. This study identified novel potential biomarkers that might be involved in the inflammatory response, immune responses, and metabolism in ALI and ARDS.

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