SUPERFICIAL TUMOR HYPERTHERMIA WITH FLAT LEFT-HANDED METAMATERIAL LENS

Flat left-handed metamaterial (LHM) lens can generate appropriate focusing spot in biological tissue as required in microwave tumor hyperthermia treatment. By using single ∞at LHM lens to concentrate microwave in a mass of tissue covered by water bolus, microwave hyperthermia scheme is proposed for superflcial tumor hyperthermia. The power distribution in tissue is simulated by flnite- difierence time-domain method, and the thermal pattern is calculated by solving the bio-heat transfer equation. It is demonstrated that, by using a ∞at LHM lens of thickness of 4cm to concentrate microwave of 2.45GHz, a temperature above 42 - C can be achieved and maintained in one hour in a tissue region of about 1.0cm in width and 1.2cm in depth in tissue with the source amplitude of 43.44V/cm, which is suitable for superflcial tumor hyperthermia. By adjusting the position of microwave source, the heating zone in tissue can be adjusted in both the lateral and depth direction in tissue. The in∞uence of fat layer, efiects of water bolus and microwave frequency on hyperthermia, is investigated as well.

[1]  Gang Wang,et al.  Schemes of microwave hyperthermia by using flat left‐handed material lenses , 2009 .

[2]  Wang Gang,et al.  Focusing of a Flat Left-Handed Metamaterial Lens in a Heterogeneous and Lossy Medium , 2009 .

[3]  Gang Wang,et al.  Metamaterial lens applicator for microwave hyperthermia of breast cancer , 2009, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[4]  王刚,et al.  Focusing of a Flat Left-Handed Metamaterial Lens in a Heterogeneous and Lossy Medium , 2009 .

[5]  Jiang Zhu,et al.  Experimental verification of overcoming the diffraction limit with a volumetric Veselago-Pendry transmission-line lens. , 2008, Physical review letters.

[6]  A. Attari,et al.  STUDY OF WATER BOLUS EFFECT ON SAR PENETRATION DEPTH AND EFFECTIVE FIELD SIZE FOR LOCAL HYPERTHERMIA , 2008 .

[7]  Yu Gong,et al.  On the Size of Left-Handed Material Lens for Near-Field Target Detection by Focus Scanning , 2008 .

[8]  N.K. Uzunoglu,et al.  Enhancing the Focusing Properties of a Prototype Non-Invasive Brain Hyperthermia System: a Simulation Study , 2007, 2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[9]  K. Aydin,et al.  Subwavelength resolution with a negative-index metamaterial superlens , 2007 .

[10]  Yang Hao,et al.  Accurate modeling of the optical properties of left-handed media using a finite-difference time-domain method. , 2007, Physical review. E, Statistical, nonlinear, and soft matter physics.

[11]  Surya Pal Singh,et al.  ELLIPTICALLY BENT SLOTTED WAVEGUIDE CONFORMAL FOCUSED ARRAY FOR HYPERTHERMIA TREATMENT OF TUMORS IN CURVED REGION OF HUMAN BODY , 2006 .

[12]  T. Cui,et al.  Enhancement of specific absorption rate in lossy dielectric objects using a slab of left-handed material. , 2005, Physical review. E, Statistical, nonlinear, and soft matter physics.

[13]  Zeljko Vujaskovic,et al.  Randomized trial of hyperthermia and radiation for superficial tumors. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[14]  John B. Pendry,et al.  Refining the perfect lens , 2003 .

[15]  Paolo Bernardi,et al.  Specific absorption rate and temperature elevation in a subject exposed in the far-field of radio-frequency sources operating in the 10-900-MHz range , 2003, IEEE Transactions on Biomedical Engineering.

[16]  P R Stauffer,et al.  SAR pattern perturbations from resonance effects in water bolus layers used with superficial microwave hyperthermia applicators , 2002, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[17]  Svein K. Jacobsen,et al.  Dual-mode antenna design for microwave heating and noninvasive thermometry of superficial tissue disease , 2000, IEEE Transactions on Biomedical Engineering.

[18]  E. Gelvich,et al.  Resonance effects in applicator water boluses and their influence on SAR distribution patterns , 2000, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[19]  J. van der Zee,et al.  Comparison of the clinical effectiveness of the 433 MHz Lucite cone applicator with that of a conventional waveguide applicator in applications of superficial hyperthermia. , 1999, International journal of radiation oncology, biology, physics.

[20]  R J Myerson,et al.  Superficial hyperthermia and irradiation for recurrent breast carcinoma of the chest wall: prognostic factors in 196 tumors. , 1998, International journal of radiation oncology, biology, physics.

[21]  D. Kapp,et al.  Efficacy of adjuvant hyperthermia in the treatment of superficial recurrent breast cancer: confirmation and future directions. , 1996, International journal of radiation oncology, biology, physics.

[22]  D Machin,et al.  Radiotherapy with or without hyperthermia in the treatment of superficial localized breast cancer: results from five randomized controlled trials. International Collaborative Hyperthermia Group. , 1996, International journal of radiation oncology, biology, physics.

[23]  M.V. Prior,et al.  The use of a current sheet applicator array for superficial hyperthermia: incoherent versus coherent operation , 1995, IEEE Transactions on Biomedical Engineering.

[24]  F. Montecchia,et al.  Microstrip-antenna design for hyperthermia treatment of superficial tumors , 1992, IEEE Transactions on Biomedical Engineering.

[25]  H. H. Pennes Analysis of tissue and arterial blood temperatures in the resting human forearm. , 1948, Journal of applied physiology.