Global stability of a two-stage epidemic model with generalized non-linear incidence

A multi-stage model of disease transmission, which incorporates a generalized non-linear incidence function, is developed and analysed qualitatively. The model exhibits two steady states namely: a disease-free state and a unique endemic state. A global stability of the model reveals that the disease-free equilibrium is globally asymptotically stable (and therefore the disease can be eradicated) provided a certain threshold R0 (known as the basic reproductive number) is less than unity. On the other hand, the unique endemic equilibrium is globally asymptotically stable for R0 > 1.

[1]  S. Levin,et al.  Dynamical behavior of epidemiological models with nonlinear incidence rates , 1987, Journal of mathematical biology.

[2]  G. Serio,et al.  A generalization of the Kermack-McKendrick deterministic epidemic model☆ , 1978 .

[3]  S. Busenberg,et al.  Analysis of a disease transmission model in a population with varying size , 1990, Journal of mathematical biology.

[4]  B. Henderson-Sellers,et al.  Mathematics and Computers in Simulation , 1995 .

[5]  V. Capasso Mathematical Structures of Epidemic Systems , 1993, Lecture Notes in Biomathematics.

[6]  Herbert W. Hethcote,et al.  The Mathematics of Infectious Diseases , 2000, SIAM Rev..

[7]  Seyed M. Moghadas,et al.  Two core group models for sexual transmission of disease , 2002 .

[8]  Wolfgang Hahn,et al.  Stability of Motion , 1967 .

[9]  C. S. Holling,et al.  The functional response of predators to prey density and its role in mimicry and population regulation. , 1965 .

[10]  V. S. Ivlev,et al.  Experimental ecology of the feeding of fishes , 1962 .

[11]  Seyed M. Moghadas,et al.  Existence of limit cycles for predator–prey systems with a class of functional responses , 2001 .

[12]  Y. Hsieh,et al.  The effect of density-dependent treatment and behavior change on the dynamics of HIV transmission , 2001, Journal of mathematical biology.

[13]  A. J. Hall Infectious diseases of humans: R. M. Anderson & R. M. May. Oxford etc.: Oxford University Press, 1991. viii + 757 pp. Price £50. ISBN 0-19-854599-1 , 1992 .

[14]  Liancheng Wang,et al.  Global Dynamics of an SEIR Epidemic Model with Vertical Transmission , 2001, SIAM J. Appl. Math..

[15]  Y. Iwasa,et al.  Influence of nonlinear incidence rates upon the behavior of SIRS epidemiological models , 1986, Journal of Mathematical Biology.

[16]  O. Diekmann,et al.  On the definition and the computation of the basic reproduction ratio R0 in models for infectious diseases in heterogeneous populations , 1990, Journal of mathematical biology.

[17]  A. Pritchard,et al.  A control theoretic approach to containing the spread of rabies. , 2001, IMA journal of mathematics applied in medicine and biology.

[18]  J. Watmough,et al.  Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission. , 2002, Mathematical biosciences.