METHYL TESTOSTERONE ADMINISTERED ORALLY TO PATIENTS WITH MARKED TESTICULAR DEFICIENCY1

SEARCH for a potent testicular hormone has been rewarded with the discovery and development of testosterone and related androgenic steroids. The effectiveness of the various preparations of testosterone, administered by injection, by pellet implantation and by inunction has been attested by numerous observers (1, 2, 3). All methods of testosterone treatment have produced striking responses in various metabolic activities as well as in the sexual functions. However, testosterone and testosterone propionate are only slightly active when given by mouth. More recently the introduction of methyl testosterone for oral administration has produced encouraging results. This method gives promise of becoming a most acceptable form of treatment.