Monitoring enzyme reaction and screening of inhibitors of acetylcholinesterase by quantitative matrix-assisted laser desorption/ionization fourier transform mass spectrometry

[1]  Robert A Copeland,et al.  Evaluation of enzyme inhibitors in drug discovery. A guide for medicinal chemists and pharmacologists. , 2005, Methods of biochemical analysis.

[2]  Mei-Yi Zhang,et al.  Development of a liquid chromatography/tandem mass spectrometry method for the quantitation of acetylcholine and related neurotransmitters in brain microdialysis samples. , 2007, Journal of pharmaceutical and biomedical analysis.

[3]  J. Schwartz,et al.  Mixed inhibitors of angiotensin-converting enzyme (EC 3.4.15.1) and enkephalinase (EC 3.4.24.11): rational design, properties, and potential cardiovascular applications of glycopril and alatriopril. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[4]  P. Houghton,et al.  Natural Products and Derivatives Affecting Neurotransmission Relevant to Alzheimer’s and Parkinson’s Disease , 2005, Neurosignals.

[5]  Z. Rakonczay.  Potencies and Selectivities of Inhibitors of Acetylcholinesterase and Its Molecular Forms in Normal and Alzheimer’s Disease Brain , 2003, Acta biologica Hungarica.

[6]  J. Leary,et al.  Multiplex inhibitor screening and kinetic constant determinations for yeast hexokinase using mass spectrometry based assays , 2003, Journal of the American Society for Mass Spectrometry.

[7]  C. Costagli,et al.  Inhibition of cholinesterase-associated aryl acylamidase activity by anticholinesterase agents: focus on drugs potentially effective in Alzheimer's disease. , 1998, Biochemical pharmacology.

[8]  J. Mulzer,et al.  Synthesis and acetylcholinesterase inhibition of 5-desamino huperzine A derivatives. , 2001, Bioorganic & medicinal chemistry letters.

[9]  Joel L Sussman,et al.  The complex of a bivalent derivative of galanthamine with torpedo acetylcholinesterase displays drastic deformation of the active-site gorge: implications for structure-based drug design. , 2004, Journal of the American Chemical Society.

[10]  Arrin Katz,et al.  High throughput screening via mass spectrometry: a case study using acetylcholinesterase. , 2004, Assay and drug development technologies.

[11]  D. Jenden,et al.  Cerebral acetylcholine and choline contents and turnover following low-dose acetylcholinesterase inhibitors treatment in rats , 2006, Archives of Toxicology.

[12]  David C Schriemer,et al.  Micro-Scale Frontal Affinity Chromatography with Mass Spectrometric Detection: A New Method for the Screening of Compound Libraries. , 1998, Angewandte Chemie.

[13]  Paul V Attwood,et al.  Kinetics of an enzyme-catalyzed reaction measured by electrospray ionization mass spectrometry using a simple rapid mixing attachment. , 2004, Analytical biochemistry.

[14]  J. Reilly,et al.  Investigation of enzyme kinetics using quench-flow techniques with MALDI-TOF mass spectrometry. , 2000, Analytical chemistry.

[15]  Ulf Bömer,et al.  High‐Throughput Screening for Kinase Inhibitors , 2005, Chembiochem : a European journal of chemical biology.

[16]  D. Swaab,et al.  Alzheimer’s disease and NGF signaling , 2004, Journal of Neural Transmission.

[17]  Zhongmei Tang,et al.  Enzyme inhibitor screening by capillary electrophoresis with an on-column immobilized enzyme microreactor created by an ionic binding technique. , 2006, Analytical chemistry.

[18]  H. Irth,et al.  High-performance liquid chromatography-mass spectrometry-based acetylcholinesterase assay for the screening of inhibitors in natural extracts. , 2006, Journal of chromatography. A.

[19]  N S Gray,et al.  Discovery of estrogen sulfotransferase inhibitors from a purine library screen. , 2001, Journal of medicinal chemistry.

[20]  Vincenza Andrisano,et al.  Development and characterization of an immobilized enzyme reactor based on glyceraldehyde-3-phosphate dehydrogenase for on-line enzymatic studies , 2003 .

[21]  G. Siuzdak,et al.  Desorption/ionization on silicon (DIOS): A diverse mass spectrometry platform for protein characterization , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[22]  P. Imming,et al.  Drugs, their targets and the nature and number of drug targets , 2006, Nature Reviews Drug Discovery.

[23]  R. Kostiainen,et al.  Analysis of acetylcholine and choline in microdialysis samples by liquid chromatography/tandem mass spectrometry. , 2005, Rapid communications in mass spectrometry : RCM.

[24]  L. Johnson,et al.  Protein Kinase Inhibitors: Insights into Drug Design from Structure , 2004, Science.

[25]  S. Carr,et al.  Screening for high-affinity ligands to the Src SH2 domain using capillary isoelectric focusing-electrospray ionization ion trap mass spectrometry. , 1998, Analytical chemistry.

[26]  A. Alhomida,et al.  Sensitivity of bovine retinal acetylcholinesterase (E.C. 3.1.1.7) toward tacrine: Kinetic characterization , 1998, Journal of biochemical and molecular toxicology.

[27]  T. Letzel,et al.  Mass spectrometric real-time monitoring of enzymatic glycosidic hydrolysis, enzymatic inhibition and enzyme complexes , 2006, Analytical and bioanalytical chemistry.

[28]  U. Karst,et al.  Monitoring enzymatic conversions by mass spectrometry: a critical review , 2005, Analytical and bioanalytical chemistry.

[29]  P. Hurskainen,et al.  Novel detection strategies for drug discovery. , 2002, Drug discovery today.

[30]  C. Bertozzi,et al.  Kinetic analysis of NodST sulfotransferase using an electrospray ionization mass spectrometry assay. , 2002, Biochemistry.

[31]  G. Jiang,et al.  Monitoring enzyme reaction and screening enzyme inhibitor based on MALDI-TOF-MS platform with a matrix of oxidized carbon nanotubes , 2006, Journal of the American Society for Mass Spectrometry.

[32]  J. W. Finch,et al.  Comparison of desorption/ionization on silicon (DIOS) time-of-flight and liquid chromatography/tandem mass spectrometry for assaying enzyme-inhibition reactions. , 2004, Rapid Communications in Mass Spectrometry.

[33]  Mark Ellisman,et al.  A Mutation Linked with Autism Reveals a Common Mechanism of Endoplasmic Reticulum Retention for the α,β-Hydrolase Fold Protein Family* , 2006, Journal of Biological Chemistry.

[34]  K. Taylor.  Enzyme Kinetics and Mechanisms , 2002, Springer Netherlands.

[35]  H. Desaire,et al.  A strategy for the determination of enzyme kinetics using electrospray ionization with an ion trap mass spectrometer. , 2001, Analytical chemistry.

[36]  G. Siuzdak,et al.  Monitoring Enzyme Catalysis with Mass Spectrometry* , 2000, The Journal of Biological Chemistry.

[37]  S. Auriola,et al.  Quantitative determination of acetylcholine in microdialysis samples using liquid chromatography/atmospheric pressure spray ionization mass spectrometry. , 2007, Rapid communications in mass spectrometry : RCM.

[38]  M. Hows,et al.  High-performance liquid chromatography/tandem mass spectrometry assay for the rapid high sensitivity measurement of basal acetylcholine from microdialysates , 2002, Journal of Neuroscience Methods.

[39]  M. D. Leavell,et al.  Mass spectrometry and immobilized enzymes for the screening of inhibitor libraries. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[40]  K. Kawashima,et al.  Effects of physostigmine and calcium on acetylcholine efflux from the hippocampus of freely moving rats as determined by in vivo microdialysis and a radioimmunoassay , 2000, Neuroscience Letters.

[41]  K. Courtney,et al.  A new and rapid colorimetric determination of acetylcholinesterase activity. , 1961, Biochemical pharmacology.

[42]  Henk Lingeman,et al.  Mass spectrometry-based biochemical assays for enzyme-inhibitor screening , 2007 .

[43]  D. J. Burinsky,et al.  Detection of choline and acetylcholine in a pharmaceutical preparation using high-performance liquid chromatography/electrospray ionization mass spectrometry. , 2003, Journal of pharmaceutical and biomedical analysis.

[44]  Mark Ellisman,et al.  A mutation linked with autism reveals a common mechanism of endoplasmic reticulum retention for the alpha,beta-hydrolase fold protein family. , 2006, The Journal of biological chemistry.

[45]  M. Hämäläinen,et al.  Kinetic analysis of the interaction between HIV-1 protease and inhibitors using optical biosensor technology. , 2000, Analytical biochemistry.