Imatinib resistant BCR‐ABL1 mutations at relapse in children with Ph+ALL: a Children's Oncology Group (COG) study

the protocol. Acute mutiorgan failure is a common cause of death in adult sickle cell patients without Hepatitis-C (Perronne et al, 2002; Manci et al, 2003; Darbari et al, 2006). Cirrhosis with severe iron overload is often found on autopsy studies in adults with sickle cell disease. Close monitoring of the liver functions in patients on deferasirox is indicated. However, multiple studies have found that deferasirox protects against iron-induced hepatic injury as well as fulminant hepatitis (Al-Rousan et al, 2011; Deugnier et al, 2011; Sato et al, 2011). In summary, the acute multiorgan failure observed in this patient was secondary to the underlying sickle cell disease and the evidence does not indicate deferasirox as a causal agent.