A CASE OF CONSECUTIVE SEVERE NONHEMOLYTIC TRANSFUSION REACTION DUE TO IRRADIATED PLATELET CONCENTRATE: DOES ANTI-CERULOPLASMIN ANTIBODY PLAY AN IMPORTANT ROLE IN ADVERSE REACTIONS?

: Anti-ceruloplasmin antibody in patients is reported to potentially be involved in nonhemolytic transfusion reactions (NHTRs). A 65-year-old man suffering from myelodysplastic syndrome (MDS) exhibited successive severe (grade 3) anaphylactic transfusion reactions to platelet concentrate (PC). Although his ceruloplasmin levels were in the nor-mal range, antibodies against ceruloplasmin were detected. We considered anti-ceruloplasmin antibody to be a factors involved in the NHTRs, but the patient had never shown adverse responses due to RBC transfusions before or after these events of severe allergic reactions. We did not examine polymorphisms in his ceruloplasmin or subclasses of anti-ceruloplasmin antibody. We suspect the anti-ceruloplasmin antibody played little role in his anaphylactic transfusion reactions. Allergens proven to elicit allergic reactions are plasma proteins, such as IgA, haptoglobin, and comple-ment component 4 (C4); however, details of other mechanisms of allergic reaction are largely unknown. Further analysis will be required to avoid anaphylactic transfusion reactions in this patient, and we are going to use washed PC for future patients showing such allergic reactions.