Time domain echo pattern evaluations from normal and atherosclerotic arterial walls: a study in vitro.

The aim of this study in vitro of human fresh specimens was to quantitatively evaluate the contribution of the aqueous phase-intima interface (the first 400 msec of the reflected signal) in normal and atherosclerotic arterial walls. Seventy-five samples were studied, 15 normal, 15 fatty, 15 fibrofatty, 15 fibrous, and 15 calcific. A broadband transducer (4 to 14 MHz) was used. The aqueous phase-intima reflection (expressed in dB, mean +/- SD) was lowest in the fatty plaques (-35.3 +/- 2.5), differing in a highly significant way from that in all other groups: normal (-13.2 +/- 8.8), fibrofatty (-20.4 +/- 8.3), fibrous (-13.0 +/- 9.7), calcific (-5.9 +/- 3.4). The echo coming from the intima-media transition was of relatively low amplitude in normal and in fatty samples; typically, strong reflections from the intima-media transitions were present in the other pathologic subsets. In conclusion, the time domain echo pattern of the arterial wall may provide a useful clue to the structure of the plaque.

[1]  J. G. Miller,et al.  Quantitative ultrasonic characterization of the nature of atherosclerotic plaques in human aorta. , 1987, Circulation research.

[2]  L. Landini,et al.  The use of frequency histograms of ultrasonic backscatter amplitudes for detection of atherosclerosis in vitro. , 1986, Circulation.

[3]  L Landini,et al.  Evaluation of frequency dependence of backscatter coefficient in normal and atherosclerotic aortic walls. , 1986, Ultrasound in medicine & biology.

[4]  J. Hestenes,et al.  The Use of Ultrasonic Spectroscopy to Characterize Calcified Lesions , 1981, IEEE Transactions on Sonics and Ultrasonics.

[5]  K. Shung,et al.  Further studies on acoustic impedance of major bovine blood vessel walls. , 1982, The Journal of the Acoustical Society of America.

[6]  L Landini,et al.  Fibrosis, Lipids, and Calcium in Human Atherosclerotic Plaque In Vitro Differentiation from Normal Aortic Walls by Ultrasonic Attenuation , 1985, Circulation research.

[7]  J. G. Miller,et al.  Ultrasonic characterization of myocardium. , 1985, Progress in cardiovascular diseases.

[8]  D. Strandness,et al.  The effects of atherosclerosis on the transmission of ultrasound. , 1969, The Journal of surgical research.

[9]  Luigi Landini,et al.  Different degrees of atherosclerosis detected by backscattered ultrasound: An in vitro study on fixed human aortic walls , 1983, Journal of clinical ultrasound : JCU.

[10]  M. Bond,et al.  Physicochemical and histological changes in the arterial wall of nonhuman primates during progression and regression of atherosclerosis. , 1984, The Journal of clinical investigation.

[11]  D H Blankenhorn,et al.  Velocity and attenuation of sound in arterial tissues. , 1982, The Journal of the Acoustical Society of America.

[12]  R. Kerber,et al.  High frequency epicardial echocardiography for coronary artery evaluation: in vitro and in vivo validation of arterial lumen and wall thickness measurements. , 1986, Journal of the American College of Cardiology.

[13]  P Pignoli,et al.  Intimal plus medial thickness of the arterial wall: a direct measurement with ultrasound imaging. , 1986, Circulation.

[14]  James F. Greenleaf,et al.  Ultrasonic Data Acquisition and Processing System for Atherosclerotic Tissue Characterization , 1974 .