Advances on Liquid Biopsy Analysis for Glioma Diagnosis
暂无分享,去创建一个
[1] A. Gargalionis,et al. Exosomes as Novel Diagnostic Biomarkers and Therapeutic Tools in Gliomas , 2023, International journal of molecular sciences.
[2] A. A. Modestov,et al. Development of DNA aptamers for visualization of glial brain tumors and detection of circulating tumor cells. , 2023, Molecular therapy. Nucleic acids.
[3] R. Schilsky,et al. Closing the Gap in Cancer Genomic Testing. , 2022, The New England journal of medicine.
[4] A. Aibaidula,et al. Strategies, considerations, and recent advancements in the development of liquid biopsy for glioblastoma: a step towards individualized medicine in glioblastoma. , 2022, Neurosurgical focus.
[5] J. Phallen,et al. Advances in molecular biomarkers and liquid biopsy in gliomas , 2022, Neuro-oncology advances.
[6] E. Carpenter,et al. Clinical utility of plasma cell-free DNA in gliomas , 2022, Neuro-oncology advances.
[7] N. Husain,et al. Dynamics of cell-free DNA in predicting response in adult diffuse glioma on chemoradiotherapy. , 2022, Cancer genetics.
[8] A. Coosemans,et al. Liquid Biopsy in Glioblastoma , 2022, Cancers.
[9] S. Bennis,et al. Molecular and Circulating Biomarkers in Patients with Glioblastoma , 2022, International journal of molecular sciences.
[10] Tariq Ahmad Masoodi,et al. Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatments , 2022, Molecular Cancer.
[11] Reeshan ul Quraish,et al. Liquid Biopsy: A Distinctive Approach to the Diagnosis and Prognosis of Cancer , 2022, Cancer informatics.
[12] F. Mouliere,et al. Cell-free DNA technologies for the analysis of brain cancer , 2021, British Journal of Cancer.
[13] M. Schneemann,et al. Liquid Biopsy and Primary Brain Tumors , 2021, Cancers.
[14] G. Reifenberger,et al. The 2021 WHO Classification of Tumors of the Central Nervous System: a summary. , 2021, Neuro-oncology.
[15] B. Mroczko,et al. Molecular and Circulating Biomarkers of Brain Tumors , 2021, International journal of molecular sciences.
[16] A. Brandes,et al. Liquid biopsy in gliobastoma management: from current research to future perspectives. , 2021, The oncologist.
[17] N. Klopov,et al. Evaluation of Haptoglobin and Its Proteoforms as Glioblastoma Markers , 2021, International journal of molecular sciences.
[18] G. Lippi,et al. Serum Exosomal microRNA-21, 222 and 124-3p as Noninvasive Predictive Biomarkers in Newly Diagnosed High-Grade Gliomas: A Prospective Study , 2021, Cancers.
[19] Minming Zhang,et al. Exploring MRI Characteristics of Brain Diffuse Midline Gliomas With the H3 K27M Mutation Using Radiomics , 2021, Frontiers in Oncology.
[20] C. Maher,et al. Long noncoding RNAs in cancer metastasis , 2021, Nature Reviews Cancer.
[21] Sidong Liu,et al. Machine Learning for the Prediction of Molecular Markers in Glioma on Magnetic Resonance Imaging: A Systematic Review and Meta-Analysis , 2021, Neurosurgery.
[22] P. Lambin,et al. Development and external validation of a non-invasive molecular status predictor of chromosome 1p/19q co-deletion based on MRI radiomics analysis of Low Grade Glioma patients. , 2021, European journal of radiology.
[23] F. Yin,et al. Radiogenomic Analysis of Locally Advanced Lung Cancer Based on CT Imaging and Intratreatment Changes in Cell-Free DNA. , 2021, Radiology. Imaging cancer.
[24] S. Mueller,et al. Standardization of the liquid biopsy for pediatric diffuse midline glioma using ddPCR , 2021, Scientific Reports.
[25] Zhangsuo Liu,et al. Identification of low-dose radiation-induced exosomal circ-METRN and miR-4709-3p/GRB14/PDGFRα pathway as a key regulatory mechanism in Glioblastoma progression and radioresistance: Functional validation and clinical theranostic significance , 2021, International journal of biological sciences.
[26] A. Papavassiliou,et al. Prominent Role of Histone Modifications in the Regulation of Tumor Metastasis , 2021, International journal of molecular sciences.
[27] T. Mikkelsen,et al. A serum-based DNA methylation assay provides accurate detection of glioma. , 2021, Neuro-oncology.
[28] M. Frenkel-Morgenstern,et al. Detection of gene mutations and gene–gene fusions in circulating cell‐free DNA of glioblastoma patients: an avenue for clinically relevant diagnostic analysis , 2021, Molecular oncology.
[29] R. Jain,et al. Radiogenomics identifying important biological pathways in gliomas. , 2021, Neuro-oncology.
[30] Xi Yang,et al. The Era of Radiogenomics in Precision Medicine: An Emerging Approach to Support Diagnosis, Treatment Decisions, and Prognostication in Oncology , 2021, Frontiers in Oncology.
[31] A. Morokoff,et al. Circulating Biomarkers for Glioma: A Review. , 2021, Neurosurgery.
[32] T. Iwaki,et al. Molecular diagnosis of diffuse glioma using a chip-based digital PCR system to analyze IDH, TERT, and H3 mutations in the cerebrospinal fluid , 2021, Journal of Neuro-Oncology.
[33] Minghon Lu. Circular RNA: functions, applications and prospects , 2020, ExRNA.
[34] Chendan Jiang,et al. Thin-Slice Magnetic Resonance Imaging-Based Radiomics Signature Predicts Chromosomal 1p/19q Co-deletion Status in Grade II and III Gliomas , 2020, Frontiers in Neurology.
[35] P. Netti,et al. Exosomes in Gliomas: Biogenesis, Isolation, and Preliminary Applications in Nanomedicine , 2020, Pharmaceuticals.
[36] C. Coch,et al. Analysis of Serum miRNA in Glioblastoma Patients: CD44-Based Enrichment of Extracellular Vesicles Enhances Specificity for the Prognostic Signature , 2020, International journal of molecular sciences.
[37] Hakho Lee,et al. TERT Promoter Mutation Analysis for Blood-Based Diagnosis and Monitoring of Gliomas , 2020, Clinical Cancer Research.
[38] M. Szilágyi,et al. Circulating Cell-Free Nucleic Acids: Main Characteristics and Clinical Application , 2020, International journal of molecular sciences.
[39] Weiqin Li,et al. Exosome-Mediated Transfer of Long Noncoding RNA HOTAIR Regulates Temozolomide Resistance by miR-519a-3p/RRM1 Axis in Glioblastoma. , 2020, Cancer biotherapy & radiopharmaceuticals.
[40] E. Calabrese,et al. A fully automated artificial intelligence method for non-invasive, imaging-based identification of genetic alterations in glioblastomas , 2020, Scientific Reports.
[41] Jitender Saini,et al. A Review of Radiomics and Deep Predictive Modeling in Glioma Characterization. , 2020, Academic radiology.
[42] A. Kopylov,et al. Proteome of Glioblastoma-Derived Exosomes as a Source of Biomarkers , 2020, Biomedicines.
[43] K. Aldape,et al. Detection and discrimination of intracranial tumors using plasma cell-free DNA methylomes , 2020, Nature Medicine.
[44] Guangyao Wu,et al. Noninvasive Prediction of TERT Promoter Mutations in High-Grade Glioma by Radiomics Analysis Based on Multiparameter MRI , 2020, BioMed research international.
[45] T. Roberts,et al. Isolation of Circulating Tumor Cells from Glioblastoma Patients by Direct Immunomagnetic Targeting , 2020, Applied Sciences.
[46] Seigo Nakamura,et al. Liquid biopsy for the detection of clinical biomarkers in early breast cancer: new insights and challenges. , 2020, Pharmacogenomics.
[47] H. Yoon,et al. Comparison of Four Commercial Kits for Isolation of Urinary Cell-Free DNA and Sample Storage Conditions , 2020, Diagnostics.
[48] Raghu Kalluri,et al. The biology, function, and biomedical applications of exosomes , 2020, Science.
[49] S. Stylli,et al. Extracellular vesicles and their role in glioblastoma , 2019, Critical reviews in clinical laboratory sciences.
[50] Hongyu Zhao,et al. Next-generation sequencing in liquid biopsy: cancer screening and early detection , 2019, Human Genomics.
[51] Shusheng Zhang,et al. Preparation of a Novel Raman Probe and its Application in the Detection of Circulating Tumor Cells and Exosomes. , 2019, ACS applied materials & interfaces.
[52] A. Klekner,et al. Significance of liquid biopsy in glioblastoma - A review. , 2019, Journal of biotechnology.
[53] V. Taly,et al. Liquid Biopsy: General Concepts , 2019, Acta Cytologica.
[54] L. Sedger,et al. Intercellular Vesicular Transfer by Exosomes, Microparticles and Oncosomes - Implications for Cancer Biology and Treatments , 2019, Front. Oncol..
[55] S. Holdenrieder,et al. The emerging role of cell-free DNA as a molecular marker for cancer management , 2019, Biomolecular detection and quantification.
[56] G. Reifenberger,et al. The lncRNA TP73-AS1 is linked to aggressiveness in glioblastoma and promotes temozolomide resistance in glioblastoma cancer stem cells , 2019, Cell Death & Disease.
[57] Peiyong Jiang,et al. Orientation-aware plasma cell-free DNA fragmentation analysis in open chromatin regions informs tissue of origin , 2019, Genome research.
[58] Tessandra H Stewart,et al. New windows into the brain: Central nervous system-derived extracellular vesicles in blood , 2019, Progress in Neurobiology.
[59] Zhi Zhu,et al. Bioinspired Engineering of a Multivalent Aptamer-Functionalized Nanointerface to Enhance the Capture and Release of Circulating Tumor Cells. , 2018, Angewandte Chemie.
[60] Keval Patel,et al. Enhanced detection of circulating tumor DNA by fragment size analysis , 2018, Science Translational Medicine.
[61] N. Rosenfeld,et al. Detection of cell‐free DNA fragmentation and copy number alterations in cerebrospinal fluid from glioma patients , 2018, EMBO molecular medicine.
[62] Y. You,et al. Exosomal transfer of miR-151a enhances chemosensitivity to temozolomide in drug-resistant glioblastoma. , 2018, Cancer letters.
[63] Winnie S. Liang,et al. Clinically Relevant and Minimally Invasive Tumor Surveillance of Pediatric Diffuse Midline Gliomas Using Patient-Derived Liquid Biopsy , 2018, Clinical Cancer Research.
[64] Long Wang,et al. New method to preserve the original proportion and integrity of urinary cell‐free DNA , 2018, Journal of clinical laboratory analysis.
[65] N. Butowski,et al. Primary brain tumours in adults , 2018, The Lancet.
[66] Abel J Bronkhorst,et al. The diverse origins of circulating cell‐free DNA in the human body: a critical re‐evaluation of the literature , 2018, Biological reviews of the Cambridge Philosophical Society.
[67] R. Plummer,et al. Detection of circulating tumour cell clusters in human glioblastoma , 2018, British Journal of Cancer.
[68] Gladys N. Nangami,et al. Impact of Fetuin-A (AHSG) on Tumor Progression and Type 2 Diabetes , 2018, International journal of molecular sciences.
[69] H. Jung,et al. Salivary Exosome and Cell-Free DNA for Cancer Detection , 2018, Micromachines.
[70] R. Kimmig,et al. RNA Profiles of Circulating Tumor Cells and Extracellular Vesicles for Therapy Stratification of Metastatic Breast Cancer Patients. , 2018, Clinical chemistry.
[71] T. Quirico-Santos,et al. Circulating Cell-Free DNA as a Prognostic and Molecular Marker for Patients with Brain Tumors under Perillyl Alcohol-Based Therapy , 2018, International journal of molecular sciences.
[72] N. López-Bigas,et al. Molecular Diagnosis of Diffuse Gliomas through Sequencing of Cell-Free Circulating Tumor DNA from Cerebrospinal Fluid , 2018, Clinical Cancer Research.
[73] G. Pfeifer. Defining Driver DNA Methylation Changes in Human Cancer , 2018, International journal of molecular sciences.
[74] T. Terasaki,et al. Identification of blood biomarkers in glioblastoma by SWATH mass spectrometry and quantitative targeted absolute proteomics , 2018, PloS one.
[75] Lili Sun,et al. Antitumor effect of the Newcastle disease viral hemagglutinin–neuraminidase gene is expressed through an oncolytic adenovirus effect in osteosarcoma cells , 2018, Anti-cancer drugs.
[76] Ludmila V. Danilova,et al. Detection and localization of surgically resectable cancers with a multi-analyte blood test , 2018, Science.
[77] Kai Huang,et al. The role of PTRF/Cavin1 as a biomarker in both glioma and serum exosomes , 2018, Theranostics.
[78] T. Jiang,et al. Genotype prediction of ATRX mutation in lower-grade gliomas using an MRI radiomics signature , 2018, European Radiology.
[79] Q. Pan,et al. Serum exosomal miR-301a as a potential diagnostic and prognostic biomarker for human glioma , 2018, Cellular Oncology.
[80] G. Calin,et al. Serum HOTAIR and GAS5 levels as predictors of survival in patients with glioblastoma , 2018, Molecular carcinogenesis.
[81] L. Sobrevia,et al. Role of extracellular vesicles in glioma progression. , 2017, Molecular aspects of medicine.
[82] C. Bettegowda,et al. Detection of wild-type EGFR amplification and EGFRvIII mutation in CSF-derived extracellular vesicles of glioblastoma patients , 2017, Neuro-oncology.
[83] R. Lyle,et al. A comprehensive profile of circulating RNAs in human serum , 2017, bioRxiv.
[84] A. Bhan,et al. Long Noncoding RNA and Cancer: A New Paradigm. , 2017, Cancer research.
[85] Gang Qin,et al. Prognostic Value of YKL-40 in Patients with Glioblastoma: a Systematic Review and Meta-analysis , 2017, Molecular Neurobiology.
[86] Y. Marie,et al. Same-day genomic and epigenomic diagnosis of brain tumors using real-time nanopore sequencing , 2017, Acta Neuropathologica.
[87] Michael R. Speicher,et al. Emerging concepts in liquid biopsies , 2017, BMC Medicine.
[88] S. Stylli,et al. The emergent role of exosomes in glioma , 2017, Journal of Clinical Neuroscience.
[89] R. Christopherson,et al. Comprehensive proteome profiling of glioblastoma-derived extracellular vesicles identifies markers for more aggressive disease , 2016, Journal of Neuro-Oncology.
[90] L. Hui,et al. Evaluation and comparison of in vitro degradation kinetics of DNA in serum, urine and saliva: A qualitative study. , 2016, Gene.
[91] Haihui Jiang,et al. Circulating tumor cell is a common property of brain glioma and promotes the monitoring system , 2016, Oncotarget.
[92] G. Piaggio,et al. A restricted signature of serum miRNAs distinguishes glioblastoma from lower grade gliomas , 2016, Journal of experimental & clinical cancer research : CR.
[93] Stefanie Dimmeler,et al. Long Noncoding RNAs: From Clinical Genetics to Therapeutic Targets? , 2016, Journal of the American College of Cardiology.
[94] J. Massagué,et al. Metastatic colonization by circulating tumour cells , 2016, Nature.
[95] Manfred Westphal,et al. Circulating biomarkers for gliomas , 2015, Nature Reviews Neurology.
[96] Kristie L. Rose,et al. Proteomics characterization of exosome cargo. , 2015, Methods.
[97] S. Marsigliante,et al. miR-15b and miR-21 as Circulating Biomarkers for Diagnosis of Glioma , 2015, Current genomics.
[98] T. Rajkumar,et al. Role of Circulating Cell-Free DNA in Cancers , 2015, Molecular Diagnosis & Therapy.
[99] T. Jiang,et al. Exosomal levels of miRNA-21 from cerebrospinal fluids associated with poor prognosis and tumor recurrence of glioma patients , 2015, Oncotarget.
[100] J. Ptak,et al. Detection of tumor-derived DNA in cerebrospinal fluid of patients with primary tumors of the brain and spinal cord , 2015, Proceedings of the National Academy of Sciences.
[101] P. Laktionov,et al. Extracellular Nucleic Acids in Urine: Sources, Structure, Diagnostic Potential , 2015, Acta naturae.
[102] J. Meldolesi,et al. Ectosomes and exosomes: shedding the confusion between extracellular vesicles. , 2015, Trends in cell biology.
[103] Bob S. Carter,et al. Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma , 2015, Nature Communications.
[104] Claudia Mongini,et al. Emerging Roles of Exosomes in Normal and Pathological Conditions: New Insights for Diagnosis and Therapeutic Applications , 2015, Front. Immunol..
[105] I. Nakano,et al. miRNA contents of cerebrospinal fluid extracellular vesicles in glioblastoma patients , 2015, Journal of Neuro-Oncology.
[106] Q. Lan,et al. Identification of 9 serum microRNAs as potential noninvasive biomarkers of human astrocytoma. , 2015, Neuro-oncology.
[107] K. Hoang-Xuan,et al. Diagnostic and prognostic value of preoperative combined GFAP, IGFBP‐2, and YKL‐40 plasma levels in patients with glioblastoma , 2014, Cancer.
[108] A. Iafrate,et al. Brain tumor cells in circulation are enriched for mesenchymal gene expression. , 2014, Cancer discovery.
[109] Lun Dong,et al. miRNA microarray reveals specific expression in the peripheral blood of glioblastoma patients. , 2014, International journal of oncology.
[110] J. Erler,et al. Brain Cancer Spreads , 2014, Science Translational Medicine.
[111] M. Speicher,et al. Hematogenous dissemination of glioblastoma multiforme , 2014, Science Translational Medicine.
[112] C. Chapman,et al. Detection of brain tumor cells in the peripheral blood by a telomerase promoter-based assay. , 2014, Cancer research.
[113] H. Newton,et al. Hypofractionated intensity modulated radiotherapy with temozolomide in newly diagnosed glioblastoma multiforme , 2014, Journal of Clinical Neuroscience.
[114] M. Choti,et al. Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies , 2014, Science Translational Medicine.
[115] E. Rizzarelli,et al. Carnosinases, Their Substrates and Diseases , 2014, Molecules.
[116] J. Villano,et al. Long-term treatment with temozolomide in malignant glioma , 2014, Journal of Clinical Neuroscience.
[117] Amaia Agirre,et al. A small noncoding RNA signature found in exosomes of GBM patient serum as a diagnostic tool. , 2014, Neuro-oncology.
[118] L. Gong,et al. MicroRNA-21 expression is associated with overall survival in patients with glioma , 2013, Diagnostic Pathology.
[119] N. Kosaka,et al. A paradigm shift for extracellular vesicles as small RNA carriers: from cellular waste elimination to therapeutic applications , 2013, Drug Delivery and Translational Research.
[120] Katrin J. Svensson,et al. Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity , 2013, Proceedings of the National Academy of Sciences.
[121] M. Ringnér,et al. Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development , 2013, Proceedings of the National Academy of Sciences.
[122] Sadik C. Esener,et al. Isolation of Rare Tumor Cells from Blood Cells with Buoyant Immuno-Microbubbles , 2013, PloS one.
[123] Qiong Wang,et al. Plasma specific miRNAs as predictive biomarkers for diagnosis and prognosis of glioma , 2012, Journal of experimental & clinical cancer research : CR.
[124] Hakho Lee,et al. Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy , 2012, Nature Medicine.
[125] Y. Marie,et al. Detection of IDH1 mutation in the plasma of patients with glioma , 2012, Neurology.
[126] Ravi Sirdeshmukh,et al. Proteins with Altered Levels in Plasma from Glioblastoma Patients as Revealed by iTRAQ-Based Quantitative Proteomic Analysis , 2012, PloS one.
[127] C. Marosi,et al. Plasma MicroRNA-21 Concentration May Be a Useful Biomarker in Glioblastoma Patients , 2012, Cancer investigation.
[128] J. Silke,et al. The Tumor Suppressor PTEN Is Exported in Exosomes and Has Phosphatase Activity in Recipient Cells , 2012, Science Signaling.
[129] David G. Knowles,et al. The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression , 2012, Genome research.
[130] Lei Han,et al. High level of miR-221/222 confers increased cell invasion and poor prognosis in glioma , 2012, Journal of Translational Medicine.
[131] W. Moon,et al. Imaging parameters of high grade gliomas in relation to the MGMT promoter methylation status: the CT, diffusion tensor imaging, and perfusion MR imaging , 2012, Neuroradiology.
[132] K. Pantel,et al. Circulating epithelial cells in patients with benign colon diseases. , 2012, Clinical chemistry.
[133] V. Vlassov,et al. Cell-free and cell-bound circulating nucleic acid complexes: mechanisms of generation, concentration and content , 2012, Expert opinion on biological therapy.
[134] M. Esteller. Non-coding RNAs in human disease , 2011, Nature Reviews Genetics.
[135] P. Febbo,et al. NCCN Task Force report: Evaluating the clinical utility of tumor markers in oncology. , 2011, Journal of the National Comprehensive Cancer Network : JNCCN.
[136] J. Mattick,et al. Somatic retrotransposition alters the genetic landscape of the human brain , 2011, Nature.
[137] A Mukherjee,et al. Nucleic acid aptamers: clinical applications and promising new horizons. , 2011, Current medicinal chemistry.
[138] Y. Kondo,et al. The Global DNA Methylation Surrogate LINE-1 Methylation Is Correlated with MGMT Promoter Methylation and Is a Better Prognostic Factor for Glioma , 2011, PloS one.
[139] C. Théry. Exosomes: secreted vesicles and intercellular communications , 2011, F1000 biology reports.
[140] Susan M. Chang,et al. DNA hypermethylation profiles associated with glioma subtypes and EZH2 and IGFBP2 mRNA expression. , 2011, Neuro-oncology.
[141] Brigitte Rack,et al. Apoptosis-related deregulation of proteolytic activities and high serum levels of circulating nucleosomes and DNA in blood correlate with breast cancer progression , 2011, BMC Cancer.
[142] T. Siegal,et al. Serum DNA can define tumor-specific genetic and epigenetic markers in gliomas of various grades. , 2010, Neuro-oncology.
[143] Gene W. Yeo,et al. L1 retrotransposition in human neural progenitor cells , 2009, Nature.
[144] Johan Skog,et al. Glioblastoma microvesicles transport RNA and protein that promote tumor growth and provide diagnostic biomarkers , 2008, Nature Cell Biology.
[145] M. Sanz-Casla,et al. Circulating tumor cells in colorectal cancer: correlation with clinical and pathological variables. , 2008, Annals of oncology : official journal of the European Society for Medical Oncology.
[146] D. Demetrick,et al. The Use of Magnetic Resonance Imaging to Noninvasively Detect Genetic Signatures in Oligodendroglioma , 2008, Clinical Cancer Research.
[147] F. Oppenheim,et al. Saliva: a Dynamic Proteome , 2007, Journal of dental research.
[148] L. Zitvogel,et al. Exosome-based immunotherapy , 2004, Cancer Immunology, Immunotherapy.
[149] Y. Roussos,et al. O6-methyl-guanine-DNA methyltransferase methylation in serum and tumor DNA predicts response to 1,3-bis(2-chloroethyl)-1-nitrosourea but not to temozolamide plus cisplatin in glioblastoma multiforme. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.
[150] L. Zitvogel,et al. Tumor-derived exosomes: a new source of tumor rejection antigens. , 2002, Vaccine.
[151] R. Bast,et al. Tumor marker utility grading system: a framework to evaluate clinical utility of tumor markers. , 1996, Journal of the National Cancer Institute.
[152] T. Yasuda,et al. Measurement of deoxyribonuclease I activity in human tissues and body fluids by a single radial enzyme-diffusion method. , 1993, Clinical chemistry.
[153] OUP accepted manuscript , 2022, Neuro-Oncology.
[154] Qiong Wang,et al. Downregulation of serum microRNA-205 as a potential diagnostic and prognostic biomarker for human glioma. , 2016, Journal of neurosurgery.
[155] International Human Genome Sequencing Consortium. Initial sequencing and analysis of the human genome , 2001, Nature.
[156] A. Chávez-Reyes,et al. International Journal of Molecular Sciences Exosomes: from Garbage Bins to Promising Therapeutic Targets , 2022 .