Early development of subcortical regions involved in non-cued attention switching.

This study examined the cognitive and neural development of attention switching using a simple forced-choice attention task and functional magnetic resonance imaging Fourteen children and adults made discriminations among stimuli based on either shape or color. Performance on these trials was compared to performance during blocked trials requiring all color or all shape discriminations. Magnetic resonance echo planar images were acquired during performance of the task. Both children and adults showed robust bilateral activity of the caudate nucleus when switching attention between color and shape discriminations that correlated negatively with mean response latency on these trials. However, neither switching costs nor caudate activity correlated with age, suggesting early development of the underlying neural circuitry involved in switching between salient stimulus sets. Overall, children and adults differed in performance and patterns of brain activity on the task, with adults responding more accurately and faster than children, and recruiting more prefrontal and parietal regions. These results suggest an important role of subcortical regions (i.e. caudate nucleus) in non-cued attention switching, with increasing recruitment of cortical regions with age.

[1]  A. Kramer,et al.  Changes in executive control across the life span: examination of task-switching performance. , 2001, Developmental psychology.

[2]  Toshio Inui,et al.  The role of the posterior parietal cortex in human object recognition: a functional magnetic resonance imaging study , 1999, Neuroscience Letters.

[3]  E. Crone,et al.  Dissociation of response conflict, attentional selection, and expectancy with functional magnetic resonance imaging. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[4]  Suzanne E. Welcome,et al.  Mapping cortical change across the human life span , 2003, Nature Neuroscience.

[5]  B. J. Casey,et al.  Clinical, imaging, lesion, and genetic approaches toward a model of cognitive control. , 2002, Developmental psychobiology.

[6]  Jonathan D. Cohen,et al.  Computational perspectives on dopamine function in prefrontal cortex , 2002, Current Opinion in Neurobiology.

[7]  Y. Munakata,et al.  All Together Now: When Dissociations Between Knowledge and Action Disappear , 2001, Psychological science.

[8]  S. Keele,et al.  Toward a Functional Analysis of the Basal Ganglia , 1998, Journal of Cognitive Neuroscience.

[9]  Jonathan D. Cohen,et al.  Improved Assessment of Significant Activation in Functional Magnetic Resonance Imaging (fMRI): Use of a Cluster‐Size Threshold , 1995, Magnetic resonance in medicine.

[10]  T. Robbins,et al.  Enhanced or impaired cognitive function in Parkinson's disease as a function of dopaminergic medication and task demands. , 2001, Cerebral cortex.

[11]  M. Botvinick,et al.  Anterior cingulate cortex, error detection, and the online monitoring of performance. , 1998, Science.

[12]  M. L. Howe,et al.  Emerging Themes in Cognitive Development , 1993, Springer New York.

[13]  A. Treisman,et al.  A feature-integration theory of attention , 1980, Cognitive Psychology.

[14]  N. Cohen,et al.  Prefrontal regions play a predominant role in imposing an attentional 'set': evidence from fMRI. , 2000, Brain research. Cognitive brain research.

[15]  R. Desimone,et al.  Neural mechanisms of selective visual attention. , 1995, Annual review of neuroscience.

[16]  J. Mink.  THE BASAL GANGLIA: FOCUSED SELECTION AND INHIBITION OF COMPETING MOTOR PROGRAMS , 1996, Progress in Neurobiology.

[17]  Scott P. Johnson,et al.  Visual statistical learning in infancy: evidence for a domain general learning mechanism , 2002, Cognition.

[18]  N. Cohen,et al.  General and task-specific frontal lobe recruitment in older adults during executive processes: A fMRI investigation of task-switching , 2001, Neuroreport.

[19]  P. Redgrave,et al.  The basal ganglia: a vertebrate solution to the selection problem? , 1999, Neuroscience.

[20]  D. A. Taylor,et al.  The cuing and priming of cognitive operations. , 1987, Journal of experimental psychology. Human perception and performance.

[21]  G H Glover,et al.  Selective effects of methylphenidate in attention deficit hyperactivity disorder: a functional magnetic resonance study. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[22]  B. J. Casey,et al.  Implication of right frontostriatal circuitry in response inhibition and attention-deficit/hyperactivity disorder. , 1997, Journal of the American Academy of Child and Adolescent Psychiatry.

[23]  B. J. Casey,et al.  Evidence for a mechanistic model of cognitive control , 2001, Clinical Neuroscience Research.

[24]  M. Schmitter-Edgecombe,et al.  Costs of a predictable switch between simple cognitive tasks following severe closed-head injury. , 2006, Neuropsychology.

[25]  G. E. Alexander,et al.  Basal ganglia-thalamocortical circuits: parallel substrates for motor, oculomotor, "prefrontal" and "limbic" functions. , 1990, Progress in brain research.

[26]  Thomas E. Nichols,et al.  Switching attention and resolving interference: fMRI measures of executive functions , 2003, Neuropsychologia.

[27]  S. Carey,et al.  From piecemeal to configurational representation of faces. , 1977, Science.

[28]  Mark H. Johnson,et al.  Components of Visual Orienting in Early Infancy: Contingency Learning, Anticipatory Looking, and Disengaging , 1991, Journal of Cognitive Neuroscience.

[29]  A. Dove,et al.  Prefrontal cortex activation in task switching: an event-related fMRI study. , 2000, Brain research. Cognitive brain research.

[30]  N. Minshew,et al.  Maturation of Widely Distributed Brain Function Subserves Cognitive Development , 2001, NeuroImage.

[31]  J. Rapoport,et al.  Quantitative brain magnetic resonance imaging in attention-deficit hyperactivity disorder. , 1996, Archives of general psychiatry.

[32]  N. Meiran.  Reconfiguration of processing mode prior to task performance. , 1996 .

[33]  A. Diamond,et al.  Rate of Maturation of the Hippocampus and the Developmental Progression of Children's Performance on the Delayed Non‐Matching to Sample and Visual Paired Comparison Tasks a , 1990, Annals of the New York Academy of Sciences.

[34]  P. Redgrave,et al.  Is the short-latency dopamine response too short to signal reward error? , 1999, Trends in Neurosciences.

[35]  Leslie G. Ungerleider,et al.  The Representation of Objects in the Human Occipital and Temporal Cortex , 2000, Journal of Cognitive Neuroscience.

[36]  M. Goldsmith,et al.  Statistical Learning by 8-Month-Old Infants , 1996 .

[37]  T. Robbins,et al.  Mechanisms of cognitive set flexibility in Parkinson's disease. , 2001, Brain : a journal of neurology.

[38]  S. Carey,et al.  Developmental changes in the representation of faces. , 1977, Journal of experimental child psychology.

[39]  Jane E Joseph,et al.  Natural and manufactured objects activate the fusiform face area , 2002, Neuroreport.

[40]  K. Kunz,et al.  Dissociating Striatal and Hippocampal Function Developmentally with a Stimulus–Response Compatibility Task , 2002, The Journal of Neuroscience.

[41]  A. Treisman.  Features and Objects: The Fourteenth Bartlett Memorial Lecture , 1988, The Quarterly journal of experimental psychology. A, Human experimental psychology.

[42]  A. Toga,et al.  In vivo evidence for post-adolescent brain maturation in frontal and striatal regions , 1999, Nature Neuroscience.

[43]  G. E. Alexander,et al.  Parallel organization of functionally segregated circuits linking basal ganglia and cortex. , 1986, Annual review of neuroscience.

[44]  T. Shallice.  Neurological impairment of cognitive processes. , 1981, British medical bulletin.

[45]  G. Berns,et al.  Brain regions responsive to novelty in the absence of awareness. , 1997, Science.

[46]  Joseph A Mindell,et al.  The Poststructural Festivities Begin , 2003, Neuron.

[47]  Y. Vauss,et al.  Cognitive functioning in sydenham's chorea: Part 1. attentional processes , 1994 .

[48]  R W Cox,et al.  AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. , 1996, Computers and biomedical research, an international journal.

[49]  I. Creese.  Stimulants, neurochemical, behavioral, and clinical perspectives , 1983 .

[50]  M. Tarr,et al.  Unraveling mechanisms for expert object recognition: bridging brain activity and behavior. , 2002, Journal of experimental psychology. Human perception and performance.

[51]  A Baddeley,et al.  Modularity, mass-action and memory. , 1986, The Quarterly journal of experimental psychology. A, Human experimental psychology.

[52]  S. Tipper,et al.  Mechanisms of attention: a developmental study. , 1989, Journal of experimental child psychology.

[53]  V. Reyna,et al.  Domains of Fuzzy-Trace Theory , 1993 .

[54]  J S Fowler,et al.  Mechanism of action of methylphenidate: Insights from PET imaging studies , 2002, Journal of attention disorders.

[55]  J. Driver,et al.  Control of Cognitive Processes: Attention and Performance XVIII , 2000 .

[56]  J. Cohen,et al.  Dissociating the role of the dorsolateral prefrontal and anterior cingulate cortex in cognitive control. , 2000, Science.

[57]  B. J. Casey,et al.  Differential patterns of striatal activation in young children with and without ADHD , 2003, Biological Psychiatry.

[58]  A. Karmiloff-Smith.  From meta-processes to conscious access: Evidence from children's metalinguistic and repair data , 1986, Cognition.

[59]  A. Cools.  Role of the neostriatal dopaminergic activity in sequencing and selecting behavioural strategies: Facilitation of processes involved in selecting the best strategy in a stressful situation , 1980, Behavioural Brain Research.

[60]  M. D’Esposito,et al.  Modulation of task-related neural activity in task-switching: an fMRI study. , 2000, Brain research. Cognitive brain research.

[61]  A. Kramer,et al.  Task Switching and Attention Deficit Hyperactivity Disorder , 2000, Journal of abnormal child psychology.

[62]  J. Mazziotta,et al.  Rapid Automated Algorithm for Aligning and Reslicing PET Images , 1992, Journal of computer assisted tomography.

[63]  T. Shallice.  From Neuropsychology to Mental Structure: Converging Operations: Specific Syndromes and Evidence from Normal Subjects , 1988 .

[64]  Jonathan D. Cohen,et al.  Conflict monitoring versus selection-for-action in anterior cingulate cortex , 1999, Nature.

[65]  Alan D. Baddeley,et al.  Editorial: Modularity, Mass-Action and Memory , 1986 .

[66]  P. Zelazo,et al.  Theory of mind and rule use in individuals with Down's syndrome: a test of the uniqueness and specificity claims. , 1996, Journal of child psychology and psychiatry, and allied disciplines.

[67]  D. Bjorklund,et al.  The Ontogeny of Inhibition Mechanisms: A Renewed Approach to Cognitive Development , 1993 .

[68]  Jagath C. Rajapakse,et al.  Quantitative Magnetic Resonance Imaging of Human Brain Development: Ages 4–18 , 1996 .

[69]  S. Rauch,et al.  Thalamic deactivation during early implicit sequence learning: a functional MRI study , 1998, Neuroreport.

[70]  C. Izard,et al.  Developmental changes in the use of emotion cues in a concept-formation task. , 1970 .

[71]  F. N. Dempster,et al.  Resistance to Interference: Developmental Changes in a Basic Processing Mechanism , 1993 .

[72]  D. Kahneman,et al.  The cost of visual filtering. , 1983, Journal of experimental psychology. Human perception and performance.

[73]  D. Alan Allport,et al.  SHIFTING INTENTIONAL SET - EXPLORING THE DYNAMIC CONTROL OF TASKS , 1994 .

[74]  John R. Anderson,et al.  The role of prefrontal cortex and posterior parietal cortex in task switching. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[75]  M. Corbetta,et al.  Selective and divided attention during visual discriminations of shape, color, and speed: functional anatomy by positron emission tomography , 1991, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[76]  E. Miller,et al.  An integrative theory of prefrontal cortex function. , 2001, Annual review of neuroscience.

[77]  J. Cohen,et al.  Context, cortex, and dopamine: a connectionist approach to behavior and biology in schizophrenia. , 1992, Psychological review.

[78]  K. A. Hadland,et al.  Role of the human medial frontal cortex in task switching: a combined fMRI and TMS study. , 2002, Journal of neurophysiology.

[79]  Samuel M. McClure,et al.  Temporal Prediction Errors in a Passive Learning Task Activate Human Striatum , 2003, Neuron.

[80]  C. Nelson,et al.  Serial reaction time learning in preschool- and school-age children. , 2001, Journal of experimental child psychology.