Dissociable roles of the posterior parietal and the prefrontal cortex in manipulation and monitoring processes

Numerous functional neuroimaging studies reported increased activity in the middorsolateral prefrontal cortex (MDLFC) and the posterior parietal cortex (PPC) during the performance of working memory tasks. However, the role of the PPC in working memory is not understood and, although there is strong evidence that the MDLFC is involved in the monitoring of information in working memory, it is also often stated that it is involved in the manipulation of such information. This event-related functional magnetic resonance imaging study compared brain activity during the performance of working memory trials in which either monitoring or manipulation of information was required. The results show that the PPC is centrally involved in manipulation processes, whereas activation of the MDLFC is related to the monitoring of the information that is being manipulated. This study provides dissociation of activation in these two regions and, thus, succeeds in further specifying their relative contribution to working memory.

[1]  Stanislas Dehaene,et al.  Cerebral Pathways for Calculation: Double Dissociation between Rote Verbal and Quantitative Knowledge of Arithmetic , 1997, Cortex.

[2]  Bruce R. Rosen,et al.  Activity in Ventrolateral and Mid-Dorsolateral Prefrontal Cortex during Nonspatial Visual Working Memory Processing: Evidence from Functional Magnetic Resonance Imaging , 2000, NeuroImage.

[3]  M Petrides,et al.  Monitoring of selections of visual stimuli and the primate frontal cortex , 1991, Proceedings of the Royal Society of London. Series B: Biological Sciences.

[4]  Richard S. J. Frackowiak,et al.  The neural correlates of the verbal component of working memory , 1993, Nature.

[5]  A. Georgopoulos,et al.  Functional magnetic resonance imaging of mental rotation and memory scanning: a multidimensional scaling analysis of brain activation patterns 1 Published on the World Wide Web on 24 February 1998. 1 , 1998, Brain Research Reviews.

[6]  J. Gerstmann.  SYNDROME OF FINGER AGNOSIA, DISORIENTATION FOR RIGHT AND LEFT, AGRAPHIA AND ACALCULIA: LOCAL DIAGNOSTIC VALUE , 1940 .

[7]  Alan C. Evans,et al.  A General Statistical Analysis for fMRI Data , 2000, NeuroImage.

[8]  Guy A. Orban,et al.  The Neural Substrate of Orientation Working Memory , 2001, Journal of Cognitive Neuroscience.

[9]  M. Inase,et al.  Neuroanatomical discrimination between manipulating and maintaining processes involved in verbal working memory; a functional MRI study. , 2001, Brain research. Cognitive brain research.

[10]  Ivan Toni,et al.  Neural Topography and Content of Movement Representations , 2005, Journal of Cognitive Neuroscience.

[11]  D. Collins,et al.  Automatic 3D Intersubject Registration of MR Volumetric Data in Standardized Talairach Space , 1994, Journal of computer assisted tomography.

[12]  R W Cox,et al.  Real‐time 3D image registration for functional MRI , 1999, Magnetic resonance in medicine.

[13]  M. Petrides,et al.  Functional activation of the human brain during mental rotation , 1997, Neuropsychologia.

[14]  G. Ratcliff.  Spatial thought, mental rotation and the right cerebral hemisphere , 1979, Neuropsychologia.

[15]  J. Talairach,et al.  Co-Planar Stereotaxic Atlas of the Human Brain: 3-Dimensional Proportional System: An Approach to Cerebral Imaging , 1988 .

[16]  B. Milner,et al.  Deficits on subject-ordered tasks after frontal- and temporal-lobe lesions in man , 1982, Neuropsychologia.

[17]  B. Alivisatos.  The role of the frontal cortex in the use of advance information in a mental rotation paradigm , 1992, Neuropsychologia.

[18]  Raffaella I. Rumiati,et al.  Effects of Strategies on Mental Rotation and Hemispheric Lateralization: Neuropsychological Evidence , 2004, Journal of Cognitive Neuroscience.

[19]  Karl J. Friston,et al.  Psychophysiological and Modulatory Interactions in Neuroimaging , 1997, NeuroImage.

[20]  Karl J. Friston,et al.  A unified statistical approach for determining significant signals in images of cerebral activation , 1996, Human brain mapping.

[21]  C. Degueldre,et al.  Regional brain activity during tasks devoted to the central executive of working memory. , 1999, Brain research. Cognitive brain research.

[22]  Alan C. Evans,et al.  Functional activation of the human frontal cortex during the performance of verbal working memory tasks. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[23]  M. Petrides.  Lateral prefrontal cortex: architectonic and functional organization , 2005, Philosophical Transactions of the Royal Society B: Biological Sciences.

[24]  J. Duncan,et al.  Encoding Strategies Dissociate Prefrontal Activity from Working Memory Demand , 2003, Neuron.

[25]  B. Postle,et al.  Prefrontal cortical contributions to working memory: evidence from event-related fMRI studies , 2000, Experimental Brain Research.

[26]  S. Dehaene,et al.  THREE PARIETAL CIRCUITS FOR NUMBER PROCESSING , 2003, Cognitive neuropsychology.

[27]  Edward E. Smith,et al.  The Role of Parietal Cortex in Verbal Working Memory , 1998, The Journal of Neuroscience.

[28]  M Petrides,et al.  Impairments on nonspatial self-ordered and externally ordered working memory tasks after lesions of the mid-dorsal part of the lateral frontal cortex in the monkey , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[29]  J. Jonides,et al.  Neuroimaging analyses of human working memory. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[30]  B. Postle,et al.  Functional neuroanatomical double dissociation of mnemonic and executive control processes contributing to working memory performance. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[31]  M. Petrides,et al.  Specialized systems for the processing of mnemonic information within the primate frontal cortex. , 1996, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[32]  Karl J. Friston,et al.  Analysis of fMRI Time-Series Revisited , 1995, NeuroImage.