Insulin-like Effect of Zinc on Adipocytes

SUMMARY In view of the known effect of zinc on the crystalline nature of insulin, we have investigated whether zinc alters the biologic potency of this hormone. Using the rate of lipogenesis by rat epididymal adipocytes as an index of the biologic potency of insulin, we have shown that zinc exerts a potent stimulatory effect upon lipogenesis in vitro similar to, but quite independently of, insulin and that it has an additive effect with that of insulin when both are incubated together. This effect of zinc on adipocytes and the biologic potency of insulin, hitherto unreported, is of significance at the biologic, pharmacologie, and clinical level.

[1]  D. Parke,et al.  The tissue disposition and urinary excretion of cadmium, zinc, copper and iron, following repeated parenteral administration of cadmium to rats. , 1979, Chemico-biological interactions.

[2]  S. Miyamoto,et al.  The effect of zinc on insulin metabolism. , 1978, Endocrinology.

[3]  R. Jaenicke,et al.  Effect of zinc(II) on the refolding and reactivation of liver alcohol dehydrogenase. , 1978, European journal of biochemistry.

[4]  G. Reaven,et al.  Insulin Binding in Diabetes: Relationships with Plasma Insulin Levels and Insulin Sensitivity , 1977, Diabetes.

[5]  P. Lacy,et al.  ISOLATION AND PROPERTIES OF SECRETORY GRANULES FROM RAT ISLETS OF LANGERHANS , 1969, The Journal of cell biology.

[6]  P. Lacy,et al.  ISOLATION AND PROPERTIES OF SECRETORY GRANULES FROM RAT ISLETS OF LANGERHANS , 1969, The Journal of cell biology.

[7]  M. Rodbell.  METABOLISM OF ISOLATED FAT CELLS. I. EFFECTS OF HORMONES ON GLUCOSE METABOLISM AND LIPOLYSIS. , 1964, The Journal of biological chemistry.

[8]  G. Reaven,et al.  Nonketotic diabetes mellitus: insulin deficiency or insulin resistance? , 1976, The American journal of medicine.

[9]  B. Hellman,et al.  Evidence for a role of zinc in the storage of insulin in the mouse pancreatic b-cells. Abstr. , 1976 .

[10]  A. Moody,et al.  A Simple Free Fat Cell Bioassay for Insulin , 1974, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[11]  Tom L. Blundell,et al.  Insulin: The Structure in the Crystal and its Reflection in Chemistry and Biology by , 1972 .

[12]  J. Marks.  Insulin binding. , 1969, Pediatrics.