A Catalytic Enantioselective Synthesis of Denopamine, a Useful Drug for Congestive Heart Failure.

Described here is a practical route to enantiomerically pure (R)-(-)-denopamine or its enantiomer in>60% overall yield that does not involve chromatography. This route demonstrates the applicability of the recently described enantioselective catalytic reduction process to the synthesis of enantiomerically pure members of the therapeutically significant arylethanolamine drug class