The Nedd8 Non-covalent Binding Region in the Smurf HECT Domain is Critical to its Ubiquitn Ligase Function

[1]  Yu Cao,et al.  The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis , 2014, Nature Communications.

[2]  K. Hofmann,et al.  TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes , 2013, The EMBO journal.

[3]  Shaomeng Wang,et al.  RNF111-dependent neddylation activates DNA damage-induced ubiquitination. , 2013, Molecular cell.

[4]  R. Singh,et al.  Recognition and Cleavage of Related to Ubiquitin 1 (Rub1) and Rub1-Ubiquitin Chains by Components of the Ubiquitin-Proteasome System* , 2012, Molecular & Cellular Proteomics.

[5]  A. Knebel,et al.  UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1α accumulation , 2012, BMC Biology.

[6]  R. Deshaies,et al.  NEDD8 links Cullin–Ring ubiquitin Ligase function to the p97 pathway , 2012, Nature Structural &Molecular Biology.

[7]  R. Ambinder,et al.  De Novo DNA Methyltransferase DNMT3b Interacts with NEDD8-modified Proteins* , 2010, The Journal of Biological Chemistry.

[8]  Dimitris P. Xirodimas,et al.  NUB1 promotes cytoplasmic localization of p53 through cooperation of the NEDD8 and ubiquitin pathways , 2010, Oncogene.

[9]  J. Wrana,et al.  The Ubiquitin Binding Region of the Smurf HECT Domain Facilitates Polyubiquitylation and Binding of Ubiquitylated Substrates* , 2009, The Journal of Biological Chemistry.

[10]  D. Katzmann,et al.  The HECT Domain of the Ubiquitin Ligase Rsp5 Contributes to Substrate Recognition* , 2009, The Journal of Biological Chemistry.

[11]  J. Wrana,et al.  Regulation of Planar Cell Polarity by Smurf Ubiquitin Ligases , 2009, Cell.

[12]  K. Jacobson,et al.  Talin Phosphorylation by Cdk5 regulates Smurf1-mediated talin head ubiquitination and cell migration , 2009, Nature Cell Biology.

[13]  E. Brambilla,et al.  Altered pattern of Cul-1 protein expression and neddylation in human lung tumours: relationships with CAND1 and cyclin E protein levels. , 2007, The Journal of pathology.

[14]  Kongthawat Chairatvit,et al.  Control of cell proliferation via elevated NEDD8 conjugation in oral squamous cell carcinoma , 2007, Molecular and Cellular Biochemistry.

[15]  G. Cesareni,et al.  Conjugation to Nedd8 Instigates Ubiquitylation and Down-regulation of Activated Receptor Tyrosine Kinases* , 2006, Journal of Biological Chemistry.

[16]  Yue Zhang,et al.  Regulation of Cell Polarity and Protrusion Formation by Targeting RhoA for Degradation , 2003, Science.

[17]  E. Yeh,et al.  Regulation of the NEDD8 Conjugation System by a Splicing Variant, NUB1L* , 2003, Journal of Biological Chemistry.

[18]  M. Estelle,et al.  The RUB/Nedd8 conjugation pathway is required for early development in Arabidopsis , 2003, The EMBO journal.

[19]  Cheng-Ting Chien,et al.  Distinct protein degradation mechanisms mediated by Cul1 and Cul3 controlling Ci stability in Drosophila eye development. , 2002, Genes & development.

[20]  E. Yeh,et al.  Targeting of NEDD8 and Its Conjugates for Proteasomal Degradation by NUB1* , 2001, The Journal of Biological Chemistry.

[21]  Keiji Tanaka,et al.  The NEDD8 system is essential for cell cycle progression and morphogenetic pathway in mice , 2001, The Journal of cell biology.

[22]  E. Candido,et al.  The NED-8 conjugating system in Caenorhabditis elegans is required for embryogenesis and terminal differentiation of the hypodermis. , 2000, Developmental biology.

[23]  T. Toda,et al.  Covalent modifier NEDD8 is essential for SCF ubiquitin‐ligase in fission yeast , 2000, The EMBO journal.

[24]  Keiji Tanaka,et al.  Covalent modification of all members of human cullin family proteins by NEDD8 , 1999, Oncogene.

[25]  L. Caskey,et al.  Cleavage of the C-terminus of NEDD8 by UCH-L3. , 1998, Biochemical and biophysical research communications.

[26]  E. Yeh,et al.  Characterization of NEDD8, a Developmentally Down-regulated Ubiquitin-like Protein* , 1997, The Journal of Biological Chemistry.