The role of toxin A and toxin B in Clostridium difficile infection

[1]  J. Heap,et al.  The ClosTron: Mutagenesis in Clostridium refined and streamlined. , 2010, Journal of microbiological methods.

[2]  N. Minton,et al.  A mariner-Based Transposon System for In Vivo Random Mutagenesis of Clostridium difficile , 2009, Applied and Environmental Microbiology.

[3]  J. Heap,et al.  A modular system for Clostridium shuttle plasmids. , 2009, Journal of microbiological methods.

[4]  Julian I. Rood,et al.  Toxin B is essential for virulence of Clostridium difficile , 2009, Nature.

[5]  B. Wren,et al.  Comparative analysis of BI/NAP1/027 hypervirulent strains reveals novel toxin B-encoding gene (tcdB) sequences. , 2008, Journal of medical microbiology.

[6]  A. Sonenshein,et al.  Bile Salts and Glycine as Cogerminants for Clostridium difficile Spores , 2008, Journal of bacteriology.

[7]  J. Heap,et al.  The ClosTron: a universal gene knock-out system for the genus Clostridium. , 2007, Journal of microbiological methods.

[8]  M. Hannan,et al.  Emergence and Control of Fluoroquinolone-Resistant, Toxin A–Negative, Toxin B–Positive Clostridium difficile , 2007, Infection Control & Hospital Epidemiology.

[9]  S. Fanning,et al.  Toxin A-negative, toxin B-positive Clostridium difficile. , 2007, International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.

[10]  J. Hinds,et al.  Construction and analysis of chromosomal Clostridium difficile mutants , 2006, Molecular microbiology.

[11]  Julian Parkhill,et al.  The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome , 2006, Nature Genetics.

[12]  J. Ballard,et al.  Clostridium difficile Toxins: Mechanism of Action and Role in Disease , 2005, Clinical Microbiology Reviews.

[13]  A. Roberts,et al.  Generation of an erythromycin-sensitive derivative of Clostridium difficile strain 630 (630Deltaerm) and demonstration that the conjugative transposon Tn916DeltaE enters the genome of this strain at multiple sites. , 2005, Journal of medical microbiology.

[14]  S. Poutanen,et al.  Clostridium difficile-associated diarrhea in adults , 2004, Canadian Medical Association Journal.

[15]  M. Alfa,et al.  Translocation of Clostridium difficile toxin B across polarized Caco-2 cell monolayers is enhanced by toxin A. , 2004, The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses.

[16]  I. Just,et al.  Large clostridial cytotoxins. , 2004, Reviews of physiology, biochemistry and pharmacology.

[17]  C. Guzmán-Verri,et al.  R-Ras Glucosylation and Transient RhoA Activation Determine the Cytopathic Effect Produced by Toxin B Variants from Toxin A-negative Strains of Clostridium difficile * , 2003, The Journal of Biological Chemistry.

[18]  M. Alfa,et al.  Characterization of a Toxin A-Negative, Toxin B-Positive Strain of Clostridium difficile Responsible for a Nosocomial Outbreak of Clostridium difficile-Associated Diarrhea , 2000, Journal of Clinical Microbiology.

[19]  M. Camorlinga-Ponce,et al.  Sensitivity in culture of epithelial cells from rhesus monkey kidney and human colon carcinoma to toxins A and B from Clostridium difficile. , 1992, Toxicon : official journal of the International Society on Toxinology.

[20]  J. Torres.  Purification and characterisation of toxin B from a strain of Clostridium difficile that does not produce toxin A. , 1991, Journal of medical microbiology.

[21]  M. Young,et al.  Conjugative plasmid transfer from Escherichia coli to Clostridium acetobutylicum. , 1990, Journal of general microbiology.

[22]  P. Kim,et al.  Immunization of adult hamsters against Clostridium difficile-associated ileocecitis and transfer of protection to infant hamsters , 1987, Infection and immunity.

[23]  B. Berger-Bächi,et al.  Genetic characterization of a Clostridium difficile erythromycin-clindamycin resistance determinant that is transferable to Staphylococcus aureus , 1987, Antimicrobial Agents and Chemotherapy.

[24]  K. Saum,et al.  Effects of Clostridium difficile toxins given intragastrically to animals , 1985, Infection and immunity.

[25]  R. Brettle,et al.  Clostridium difficile-associated diarrhoea. , 1984, The Journal of infection.

[26]  J. Sambrook,et al.  Molecular Cloning: A Laboratory Manual , 2001 .