Dissecting protein tyrosine phosphatase signaling by engineered chemogenetic control of its activity

Fauser et al. engineer a chemogenetic allosteric switch that allows for the regulation of the activity of protein tyrosine phosphatases, as well as for their activation within specific protein complexes. Using this tool, they dissect parallel signaling pathways and identify dynamic processes regulated by different Shp2-mediated signaling complexes.

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