Surface-enhanced Raman nanodomes

We demonstrate a surface-enhanced Raman scattering (SERS) substrate consisting of a closely spaced metal nanodome array fabricated on flexible plastic film. We used a low-cost, large-area replica molding process to produce a two-dimensional periodic array of cylinders that is subsequently overcoated with SiO(2) and silver thin films to form dome-shaped structures. Finite element modeling was used to investigate the electromagnetic field distribution of the nanodome array structure and the effect of the nanodome separation distance on the electromagnetic field enhancement. The SERS enhancement from the nanodome array substrates was experimentally verified using rhodamine 6G as the analyte. With a separation distance of 17 nm achieved between adjacent domes using a process that is precisely controlled during thin film deposition, a reproducible SERS enhancement factor of 1.37 × 10(8) was demonstrated. The nanoreplica molding process presented in this work allows for simple, low-cost, high-throughput fabrication of uniform nanoscale SERS substrates over large surface areas without the requirement for high resolution lithography or defect-free deposition of spherical microparticle monolayer templates.

[1]  S. B. Chaney,et al.  Polarized surface enhanced Raman and absorbance spectra of aligned silver nanorod arrays. , 2006, The journal of physical chemistry. B.

[2]  D. L. Jeanmaire,et al.  Surface raman spectroelectrochemistry: Part I. Heterocyclic, aromatic, and aliphatic amines adsorbed on the anodized silver electrode , 1977 .

[3]  A. Campion,et al.  Surface-enhanced Raman scattering , 1998 .

[4]  Rashid Bashir,et al.  A detection instrument for enhanced-fluorescence and label-free imaging on photonic crystal surfaces. , 2009, Optics express.

[5]  Charles J. Choi,et al.  Single-step fabrication and characterization of photonic crystal biosensors with polymer microfluidic channels. , 2006, Lab on a chip.

[6]  Jeffrey N. Anker,et al.  Surface-enhanced Raman spectroscopy of benzenethiol adsorbed from the gas phase onto silver film over nanosphere surfaces: determination of the sticking probability and detection limit time. , 2009, The journal of physical chemistry. A.

[7]  M. Porter,et al.  Femtomolar detection of prostate-specific antigen: an immunoassay based on surface-enhanced Raman scattering and immunogold labels. , 2003, Analytical chemistry.

[8]  J. Kneipp.  Nanosensors Based on SERS for Applications in Living Cells , 2006 .

[9]  Luke P. Lee,et al.  Nanophotonic crescent moon structures with sharp edge for ultrasensitive biomolecular detection by local electromagnetic field enhancement effect. , 2005, Nano letters.

[10]  R. Goodacre,et al.  Discrimination of bacteria using surface-enhanced Raman spectroscopy. , 2004, Analytical chemistry.

[11]  C. Haynes,et al.  Plasmonic Materials for Surface-Enhanced Sensing and Spectroscopy , 2005 .

[12]  P G Etchegoin,et al.  A perspective on single molecule SERS: current status and future challenges. , 2008, Physical chemistry chemical physics : PCCP.

[13]  John A. Rogers,et al.  Molded plasmonic crystals for detecting and spatially imaging surface bound species by surface-enhanced Raman scattering , 2009 .

[14]  Wei Zhang,et al.  Enhanced fluorescence on a photonic crystal surface incorporating nanorod structures. , 2008, Small.

[15]  L. Pacheco-Londoño,et al.  Nanotechnology-Based Detection of Explosives and Biological Agents Simulants , 2008, IEEE Sensors Journal.

[16]  B. Cunningham,et al.  Rapid Specific and Label-Free Detection of Porcine Rotavirus Using Photonic Crystal Biosensors , 2009, IEEE Sensors Journal.

[17]  Luca Dal Negro,et al.  Plasmonic nanogalaxies: multiscale aperiodic arrays for surface-enhanced Raman sensing. , 2009, Nano letters.

[18]  M. Moskovits.  Surface-enhanced spectroscopy , 1985 .

[19]  Naomi J Halas,et al.  Direct optical detection of aptamer conformational changes induced by target molecules. , 2009, Analytical chemistry.

[20]  D. McLean,et al.  Automated Autofluorescence Background Subtraction Algorithm for Biomedical Raman Spectroscopy , 2007, Applied spectroscopy.

[21]  N. Pieczonka,et al.  Single Molecule Analysis by Surfaced‐Enhanced Raman Scattering , 2008 .

[22]  C. Haynes,et al.  Nanosphere Lithography: A Versatile Nanofabrication Tool for Studies of Size-Dependent Nanoparticle Optics , 2001 .

[23]  N. Shah,et al.  Surface-enhanced Raman spectroscopy. , 2008, Annual review of analytical chemistry.

[24]  M. Fleischmann,et al.  Raman spectra of pyridine adsorbed at a silver electrode , 1974 .

[25]  Luke P. Lee,et al.  Nanowell surface enhanced Raman scattering arrays fabricated by soft-lithography for label-free biomolecular detections in integrated microfluidics , 2005 .

[26]  B. Cunningham,et al.  Optically tuned resonant optical reflectance filter , 2008 .

[27]  Sung-Jin Park,et al.  Microcavity Plasma Devices and Arrays Fabricated by Plastic-Based Replica Molding , 2007, Journal of Microelectromechanical Systems.

[28]  Franz R. Aussenegg,et al.  Optimized surface-enhanced Raman scattering on gold nanoparticle arrays , 2003 .

[29]  N. Pieczonka,et al.  Single molecule analysis by surfaced-enhanced Raman scattering. , 2008, Chemical Society reviews.

[30]  R. Dasari,et al.  Single Molecule Detection Using Surface-Enhanced Raman Scattering (SERS) , 1997 .

[31]  B. Cunningham,et al.  Label-Free Photonic Crystal Biosensor Integrated Microfluidic Chip for Determination of Kinetic Reaction Rate Constants , 2009, IEEE Sensors Journal.

[32]  C. Mirkin,et al.  Nanoparticles with Raman spectroscopic fingerprints for DNA and RNA detection. , 2002, Science.

[33]  Hongxing Xu,et al.  Interparticle coupling effects in nanofabricated substrates for surface-enhanced Raman scattering , 2001 .

[34]  Yiping Zhao,et al.  Rapid and sensitive detection of respiratory virus molecular signatures using a silver nanorod array SERS substrate. , 2006, Nano letters.

[35]  S. Gaponenko,et al.  Raman scattering enhancement using crystallographic surface of a colloidal crystal , 2001 .

[36]  J. Popp,et al.  Surface-enhanced Raman spectroscopy , 2009, Analytical and bioanalytical chemistry.

[37]  Sergey V. Gaponenko,et al.  Possible rationale for ultimate enhancement factor in single molecule Raman spectroscopy , 2009 .

[38]  Steven R. Emory,et al.  Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering , 1997, Science.

[39]  N. P. Economou,et al.  Surface-enhanced raman scattering from microlithographic silver particle surfaces , 1981 .

[40]  A. Hohenau,et al.  Gold particle interaction in regular arrays probed by surface enhanced Raman scattering. , 2004, The Journal of chemical physics.

[41]  Gregory J. Slavik,et al.  A replica molding technique for producing fibrous chitosan scaffolds for cartilage engineering , 2007 .

[42]  Brian T. Cunningham,et al.  Label free biosensor incorporating a replica-molded, vertically emitting distributed feedback laser , 2008 .

[43]  Charles J. Choi,et al.  A 96-well microplate incorporating a replica molded microfluidic network integrated with photonic crystal biosensors for high throughput kinetic biomolecular interaction analysis. , 2007, Lab on a chip.

[44]  Lance G. Laing,et al.  Label-Free Assays on the BIND System , 2004, Journal of biomolecular screening.

[45]  Viktor Malyarchuk,et al.  Enhanced fluorescence emission from quantum dots on a photonic crystal surface , 2007, Nature Nanotechnology.

[46]  L. Dick,et al.  Metal film over nanosphere (MFON) electrodes for surface-enhanced Raman spectroscopy (SERS): Improvements in surface nanostructure stability and suppression of irreversible loss , 2002 .