Imaging innovations for cancer therapy response monitoring

Innovative imaging approaches for monitoring various types of cancer treatment response are discussed in this paper. Radionuclide imaging has demonstrated favorable capabilities for imaging tumor response based on the binding of radionuclides to the cells responding to the treatment. MRI has recently been utilized for detecting the cellular changes associated with apoptosis. Dynamic contrast-enhanced ultrasound has been proposed for monitoring therapeutics that target blood vessels affecting perfusion. Quantitative ultrasound has been demonstrated to be capable of differentiating between viable cell clusters and clusters responding to treatment. Diffuse optical imaging and photoacoustic imaging have been applied for evaluating functional changes transpiring in soft tissue, such as oxygenation status, during cancer treatment. Considerable developments introduced to improve the precision of treatment response monitoring are expected in the near future to provide clinical approaches to personalized therapy in which therapies can be adapted based on the detection of functional physiology-based responses.

[1]  B. Tromberg,et al.  Diffuse optical spectroscopic imaging correlates with final pathological response in breast cancer neoadjuvant chemotherapy , 2011, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[2]  Michael C. Kolios,et al.  Effects of erythrocyte oxygenation on optoacoustic signals. , 2011, Journal of biomedical optics.

[3]  Xinmai Yang,et al.  Real-time monitoring of high-intensity focused ultrasound ablations with photoacoustic technique: an in vitro study. , 2011, Medical physics.

[4]  P. Burns,et al.  The lognormal perfusion model for disruption replenishment measurements of blood flow: in vivo validation. , 2011, Ultrasound in medicine & biology.

[5]  Junjie Yao,et al.  Photoacoustic tomography: fundamentals, advances and prospects. , 2011, Contrast media & molecular imaging.

[6]  T. Tuthill,et al.  Use of Ultrasound to Assess Drug Efficacy in Orthotopic Rat Models of HCC , 2011 .

[7]  B. Tromberg,et al.  Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment , 2011, Proceedings of the National Academy of Sciences.

[8]  D O Cosgrove,et al.  Quantitative contrast-enhanced ultrasound imaging: a review of sources of variability , 2011, Interface Focus.

[9]  Ross Williams,et al.  Improved flow measurement using microbubble contrast agents and disruption-replenishment: clinical application to tumour monitoring. , 2011, Ultrasound in medicine & biology.

[10]  Nikita Reznik,et al.  Investigation of vaporized submicron perfluorocarbon droplets as an ultrasound contrast agent. , 2011, Ultrasound in medicine & biology.

[11]  J. Griffiths,et al.  MRI & MRS assessment of the role of the tumour microenvironment in response to therapy , 2011, NMR in biomedicine.

[12]  G. Stanisz,et al.  Quantitative magnetization transfer studies of apoptotic cell death , 2011, Magnetic resonance in medicine.

[13]  Junjie Yao,et al.  Label-free oxygen-metabolic photoacoustic microscopy in vivo. , 2011, Journal of biomedical optics.

[14]  Thomas E. Yankeelov,et al.  Earlier detection of tumor treatment response using magnetic resonance diffusion imaging with oscillating gradients. , 2011, Magnetic resonance imaging.

[15]  John C Gore,et al.  Effects of intracellular organelles on the apparent diffusion coefficient of water molecules in cultured human embryonic kidney cells , 2011, Magnetic resonance in medicine.

[16]  Michael C. Kolios,et al.  Detecting abnormal vasculature from photoacoustic signals using wavelet-packet features , 2011, BiOS.

[17]  Lucy E. Kershaw,et al.  A general dual-bolus approach for quantitative DCE-MRI. , 2011, Magnetic resonance imaging.

[18]  Michael C. Kolios,et al.  Study of laser-induced thermoelastic deformation of native and coagulated ex-vivo bovine liver tissues for estimating their optical and thermomechanical properties. , 2010, Journal of biomedical optics.

[19]  Michael C. Kolios,et al.  Conventional frequency evaluation of tumor cell death response in locally advanced breast cancer patients to chemotherapy treatment administration. , 2010 .

[20]  Michael C. Kolios,et al.  Conventional frequency evaluation of tumor cell death in response to treatment in vivo. , 2010 .

[21]  V. Ntziachristos,et al.  Video rate optoacoustic tomography of mouse kidney perfusion. , 2010, Optics letters.

[22]  Wenfeng Xia,et al.  Photoacoustic Imaging of the Breast Using the Twente Photoacoustic Mammoscope: Present Status and Future Perspectives , 2010, IEEE Journal of Selected Topics in Quantum Electronics.

[23]  M. Yaffe,et al.  Functional Imaging Using Diffuse Optical Spectroscopy of Neoadjuvant Chemotherapy Response in Women with Locally Advanced Breast Cancer , 2010, Clinical Cancer Research.

[24]  V. Ntziachristos,et al.  Molecular imaging by means of multispectral optoacoustic tomography (MSOT). , 2010, Chemical reviews.

[25]  Greg J. Stanisz,et al.  Diffusion MR in Biological Systems: Tissue Compartments and Exchange , 2010 .

[26]  Richard Su,et al.  Feasibility of optoacoustic visualization of high-intensity focused ultrasound-induced thermal lesions in live tissue. , 2010, Journal of biomedical optics.

[27]  S. L. Bridal,et al.  Clinical relevance of contrast-enhanced ultrasound in monitoring anti-angiogenic therapy of cancer: current status and perspectives. , 2010, Critical reviews in oncology/hematology.

[28]  Gregory J. Czarnota,et al.  Ultrasound detection of cell death , 2010 .

[29]  M. Averkiou,et al.  Investigation of the relationship of nonlinear backscattered ultrasound intensity with microbubble concentration at low MI. , 2010, Ultrasound in medicine & biology.

[30]  Michael C. Kolios,et al.  Potential use of ultrasound for the detection of cell changes in cancer treatment. , 2009, Future oncology.

[31]  Stanislav Emelianov,et al.  On sensitivity of molecular specific photoacoustic imaging using plasmonic gold nanoparticles , 2009, 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[32]  Lihong V. Wang.  Multiscale photoacoustic microscopy and computed tomography. , 2009, Nature photonics.

[33]  Gregory J Czarnota,et al.  Detection of apoptotic cell death in vitro in the presence of Gd‐DTPA‐BMA , 2009, Magnetic resonance in medicine.

[34]  R. Ichord,et al.  Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury. , 2009, Journal of biomedical optics.

[35]  John C Gore,et al.  Sensitivity of MR diffusion measurements to variations in intracellular structure: Effects of nuclear size , 2009, Magnetic resonance in medicine.

[36]  Michael C. Kolios,et al.  Quantitative Ultrasound Characterization of Responses to Radiotherapy in Cancer Mouse Models , 2009, Clinical Cancer Research.

[37]  Michael C. Kolios,et al.  Monitoring of cell death in epithelial cells using high frequency ultrasound spectroscopy. , 2009, Ultrasound in medicine & biology.

[38]  S. Stone-Elander,et al.  On the Selection of a Tracer for PET Imaging of HER2-Expressing Tumors: Direct Comparison of a 124I-Labeled Affibody Molecule and Trastuzumab in a Murine Xenograft Model , 2009, Journal of Nuclear Medicine.

[39]  Lihong V. Wang,et al.  Noninvasive, in vivo imaging of blood-oxygenation dynamics within the mouse brain using photoacoustic microscopy. , 2009, Journal of biomedical optics.

[40]  Azeem Saleem,et al.  Early Tumor Drug Pharmacokinetics Is Influenced by Tumor Perfusion but not Plasma Drug Exposure , 2008, Clinical Cancer Research.

[41]  Michael C. Kolios,et al.  Quantitative ultrasound characterization of cancer radiotherapy effects in vitro. , 2008, International journal of radiation oncology, biology, physics.

[42]  Lucy E Kershaw,et al.  Cellular‐interstitial water exchange and its effect on the determination of contrast agent concentration in vivo: Dynamic contrast‐enhanced MRI of human internal obturator muscle , 2008, Magnetic resonance in medicine.

[43]  Michael C. Kolios,et al.  Ultrasound imaging of apoptosis in tumor response: novel preclinical monitoring of photodynamic therapy effects. , 2008, Cancer research.

[44]  Hai-Ling Margaret Cheng,et al.  Investigation and optimization of parameter accuracy in dynamic contrast‐enhanced MRI , 2008, Journal of magnetic resonance imaging : JMRI.

[45]  W. Wagner,et al.  Ultrasound molecular imaging of cardiovascular disease , 2008, Nature Clinical Practice Cardiovascular Medicine.

[46]  S. Michaeli,et al.  Water spin dynamics during apoptotic cell death in glioma gene therapy probed by T1ρ and T2ρ , 2008, Magnetic resonance in medicine.

[47]  Jinyuan Zhou,et al.  Amide proton transfer imaging of 9L gliosarcoma and human glioblastoma xenografts , 2008, NMR in biomedicine.

[48]  G. Hortobagyi,et al.  Can early response assessment guide neoadjuvant chemotherapy in early-stage breast cancer? , 2008, Journal of the National Cancer Institute.

[49]  P. Vrignaud,et al.  Early Quantitative Evaluation of a Tumor Vasculature Disruptive Agent AVE8062 Using Dynamic Contrast-Enhanced Ultrasonography , 2008, Investigative radiology.

[50]  Kevin Brindle,et al.  New approaches for imaging tumour responses to treatment , 2008, Nature Reviews Cancer.

[51]  S T Elliott.  Volume ultrasound: the next big thing? , 2008, The British journal of radiology.

[52]  A. Darzi,et al.  Diffuse optical imaging of the healthy and diseased breast: A systematic review , 2008, Breast Cancer Research and Treatment.

[53]  A. Connolly,et al.  Sensitive Ultrasonic Delineation of Steroid Treatment in Living Dystrophic Mice with Energy-Based and Entropy-Based Radio Frequency Signal Processing , 2007, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[54]  Linda Chami,et al.  Dynamic contrast-enhanced ultrasonography (DCE-US) with quantification of tumor perfusion: a new diagnostic tool to evaluate the early effects of antiangiogenic treatment , 2007, European radiology.

[55]  Paul A Dayton,et al.  Molecular ultrasound imaging using microbubble contrast agents. , 2007, Frontiers in bioscience : a journal and virtual library.

[56]  B. Tromberg,et al.  Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy. , 2007, Journal of biomedical optics.

[57]  J. Vonesch,et al.  Quantitative ultrasonic tissue characterization as a new tool for continuous monitoring of chronic liver remodelling in mice , 2007 .

[58]  Monica Morrow,et al.  Local therapy and survival in breast cancer. , 2007, The New England journal of medicine.

[59]  Mark R Holland,et al.  Characterization of Anisotropic Myocardial Backscatter Using Spectral Slope, Intercept and Midband Fit Parameters , 2007, Ultrasonic imaging.

[60]  P. Gionchetti,et al.  Ultrasound assessment of vascularization of the thickened terminal ileum wall in Crohn's disease patients using a low-mechanical index real-time scanning technique with a second generation ultrasound contrast agent. , 2007, European journal of radiology.

[61]  L. Abrahmsén,et al.  Affibody molecules: potential for in vivo imaging of molecular targets for cancer therapy , 2007, Expert opinion on biological therapy.

[62]  B. Tromberg,et al.  Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopy , 2007, Proceedings of the National Academy of Sciences.

[63]  Michael C. Kolios,et al.  Ultrasonic characterization of whole cells and isolated nuclei. , 2007, Ultrasound in medicine & biology.

[64]  Johan Bussink,et al.  Dynamics of Tumor Hypoxia Measured with Bioreductive Hypoxic Cell Markers , 2007, Radiation research.

[65]  Evis Sala,et al.  Dynamic contrast-enhanced MRI as a predictor of tumour response to radiotherapy. , 2007, The Lancet. Oncology.

[66]  N. de Jong,et al.  P2A-3 High Frequency Attenuation and Size Distribution Measurements of Definity and Manipulated Definity Populations , 2006, 2006 IEEE Ultrasonics Symposium.

[67]  D. Hunting,et al.  PET imaging of apoptosis with 64Cu-labeled streptavidin following pretargeting of phosphatidylserine with biotinylated annexin-V , 2007, European Journal of Nuclear Medicine and Molecular Imaging.

[68]  D. Boas,et al.  Diffuse optical tomography system to image brain activation with improved spatial resolution and validation with functional magnetic resonance imaging. , 2006, Applied optics.

[69]  Geoff J M Parker,et al.  Comparison of errors associated with single‐ and multi‐bolus injection protocols in low‐temporal‐resolution dynamic contrast‐enhanced tracer kinetic analysis , 2006, Magnetic resonance in medicine.

[70]  K. Ishiwata,et al.  Early response of sigma-receptor ligands and metabolic PET tracers to 3 forms of chemotherapy: an in vitro study in glioma cells. , 2006, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[71]  Hyuing Zhang,et al.  Characterization of digital waveforms using thermodynamic analogs: detection of contrast-targeted tissue in vivo , 2006, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[72]  D. Mankoff,et al.  Quantitative fluoroestradiol positron emission tomography imaging predicts response to endocrine treatment in breast cancer. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[73]  Xiaoping Zhou,et al.  A new formalism for the quantification of tissue perfusion by the destruction-replenishment method in contrast ultrasound imaging , 2006, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[74]  J. Carlsson,et al.  Tumor imaging using a picomolar affinity HER2 binding affibody molecule. , 2006, Cancer research.

[75]  J. Gore,et al.  Correlation Between Estimates of Tumor Perfusion From Microbubble Contrast‐Enhanced Sonography and Dynamic Contrast‐Enhanced Magnetic Resonance Imaging , 2006, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.

[76]  T. Livraghi,et al.  Radiofrequency Ablation of Liver Tumors: The Role of Microbubble Ultrasound Contrast Agents , 2006, Ultrasound quarterly.

[77]  Geng Ku,et al.  Noninvasive imaging of hemoglobin concentration and oxygenation in the rat brain using high-resolution photoacoustic tomography. , 2006, Journal of biomedical optics.

[78]  R. Collins,et al.  Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials , 2005, The Lancet.

[79]  M. Eble,et al.  [18F] fluoromisonidazole and [18F] fluorodeoxyglucose positron emission tomography in response evaluation after chemo-/radiotherapy of non-small-cell lung cancer: a feasibility study , 2006, BMC Cancer.

[80]  B. Tromberg,et al.  Imaging in breast cancer: Diffuse optics in breast cancer: detecting tumors in pre-menopausal women and monitoring neoadjuvant chemotherapy , 2005, Breast Cancer Research.

[81]  J. H. Lim,et al.  Therapeutic response assessment of percutaneous radiofrequency ablation for hepatocellular carcinoma: utility of contrast-enhanced agent detection imaging. , 2005, European journal of radiology.

[82]  J W Hunt,et al.  Monitoring structural changes in cells with high-frequency ultrasound signal statistics. , 2005, Ultrasound in medicine & biology.

[83]  K. Ogan,et al.  Monitoring radiofrequency renal lesions in real time using contrast-enhanced ultrasonography: a porcine model. , 2005, Journal of endourology.

[84]  Wiendelt Steenbergen,et al.  The Twente Photoacoustic Mammoscope: system overview and performance , 2005, Physics in medicine and biology.

[85]  Soren D. Konecky,et al.  Diffuse optical tomography of breast cancer during neoadjuvant chemotherapy: a case study with comparison to MRI. , 2005, Medical physics.

[86]  Dianne Georgian-Smith,et al.  Prospective comparison of mammography, sonography, and MRI in patients undergoing neoadjuvant chemotherapy for palpable breast cancer. , 2005, AJR. American journal of roentgenology.

[87]  C. Dence,et al.  Positron tomographic assessment of androgen receptors in prostatic carcinoma , 2005, European Journal of Nuclear Medicine and Molecular Imaging.

[88]  R. Eckersley,et al.  Optimising phase and amplitude modulation schemes for imaging microbubble contrast agents at low acoustic power. , 2005, Ultrasound in medicine & biology.

[89]  Matthias Reimold,et al.  Prognostic impact of hypoxia imaging with 18F-misonidazole PET in non-small cell lung cancer and head and neck cancer before radiotherapy. , 2005, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[90]  Michael C. Kolios,et al.  High-frequency ultrasound for monitoring changes in liver tissue during preservation , 2005, Physics in medicine and biology.

[91]  Jonathan Mamou,et al.  Identifying ultrasonic scattering sites from three-dimensional impedance maps. , 2005, The Journal of the Acoustical Society of America.

[92]  Michael E. Phelps,et al.  Usefulness of 3′-[F-18]Fluoro-3′-deoxythymidine with Positron Emission Tomography in Predicting Breast Cancer Response to Therapy , 2005, Molecular Imaging and Biology.

[93]  S. Delorme,et al.  Monitoring of liver metastases after stereotactic radiotherapy using low-MI contrast-enhanced ultrasound—initial results , 2005, European Radiology.

[94]  Anders M. Dale,et al.  Diffuse optical imaging of brain activation: approaches to optimizing image sensitivity, resolution, and accuracy , 2004, NeuroImage.

[95]  C. Wiele,et al.  Receptor Imaging in Oncology by Means of Nuclear Medicine: Current Status , 2004 .

[96]  James G. Miller,et al.  Ultrasonic tissue characterization of the mouse myocardium: successful in vivo cyclic variation measurements. , 2004, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[97]  J. Detre,et al.  Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation. , 2004, Optics letters.

[98]  Peter Vaupel,et al.  Tumor microenvironmental physiology and its implications for radiation oncology. , 2004, Seminars in radiation oncology.

[99]  William D. O'Brien,et al.  Differentiation and characterization of rat mammary fibroadenomas and 4T1 mouse carcinomas using quantitative ultrasound imaging , 2004, IEEE Transactions on Medical Imaging.

[100]  R. Kauppinen,et al.  Water diffusion in a rat glioma during ganciclovir‐thymidine kinase gene therapy‐induced programmed cell death in vivo: Correlation with cell density , 2004, Journal of magnetic resonance imaging : JMRI.

[101]  Jonathan R Lindner,et al.  Molecular imaging with contrast ultrasound and targeted microbubbles , 2004, Journal of Nuclear Cardiology.

[102]  B. Tromberg,et al.  Monitoring neoadjuvant chemotherapy in breast cancer using quantitative diffuse optical spectroscopy: a case study. , 2004, Journal of biomedical optics.

[103]  S. Giordano,et al.  Update on locally advanced breast cancer. , 2003, The oncologist.

[104]  R. Kauppinen,et al.  Novel magnetic resonance imaging contrasts for monitoring response to gene therapy in rat glioma. , 2003, Cancer research.

[105]  D. Boas,et al.  Volumetric diffuse optical tomography of brain activity. , 2003, Optics letters.

[106]  M. Schwaiger,et al.  Positron emission tomography in non-small-cell lung cancer: prediction of response to chemotherapy by quantitative assessment of glucose use. , 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[107]  David A Boas,et al.  Temporal comparison of functional brain imaging with diffuse optical tomography and fMRI during rat forepaw stimulation , 2003, Physics in medicine and biology.

[108]  Turgut Durduran,et al.  Diffuse optical measurement of hemoglobin and cerebral blood flow in rat brain during hypercapnia, hypoxia and cardiac arrest. , 2003, Advances in experimental medicine and biology.

[109]  Roland Hustinx,et al.  Increased uptake of the apoptosis-imaging agent (99m)Tc recombinant human Annexin V in human tumors after one course of chemotherapy as a predictor of tumor response and patient prognosis. , 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.

[110]  S. Gambhir.  Molecular imaging of cancer with positron emission tomography , 2002, Nature Reviews Cancer.

[111]  Henry M Kuerer,et al.  Locoregional treatment outcomes for inoperable anthracycline-resistant breast cancer. , 2002, International journal of radiation oncology, biology, physics.

[112]  Michael C. Kolios,et al.  Ultrasonic spectral parameter characterization of apoptosis. , 2002, Ultrasound in medicine & biology.

[113]  Jiri Sklenar,et al.  Microvascular rheology of Definity microbubbles after intra-arterial and intravenous administration. , 2002, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[114]  Seppo Ylä-Herttuala,et al.  Early gene therapy–induced apoptotic response in BT4C gliomas by magnetic resonance relaxation contrast T1 in the rotating frame , 2002, Cancer Gene Therapy.

[115]  Fiona J Gilbert,et al.  Neoadjuvant chemotherapy in breast cancer: significantly enhanced response with docetaxel. , 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[116]  Michael E Phelps,et al.  Positron emission tomography scanning: current and future applications. , 2002, Annual review of medicine.

[117]  Albert Cerussi,et al.  Noninvasive functional optical spectroscopy of human breast tissue , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[118]  P. Dupont,et al.  Prognostic value of positron emission tomography (PET) with fluorine-18 fluorodeoxyglucose ([18F]FDG) after first-line chemotherapy in non-Hodgkin's lymphoma: is [18F]FDG-PET a valid alternative to conventional diagnostic methods? , 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[119]  T. Smith,et al.  The rate-limiting step for tumor [18F]fluoro-2-deoxy-D-glucose (FDG) incorporation. , 2001, Nuclear medicine and biology.

[120]  Britton Chance,et al.  Breast imaging technology: Probing physiology and molecular function using optical imaging - applications to breast cancer , 2000, Breast Cancer Research.

[121]  J. Gorce,et al.  Influence of Bubble Size Distribution on the Echogenicity of Ultrasound Contrast Agents: A Study of SonoVue™ , 2000, Investigative radiology.

[122]  T. Ogihara,et al.  Quantitative ultrasonic tissue characterization can identify high-risk atherosclerotic alteration in human carotid arteries. , 2000, Circulation.

[123]  J. Nährig,et al.  Positron emission tomography using [(18)F]Fluorodeoxyglucose for monitoring primary chemotherapy in breast cancer. , 2000, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[124]  L. Svaasand,et al.  Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy. , 2000, Neoplasia.

[125]  D. A. Christopher,et al.  Advances in ultrasound biomicroscopy. , 2000, Ultrasound in medicine & biology.

[126]  G. Zonios,et al.  Diffuse reflectance spectroscopy of human adenomatous colon polyps in vivo. , 1999, Applied optics.

[127]  J W Hunt,et al.  © 1999 Cancer Research Campaign Article no. bjoc.1999.0724 Ultrasound imaging of apoptosis: high-resolution noninvasive , 2022 .

[128]  Xin Li,et al.  Equilibrium transcytolemmal water‐exchange kinetics in skeletal muscle in vivo , 1999, Magnetic resonance in medicine.

[129]  D. Mankoff,et al.  Monitoring the response of patients with locally advanced breast carcinoma to neoadjuvant chemotherapy using [technetium 99m]‐sestamibi scintimammography , 1999, Cancer.

[130]  T K Lewellen,et al.  Carbon-11-thymidine and FDG to measure therapy response. , 1998, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[131]  Anna L. Brown,et al.  Effect of preoperative chemotherapy on the outcome of women with operable breast cancer. , 1998, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[132]  A R Jayaweera,et al.  Quantification of myocardial blood flow with ultrasound-induced destruction of microbubbles administered as a constant venous infusion. , 1998, Circulation.

[133]  Michael Molls,et al.  Blood perfusion and microenvironment of human tumors : implications for clinical radiooncology , 1998 .

[134]  T L Chenevert,et al.  Monitoring early response of experimental brain tumors to therapy using diffusion magnetic resonance imaging. , 1997, Clinical cancer research : an official journal of the American Association for Cancer Research.

[135]  S Charrier,et al.  Clinical and pathological response to primary chemotherapy in operable breast cancer. , 1997, European journal of cancer.

[136]  Michael C. Kolios,et al.  Ultrasonic biomicroscopy of viable, dead and apoptotic cells. , 1997, Ultrasound in medicine & biology.

[137]  G. Hortobagyi,et al.  Locally advanced breast cancer. , 1999, Hematology/oncology clinics of North America.

[138]  B R Rosen,et al.  Improving MR quantification of regional blood volume with intravascular T1 contrast agents: Accuracy, precision, and water exchange , 1996, Magnetic resonance in medicine.

[139]  G. Hortobagyi,et al.  Comprehensive management of locally advanced breast cancer , 1990, Cancer.

[140]  K. Hynynen,et al.  The effect of blood perfusion rate on the temperature distributions induced by multiple, scanned and focused ultrasonic beams in dogs' kidneys in vivo. , 1989, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[141]  J. G. Miller,et al.  Quantitative ultrasonic tissue characterization with real-time integrated backscatter imaging in normal human subjects and in patients with dilated cardiomyopathy. , 1987, Circulation.

[142]  D. Paulus.  Imaging in breast cancer , 1987, CA: a cancer journal for clinicians.