Beyond self-eating: The control of nonautophagic functions and signaling pathways by autophagy-related proteins

Cadwell and Debnath provide a perspective on our emerging understanding of the nonautophagic functions of autophagy-related proteins and their role in disease.

[1]  Vanessa M. Hubbard-Lucey,et al.  Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium , 2017, The Journal of experimental medicine.

[2]  R. Xavier,et al.  Paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine , 2017, Science.

[3]  Masahiro Yamamoto,et al.  Viral Replication Complexes Are Targeted by LC3-Guided Interferon-Inducible GTPases. , 2017, Cell host & microbe.

[4]  J. Debnath,et al.  Autophagy-Dependent Shuttling of TBC1D5 Controls Plasma Membrane Translocation of GLUT1 and Glucose Uptake. , 2017, Molecular cell.

[5]  L. Boon,et al.  Tregs restrain dendritic cell autophagy to ameliorate autoimmunity , 2017, The Journal of clinical investigation.

[6]  O. Nureki,et al.  Cyclic GMP-AMP as an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA. , 2017, Annual review of biochemistry.

[7]  Shih-Cheng Chang,et al.  Inhibition of Avian Influenza A Virus Replication in Human Cells by Host Restriction Factor TUFM Is Correlated with Autophagy , 2017, mBio.

[8]  S. Akira,et al.  Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense , 2017, Nature Immunology.

[9]  Mingzhou Chen,et al.  The Matrix Protein of Human Parainfluenza Virus Type 3 Induces Mitophagy that Suppresses Interferon Responses. , 2017, Cell host & microbe.

[10]  R. Xavier,et al.  Genetic control of autophagy underlies pathogenesis of inflammatory bowel disease , 2017, Mucosal Immunology.

[11]  M. Parkes,et al.  Defective ATG16L1-mediated removal of IRE1α drives Crohn’s disease–like ileitis , 2017, The Journal of experimental medicine.

[12]  C. Coyne,et al.  Dengue and Zika viruses subvert reticulophagy by NS2B3-mediated cleavage of FAM134B , 2017, Autophagy.

[13]  Anne K. Braczynski,et al.  IKKα controls ATG16L1 degradation to prevent ER stress during inflammation , 2017, The Journal of experimental medicine.

[14]  K. Lidke,et al.  Dedicated SNAREs and specialized TRIM cargo receptors mediate secretory autophagy , 2017, The EMBO journal.

[15]  Masato Koike,et al.  The ATG conjugation systems are important for degradation of the inner autophagosomal membrane , 2016, Science.

[16]  K. Cadwell Crosstalk between autophagy and inflammatory signalling pathways: balancing defence and homeostasis , 2016, Nature Reviews Immunology.

[17]  Zhijian J. Chen,et al.  Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing , 2016, Nature Immunology.

[18]  Wienand A. Omta,et al.  An siRNA screen for ATG protein depletion reveals the extent of the unconventional functions of the autophagy proteome in virus replication , 2016, The Journal of cell biology.

[19]  J. Carpenter,et al.  Exocytosis of Varicella-Zoster Virus Virions Involves a Convergence of Endosomal and Autophagy Pathways , 2016, Journal of Virology.

[20]  T. Kanneganti,et al.  The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation , 2016, The Journal of cell biology.

[21]  R. Xavier,et al.  The T300A Crohn's disease risk polymorphism impairs function of the WD40 domain of ATG16L1 , 2016, Nature Communications.

[22]  R. Xavier,et al.  Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease , 2016, Science.

[23]  Seungmin Hwang,et al.  Targeting by AutophaGy proteins (TAG): Targeting of IFNG-inducible GTPases to membranes by the LC3 conjugation system of autophagy , 2016, Autophagy.

[24]  D. Green,et al.  Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells , 2016, Nature.

[25]  Mark Ellisman,et al.  NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria , 2016, Cell.

[26]  Q. Sattentau,et al.  The autophagy gene Atg16l1 differentially regulates Treg and TH2 cells to control intestinal inflammation , 2016, eLife.

[27]  Maxim N. Artyomov,et al.  Homeostatic Control of Innate Lung Inflammation by Vici Syndrome Gene Epg5 and Additional Autophagy Genes Promotes Influenza Pathogenesis. , 2016, Cell host & microbe.

[28]  Maxim N. Artyomov,et al.  Autophagy Genes Enhance Murine Gammaherpesvirus 68 Reactivation from Latency by Preventing Virus-Induced Systemic Inflammation , 2016, Cell Host & Microbe.

[29]  S. Muller,et al.  Autophagy is dispensable for B-cell development but essential for humoral autoimmune responses , 2015, Cell Death and Differentiation.

[30]  J. Debnath,et al.  Unique role for ATG5 in PMN-mediated immunopathology during M. tuberculosis infection , 2015, Nature.

[31]  R. Schekman,et al.  Translocation of interleukin-1β into a vesicle intermediate in autophagy-mediated secretion , 2015, eLife.

[32]  J. Debnath,et al.  Autophagy at the crossroads of catabolism and anabolism , 2015, Nature Reviews Molecular Cell Biology.

[33]  J. Kearney,et al.  B cell autophagy mediates TLR7-dependent autoimmunity and inflammation , 2015, Autophagy.

[34]  D. Green,et al.  Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins , 2015, Nature Cell Biology.

[35]  L. Kuai,et al.  Requirement for Autophagy in the Long-Term Persistence but not Initial Formation of Memory B cells , 2015, The Journal of Immunology.

[36]  E. Wimmer,et al.  Phosphatidylserine Vesicles Enable Efficient En Bloc Transmission of Enteroviruses , 2015, Cell.

[37]  I. Dikic,et al.  PLEKHM1 regulates autophagosome-lysosome fusion through HOPS complex and LC3/GABARAP proteins. , 2015, Molecular cell.

[38]  V. Malhotra,et al.  Remodeling of secretory compartments creates CUPS during nutrient starvation , 2014, The Journal of cell biology.

[39]  J. Dengjel,et al.  Macroautophagy Proteins Assist Epstein Barr Virus Production and Get Incorporated Into the Virus Particles , 2014, EBioMedicine.

[40]  K. Cadwell,et al.  An enteric virus can replace the beneficial function of commensal bacteria , 2014, Nature.

[41]  Vanessa M. Hubbard-Lucey,et al.  Autophagy gene Atg16L1 prevents lethal T cell alloreactivity mediated by dendritic cells. , 2014, Immunity.

[42]  C. Théry,et al.  Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. , 2014, Annual review of cell and developmental biology.

[43]  Sara W. Bird,et al.  Nonlytic viral spread enhanced by autophagy components , 2014, Proceedings of the National Academy of Sciences.

[44]  S. Akira,et al.  The parasitophorous vacuole membrane of Toxoplasma gondii is targeted for disruption by ubiquitin-like conjugation systems of autophagy. , 2014, Immunity.

[45]  A. Ernst,et al.  Cargo recognition and trafficking in selective autophagy , 2014, Nature Cell Biology.

[46]  D. Bumann,et al.  Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases , 2014, Nature.

[47]  Jacob D. Jaffe,et al.  Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense , 2014, Proceedings of the National Academy of Sciences.

[48]  D. Corry,et al.  Essential Role for Autophagy in the Maintenance of Immunological Memory Against Influenza Infection , 2014, Nature Medicine.

[49]  J. DeVoss,et al.  A Crohn’s disease variant in Atg16l1 enhances its degradation by caspase 3 , 2014, Nature.

[50]  F. Randow,et al.  A LC3-Interacting Motif in the Influenza A Virus M2 Protein Is Required to Subvert Autophagy and Maintain Virion Stability , 2014, Cell host & microbe.

[51]  B. Oh,et al.  Crosstalk between the cGAS DNA sensor and Beclin-1 autophagy protein shapes innate antimicrobial immune responses. , 2014, Cell host & microbe.

[52]  C. Kenific,et al.  Autophagy-dependent production of secreted factors facilitates oncogenic RAS-driven invasion. , 2014, Cancer discovery.

[53]  J. Mercera,et al.  Atg 16 L 1 T 300 A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense Citation , 2014 .

[54]  Hiroyuki Miyoshi,et al.  Autophagy proteins control goblet cell function by potentiating reactive oxygen species production , 2013, The EMBO journal.

[55]  J. Dengjel,et al.  Autophagy proteins stabilize pathogen-containing phagosomes for prolonged MHC II antigen processing , 2013, The Journal of cell biology.

[56]  R. Xavier,et al.  Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection. , 2013, Gastroenterology.

[57]  G. Barber,et al.  Cyclic Dinucleotides Trigger ULK1 (ATG1) Phosphorylation of STING to Prevent Sustained Innate Immune Signaling , 2013, Cell.

[58]  D. Green,et al.  Noncanonical Autophagy Promotes the Visual Cycle , 2013, Cell.

[59]  A. Kaser,et al.  Paneth cells as a site of origin for intestinal inflammation , 2013, Nature.

[60]  Vanessa M. Hubbard-Lucey,et al.  A deficiency in the autophagy gene Atg16L1 enhances resistance to enteric bacterial infection. , 2013, Cell host & microbe.

[61]  V. Malhotra Unconventional protein secretion: an evolving mechanism , 2013, The EMBO journal.

[62]  R. Sumpter,et al.  Intestinal epithelial autophagy is essential for host defense against invasive bacteria. , 2013, Cell host & microbe.

[63]  R. Schekman,et al.  Unconventional Secretion, Unconventional Solutions , 2013, Science.

[64]  J. Tavaré,et al.  A global analysis of SNX27–retromer assembly and cargo specificity reveals a function in glucose and metal ion transport , 2013, Nature Cell Biology.

[65]  Zhijian J. Chen,et al.  Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway , 2013, Science.

[66]  S. Casola,et al.  Plasma cells require autophagy for sustainable immunoglobulin production , 2013, Nature Immunology.

[67]  V. Malhotra,et al.  Non-autophagic roles of autophagy-related proteins , 2013, EMBO reports.

[68]  R. Xavier,et al.  ATG5 regulates plasma cell differentiation , 2013, Autophagy.

[69]  S. Ryter,et al.  Autophagy in human health and disease. , 2013, The New England journal of medicine.

[70]  D. Green,et al.  Noncanonical autophagy is required for type I interferon secretion in response to DNA-immune complexes. , 2012, Immunity.

[71]  T. Tang,et al.  COX5B Regulates MAVS-mediated Antiviral Signaling through Interaction with ATG5 and Repressing ROS Production , 2012, PLoS pathogens.

[72]  V. Malhotra,et al.  Diversity in unconventional protein secretion , 2012, Journal of Cell Science.

[73]  V. Deretic,et al.  Autophagy intersections with conventional and unconventional secretion in tissue development, remodeling and inflammation. , 2012, Trends in cell biology.

[74]  Xian Chen,et al.  The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy. , 2012, Immunity.

[75]  M. Alirezaei,et al.  Pancreatic acinar cell-specific autophagy disruption reduces coxsackievirus replication and pathogenesis in vivo. , 2012, Cell host & microbe.

[76]  C. López-Otín,et al.  Selective subversion of autophagy complexes facilitates completion of the Brucella intracellular cycle. , 2012, Cell host & microbe.

[77]  P. Codogno,et al.  Canonical and non-canonical autophagy: variations on a common theme of self-eating? , 2011, Nature Reviews Molecular Cell Biology.

[78]  E. Unanue,et al.  Autophagy in antigen-presenting cells results in presentation of citrullinated peptides to CD4 T cells , 2011, The Journal of experimental medicine.

[79]  V. Deretic,et al.  Autophagy‐based unconventional secretory pathway for extracellular delivery of IL‐1β , 2011, The EMBO journal.

[80]  H. Virgin,et al.  Autophagy proteins regulate the secretory component of osteoclastic bone resorption. , 2011, Developmental cell.

[81]  Cole M. Haynes,et al.  Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes , 2011, Nature Cell Biology.

[82]  N. Mizushima,et al.  The role of Atg proteins in autophagosome formation. , 2011, Annual review of cell and developmental biology.

[83]  D. Green,et al.  Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells , 2011, Proceedings of the National Academy of Sciences.

[84]  Min Goo Lee,et al.  Rescue of ΔF508-CFTR Trafficking via a GRASP-Dependent Unconventional Secretion Pathway , 2011, Cell.

[85]  Simon Tavaré,et al.  Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes , 2011, Science.

[86]  R. Xavier,et al.  Virus-Plus-Susceptibility Gene Interaction Determines Crohn's Disease Gene Atg16L1 Phenotypes in Intestine , 2010, Cell.

[87]  Fulvio Reggiori,et al.  Coronaviruses Hijack the LC3-I-Positive EDEMosomes, ER-Derived Vesicles Exporting Short-Lived ERAD Regulators, for Replication , 2010, Cell Host & Microbe.

[88]  C. Anjard,et al.  Unconventional secretion of Pichia pastoris Acb1 is dependent on GRASP protein, peroxisomal functions, and autophagosome formation , 2010, The Journal of cell biology.

[89]  C. Anjard,et al.  Unconventional secretion of Acb1 is mediated by autophagosomes , 2010, The Journal of cell biology.

[90]  K. Ishii,et al.  Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response , 2009, Proceedings of the National Academy of Sciences.

[91]  R. Albrecht,et al.  Matrix protein 2 of influenza A virus blocks autophagosome fusion with lysosomes. , 2009, Cell host & microbe.

[92]  V. Deretic,et al.  Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages , 2009, The Journal of cell biology.

[93]  V. Deretic,et al.  Autophagy, immunity, and microbial adaptations. , 2009, Cell host & microbe.

[94]  K. Kirkegaard,et al.  Role of Microtubules in Extracellular Release of Poliovirus , 2009, Journal of Virology.

[95]  Veronica Canadien,et al.  Activation of antibacterial autophagy by NADPH oxidases , 2009, Proceedings of the National Academy of Sciences.

[96]  A. Iwasaki,et al.  Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling , 2009, Proceedings of the National Academy of Sciences.

[97]  Sarah L. Brown,et al.  A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells , 2008, Nature.

[98]  J. Satsangi Faculty Opinions recommendation of Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. , 2008 .

[99]  B. McManus,et al.  Autophagosome Supports Coxsackievirus B3 Replication in Host Cells , 2008, Journal of Virology.

[100]  Marta E Alarcón-Riquelme,et al.  Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci , 2008, Nature Genetics.

[101]  D. Green,et al.  Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis , 2007, Nature.

[102]  A. Miyawaki,et al.  The Atg5–Atg12 conjugate associates with innate antiviral immune responses , 2007, Proceedings of the National Academy of Sciences.

[103]  M. Pypaert,et al.  Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomes. , 2007, Immunity.

[104]  Ralf Bartenschlager,et al.  Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus , 2005, Nature.

[105]  Osamu Takeuchi,et al.  IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction , 2005, Nature Immunology.

[106]  Zhijian J. Chen,et al.  Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3 , 2005, Cell.

[107]  H. Rammensee,et al.  Autophagy promotes MHC class II presentation of peptides from intracellular source proteins , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[108]  K. Kirkegaard,et al.  Subversion of Cellular Autophagosomal Machinery by RNA Viruses , 2005, PLoS biology.

[109]  Hideo Negishi,et al.  IRF-7 is the master regulator of type-I interferon-dependent immune responses , 2005, Nature.

[110]  Zhijian J. Chen,et al.  Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. , 2005, Cell.

[111]  Shizuo Akira,et al.  The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses , 2004, Nature Immunology.

[112]  D. Klionsky,et al.  Genetic and Phenotypic Overlap between Autophagy and the Cytoplasm to Vacuole Protein Targeting Pathway* , 1996, The Journal of Biological Chemistry.

[113]  M. Schlumpberger,et al.  Isolation of autophagocytosis mutants of Saccharomyces cerevisiae , 1994, FEBS letters.

[114]  Y. Ohsumi,et al.  Isolation and characterization of autophagy‐defective mutants of Saccharomyces cerevisiae , 1993, FEBS letters.

[115]  S. Tsuboi,et al.  Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its induction , 1992, The Journal of cell biology.

[116]  J. Mitchison Cell Biology , 1964, Nature.