The adverse impact of chlorofluorocarbons (CFCs) on stratospheric ozone has prompted an international effort for replacement with environmentally acceptable alternatives such as hydrogen-containing chlorofluorocarbons (HCFCs). Previous studies of the reactions of OH and HCFC were limited to 298 K or below. Rate coefficients are needed above 480 K to verify the existing theoretical interpretations. Kinetics study of OH and HCFC reactions over an extended temperature range is revealed by LP/LIF technique. Based on the experimental data, the conventional transition state theory with the assistance of ab initio calculations is used to predict the reactions above 2000 K. A methodology is evolved from the precision measurements and the reliable theoretical studies.