Arrhythmia detection based on time–frequency features of heart rate variability and back-propagation neural network

This paper presents a novel method for detection of arrhythmia using adaptive continuous Morlet wavelet transform and back-propagation neural network. The detection is based on extracted features in Time–Frequency (T–F) domain from heart rate variability (HRV) signals. For this, HRV signal is segmented into small length (48 inter beat interval). The T–F analysis methods, namely, adaptive continuous Morlet wavelet transform (ACMWT), adaptive modified Stockwell transform (AMST), and adaptive Stockwell transform (AST), are employed for features’ extraction. The adaptations of these methods are established on energy concentration. The features such as Flatness, flux, Skewness, Kurtosis, Shannon entropy, Renyi entropy, and coefficient of variation are extracted by T–F analysis methods from segmented HRV signals. These features are applied to back-propagation neural network for training and validation of neural networks. The outputs of neural network are applied to three different decision rules as average, vote, and decision vote. The proposed method is validated using the standard database of arrhythmic subjects. Simulated results show that features extracted by ACMWT from HRV signals achieved accuracy (AC) of 95.98%, specificity (SP) of 96.24%, and sensitivity (SE) of 89.5% for low-frequency (LF) band, and AC of 97.13%, SP of 96.13% and SE of 94.38% for high-frequency (HF) band of HRV signal when using decision vote rule. The results achieved by ACMWT are better than AST and AMST.

[1]  Ljubisa Stankovic,et al.  Highly concentrated time-frequency distributions: pseudo quantum signal representation , 1997, IEEE Trans. Signal Process..

[2]  Ingrid Daubechies,et al.  Ten Lectures on Wavelets , 1992 .

[3]  AzemiGhasem,et al.  Principles of time-frequency feature extraction for change detection in non-stationary signals , 2015 .

[4]  Mark D. Huffman,et al.  Executive summary: heart disease and stroke statistics--2013 update: a report from the American Heart Association. , 2013, Circulation.

[5]  Douglas L. Jones,et al.  A high resolution data-adaptive time-frequency representation , 1990, IEEE Trans. Acoust. Speech Signal Process..

[6]  N. Thakor,et al.  Ventricular tachycardia and fibrillation detection by a sequential hypothesis testing algorithm , 1990, IEEE Transactions on Biomedical Engineering.

[7]  M. L. Soria,et al.  Signal processing for automatic heartbeat classification and patient adaptation in the electrocardiogram , 2013 .

[8]  X. Wu,et al.  Predicting coronary disease risk based on short-term RR interval measurements: a neural network approach , 1999, Artif. Intell. Medicine.

[9]  Marek Malik,et al.  Time-Domain Measurement of Heart Rate Variability , 1997 .

[10]  Jin Jiang,et al.  Frequency-based window width optimization for S-transform , 2008 .

[11]  N. Shenbagavadivu,et al.  Performance Analysis Of Various Machine Learning Techniques To Predict Cardiovascular Disease: An Emprical Study , 2018 .

[12]  Boualem Boashash,et al.  Time-frequency features for pattern recognition using high-resolution TFDs: A tutorial review , 2015, Digit. Signal Process..

[13]  A. Luna Nueva terminología de las paredes del corazón y nueva clasificación electrocardiográfica de los infartos con onda Q basada en la correlación con la resonancia magnética , 2007 .

[14]  R. Cohen,et al.  Power spectrum analysis of heart rate fluctuation: a quantitative probe of beat-to-beat cardiovascular control. , 1981, Science.

[15]  S. Cerutti,et al.  Spectral analysis of heart rate variability signal and respiration in diabetic subjects , 1990, Medical and Biological Engineering and Computing.

[16]  I. Jacobs,et al.  A review of pre‐hospital defibrillation by ambulance officers in Perth, Western Australia , 1990, The Medical journal of Australia.

[17]  C. Bigan,et al.  Time-frequency analysis of short segments of biomedical data , 2000 .

[18]  A. Luna,et al.  Clinical Electrocardiography: A Textbook , 1993 .

[19]  A. Upton,et al.  Air Pollution and Cardiovascular Disease: A Review. , 2016, Critical reviews in biomedical engineering.

[20]  Ary L. Goldberger Basic ECG Waves , 2006 .

[21]  B. S. Saini,et al.  Times Varying Spectral Coherence Investigation of Cardiovascular Signals Based on Energy Concentration in Healthy Young and Elderly Subjects by the Adaptive Continuous Morlet Wavelet Transform , 2018 .

[22]  Douglas P. Zipes,et al.  Clinical Arrhythmology and Electrophysiology: A Companion to Braunwald's Heart Disease , 2012 .

[23]  Mostefa Mesbah,et al.  Time-Frequency Analysis of Heart Rate Variability for Neonatal Seizure Detection , 2007, EURASIP J. Adv. Signal Process..

[24]  H. Chan,et al.  Time-frequency spectral analysis of heart rate variability during induction of general anaesthesia. , 1997, British journal of anaesthesia.

[25]  Irena Orovic,et al.  A Virtual Instrument for Time-Frequency Analysis of Signals With Highly Nonstationary Instantaneous Frequency , 2011, IEEE Transactions on Instrumentation and Measurement.

[26]  V. Novak,et al.  Time/frequency mapping of the heart rate, blood pressure and respiratory signals , 1993, Medical and Biological Engineering and Computing.

[27]  Amjed S. Al-Fahoum,et al.  A quantitative analysis approach for cardiac arrhythmia classification using higher order spectral techniques , 2005, IEEE Transactions on Biomedical Engineering.

[28]  C. Florkowski Sensitivity, specificity, receiver-operating characteristic (ROC) curves and likelihood ratios: communicating the performance of diagnostic tests. , 2008, The Clinical biochemist. Reviews.

[29]  A. Murray,et al.  Recognition of ventricular fibrillation using neural networks , 1994, Medical and Biological Engineering and Computing.

[30]  J. Tulen,et al.  The exponential distribution applied to nonequidistantly sampled cardiovascular time series. , 1996, Computers and biomedical research, an international journal.

[31]  Willis J. Tompkins,et al.  A Real-Time QRS Detection Algorithm , 1985, IEEE Transactions on Biomedical Engineering.

[32]  Mark D. Huffman,et al.  Heart disease and stroke statistics--2013 update: a report from the American Heart Association. , 2013, Circulation.

[33]  A. Goldberger Clinical Electrocardiography: A Simplified Approach , 1977 .

[34]  A. Malliani,et al.  Heart rate variability. Standards of measurement, physiological interpretation, and clinical use , 1996 .

[35]  P. Novak,et al.  Influence of respiration on heart rate and blood pressure fluctuations. , 1993, Journal of applied physiology.

[36]  Stéphane Mallat,et al.  A Theory for Multiresolution Signal Decomposition: The Wavelet Representation , 1989, IEEE Trans. Pattern Anal. Mach. Intell..

[37]  Dimitrios I. Fotiadis,et al.  Automatic arrhythmia detection based on time and time-frequency analysis of heart rate variability , 2004, Comput. Methods Programs Biomed..

[38]  I. P. Mitov A method for assessment and processing of biomedical signals containing trend and periodic components. , 1998, Medical engineering & physics.

[39]  Ronald Schondorf,et al.  The effect of severe brainstem injury on heart rate and blood pressure oscillations , 2005, Clinical Autonomic Research.

[40]  Ales Belsak,et al.  Adaptive Wavelet Transform Method to Identify Cracks in Gears , 2010, EURASIP J. Adv. Signal Process..

[41]  Patrick E. McSharry,et al.  A dynamical model for generating synthetic electrocardiogram signals , 2003, IEEE Transactions on Biomedical Engineering.

[42]  P. Novak,et al.  Postural tachycardia syndrome: time frequency mapping. , 1996, Journal of the autonomic nervous system.

[43]  Dong Yu,et al.  Deep Learning: Methods and Applications , 2014, Found. Trends Signal Process..

[44]  A. Flisberg,et al.  Automatic classification of background EEG activity in healthy and sick neonates , 2010, Journal of neural engineering.

[45]  Paul S Addison,et al.  Wavelet transforms and the ECG: a review , 2005, Physiological measurement.

[46]  John M. O'Toole,et al.  Time-Frequency Processing of Nonstationary Signals: Advanced TFD Design to Aid Diagnosis with Highlights from Medical Applications , 2013, IEEE Signal Processing Magazine.

[47]  Boualem Boashash,et al.  Principles of time-frequency feature extraction for change detection in non-stationary signals: Applications to newborn EEG abnormality detection , 2015, Pattern Recognit..

[48]  A. Murray,et al.  Comparison of four techniques for recognition of ventricular fibrillation from the surface ECG , 1993, Medical and Biological Engineering and Computing.

[49]  G. Breithardt,et al.  Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. , 1996 .

[50]  N.V. Thakor,et al.  Multiway sequential hypothesis testing for tachyarrhythmia discrimination , 1994, IEEE Transactions on Biomedical Engineering.

[51]  G.B. Moody,et al.  The impact of the MIT-BIH Arrhythmia Database , 2001, IEEE Engineering in Medicine and Biology Magazine.

[52]  BoashashBoualem,et al.  Time-frequency features for pattern recognition using high-resolution TFDs , 2015 .

[53]  A. Dliou,et al.  Abnormal ECG Signals Analysis Using Non-Parametric Time–Frequency Techniques , 2014 .

[54]  G. Billman Heart Rate Variability – A Historical Perspective , 2011, Front. Physio..

[55]  Boualem Boashash,et al.  Estimating the number of components of a multicomponent nonstationary signal using the short-term time-frequency Rényi entropy , 2011, EURASIP J. Adv. Signal Process..

[56]  Z. Fayad,et al.  The diagnosis and management of ventricular arrhythmias , 2011, Nature Reviews Cardiology.

[57]  Ingrid Daubechies,et al.  Ten Lectures on Wavelets , 1992 .

[58]  Rodrigo Castañeda-Miranda,et al.  DSP-based arrhythmia classification using wavelet transform and probabilistic neural network , 2017, Biomed. Signal Process. Control..

[59]  Pere Caminal,et al.  Time-Frequency Analysis of the RT and RR Variability to Stratify Hypertrophic Cardiomyopathy Patients , 2000, Comput. Biomed. Res..