Insulin prevents liver damage and preserves liver function in lipopolysaccharide-induced endotoxemic rats.

[1]  R. Einspanier,et al.  Insulin attenuates the systemic inflammatory response in endotoxemic rats. , 2004, Endocrinology.

[2]  R. Horch,et al.  Insulin Treatment Improves Hepatic Morphology and Function Through Modulation of Hepatic Signals After Severe Trauma , 2004, Annals of surgery.

[3]  H. Moshage,et al.  Defying death: the hepatocyte's survival kit. , 2004, Clinical science.

[4]  A. Słowik,et al.  Serum Albumin Level as a Predictor of Ischemic Stroke Outcome , 2004, Stroke.

[5]  Dagmar Klein,et al.  Insulin Treatment Improves the Systemic Inflammatory Reaction to Severe Trauma , 2004, Annals of surgery.

[6]  R. Einspanier,et al.  Differences in the Hepatic Signal Transcription Pathway and Cytokine Expression Between Thermal Injury and Sepsis , 2003, Shock.

[7]  G. Van den Berghe,et al.  Metabolic, endocrine, and immune effects of stress hyperglycemia in a rabbit model of prolonged critical illness. , 2003, Endocrinology.

[8]  U. Das Current advances in sepsis and septic shock with particular emphasis on the role of insulin. , 2003, Medical science monitor : international medical journal of experimental and clinical research.

[9]  G. Gores,et al.  Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis. , 2003, Gastroenterology.

[10]  H. Shapiro,et al.  Low albumin level in the emergency department: a potential independent predictor of delayed mortality in blunt trauma. , 2003, The Journal of emergency medicine.

[11]  B. Bistrian,et al.  Hyperglycemia induced by glucose infusion causes hepatic oxidative stress and systemic inflammation, but not STAT3 or MAP kinase activation in liver in rats. , 2003, Metabolism: clinical and experimental.

[12]  H. Jaeschke,et al.  Recovery of hepatocellular ATP and “pericentral apoptosis” after hemorrhage and resuscitation , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[13]  T. Möröy,et al.  Expression of ribosomal and translation-associated genes is correlated with a favorable clinical course in chronic lymphocytic leukemia. , 2003, Blood.

[14]  Steven E Wolf,et al.  Hyperglycemia exacerbates muscle protein catabolism in burn-injured patients , 2002, Critical care medicine.

[15]  R. Marfella,et al.  Inflammatory Cytokine Concentrations Are Acutely Increased by Hyperglycemia in Humans: Role of Oxidative Stress , 2002, Circulation.

[16]  R. Einspanier,et al.  Insulin Attenuates the Systemic Inflammatory Response to Thermal Trauma , 2002, Molecular medicine.

[17]  U. Das Insulin and inflammation: further evidence and discussion. , 2002, Nutrition.

[18]  A. Aljada,et al.  The anti-inflammatory and potential anti-atherogenic effect of insulin: a new paradigm , 2002, Diabetologia.

[19]  A. Aljada,et al.  Insulin inhibits the pro-inflammatory transcription factor early growth response gene-1 (Egr)-1 expression in mononuclear cells (MNC) and reduces plasma tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) concentrations. , 2002, The Journal of clinical endocrinology and metabolism.

[20]  E. Ivers,et al.  Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock , 2001 .

[21]  G. V. Berghe,et al.  Intensive insulin therapy in critically ill patients. , 2001, The New England journal of medicine.

[22]  D. Chinkes,et al.  Association of hyperglycemia with increased mortality after severe burn injury. , 2001, The Journal of trauma.

[23]  G. Clermont,et al.  Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care , 2001, Critical care medicine.

[24]  A. Aljada,et al.  Insulin Inhibits Intranuclear Nuclear Factor κB and Stimulates IκB in Mononuclear Cells in Obese Subjects: Evidence for an Anti-inflammatory Effect? , 2001 .

[25]  M. Spies,et al.  Cell proliferation, apoptosis, NF-kappaB expression, enzyme, protein, and weight changes in livers of burned rats. , 2001, American journal of physiology. Gastrointestinal and liver physiology.

[26]  E. Shohami,et al.  Changes in regional energy metabolism after closed head injury in the rat , 2001, Journal of Molecular Neuroscience.

[27]  K. Tracey,et al.  High Mobility Group 1 Protein (Hmg-1) Stimulates Proinflammatory Cytokine Synthesis in Human Monocytes , 2000, The Journal of experimental medicine.

[28]  K. Tracey,et al.  HMG-1 as a late mediator of endotoxin lethality in mice. , 1999, Science.

[29]  A. Maio,et al.  GENETIC COMPONENT IN THE INFLAMMATORY RESPONSE INDUCED BY BACTERIAL LIPOPOLYSACCHARIDE , 1998, Shock.

[30]  G. Salvesen,et al.  Caspases: Intracellular Signaling by Proteolysis , 1997, Cell.

[31]  G. Ramadori,et al.  Cytokines and the hepatic acute phase response , 1997, The Journal of pathology.

[32]  Dean P. Jones,et al.  Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked , 1997, Science.

[33]  H. Reber,et al.  Cytokines and acute pancreatitis. , 1996, Gastroenterology.

[34]  H. Steller Mechanisms and genes of cellular suicide , 1995, Science.

[35]  C. Dinarello,et al.  The interleuldn-1 family: 10 years of discovery’ , 2004 .

[36]  C G Figdor,et al.  Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes , 1991, The Journal of experimental medicine.

[37]  Kevin J. Tracey,et al.  Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia , 1987, Nature.

[38]  D. Williamson,et al.  Time course of changes in hepatic metabolism in response to sepsis in the rat: impairment of gluconeogenesis and ketogenesis in vitro. , 1987, Clinical science.

[39]  P. Chomczyński,et al.  Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. , 1987, Analytical biochemistry.

[40]  J. D. Albert,et al.  Shock and tissue injury induced by recombinant human cachectin. , 1986, Science.

[41]  Greet Van den Berghe,et al.  Insulin therapy for the critically ill patient. , 2003 .

[42]  A. Aljada,et al.  Insulin as an anti-inflammatory and antiatherosclerotic hormone. , 2003, Clinical cornerstone.

[43]  A. Aljada Insulin Inhibits NF B and MCP-1 Expression in Human Aortic Endothelial Cells , 2001 .

[44]  A. Aljada,et al.  Insulin Inhibits NFκB and MCP-1 Expression in Human Aortic Endothelial Cells , 2001 .

[45]  R. Andersson,et al.  The influence of apoptosis on intestinal barrier integrity in rats. , 1998, Scandinavian journal of gastroenterology.

[46]  E. Deitch,et al.  Sepsis and multiple organ dysfunction syndrome: a clinical-mechanistic overview. , 1995, New horizons.

[47]  F. Townsend New horizons , 1943 .