Discovery and optimization of new benzimidazole- and benzoxazole-pyrimidone selective PI3Kβ inhibitors for the treatment of phosphatase and TENsin homologue (PTEN)-deficient cancers.
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J. Nicolas | C. Lengauer | L. Vincent | A. Karlsson | A. Rak | T. Bertrand | N. Michot | J. Marquette | P. Lejeune | V. Certal | Y. El-Ahmad | Hélène Bonnevaux | A. Virone-Oddos | F. Halley | Fabienne Thompson | J. Carry | C. Delorme | P. Abecassis | F. Chatreaux | L. Schio | P. Below | Fabienne Pilorge | Bruno Filoche-Rommé | Odile Angouillant-Boniface | T. Bénard | Isabelle Vade | Gilles Lebourg | Audrey Louboutin | Laurent Schio | Jean-Christophe Carry